AJP - Lung AJP: Lung Cellular and Molecular Physiology
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Am J Physiol Lung Cell Mol Physiol 257: L190-L194, 1989;
1040-0605/89 $5.00
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AJP - Lung Cellular and Molecular Physiology, Vol 257, Issue 4 190-L194, Copyright © 1989 by American Physiological Society

ARTICLES

Phospholipid transfer proteins in mammalian lung

R. H. Lumb
Department of Biology, Western Carolina University, Cullowhee, North Carolina 28723.

Proteins that catalyze the transfer of phospholipids between membranes are known to occur in the mammalian lung and may play roles in the pulmonary surfactant system. These roles may include 1) packaging of newly synthesized as well as recycled surfactant phospholipid into lamellar bodies, the intracellular storage form of surfactant phospholipid, 2) extracellular movement of phospholipid between the compartments in the alveolar subphase, and 3) delivery of phospholipid to membrane sites during signal transduction events. The nature and distribution of these proteins are discussed as they relate to the pulmonary surfactant system.




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