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Am J Physiol Lung Cell Mol Physiol 257: L331-L337, 1989;
1040-0605/89 $5.00
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AJP - Lung Cellular and Molecular Physiology, Vol 257, Issue 6 331-L337, Copyright © 1989 by American Physiological Society

ARTICLES

Receptors for extracellular matrix components

J. A. McDonald
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.

The extracellular matrix determines the shape and function of multicellular organisms and permits orderly repair after injury. Although the inherent self-assembly properties of many extracellular matrix components such as collagen and elastin foster their deposition and supramolecular organization, cells ultimately dictate the location and composition of regional matrices. These matrices in turn communicate with cells and regulate their attachment, movement, growth, and gene expression. This complex interaction between cells and their matrix is mediated via specific cellular receptors for matrix components, including peripheral and integral membrane glycoproteins, proteoglycans, and glycosyltransferases. This commentary reviews recent advances in the structure and function of receptors for extracellular matrix components.




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