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Fig. 7. Anti-HMGB1 antibody treatment decreases hemorrhage-induced activation of NF-B in the lungs. One hour after the induction of hemorrhage, mice were injected with either control chicken IgY (Hem+Cont Ab, 200 µg/mice) or polyclonal chicken IgY anti-HMGB1 antibody (Hem+Anti-HMGB1, 200 µg/mice). Four hours after the induction of hemorrhage, mice were killed and NF-B activity was determined in the lung with EMSA. WT and MT represent oligonucleotides of wild-type and mutant NF-B (Santa Cruz Biotechnology, Santa Cruz, CA) sequences, respectively. The data shown are representative of 3 independent experiments. Shown is the relationship of each group to control, using the combined results from 3 independent experiments. *P < 0.05 compared with control; P < 0.05 compared with Hem+Cont Ab.