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Am J Physiol Lung Cell Mol Physiol 272: L639-L643, 1997;
1040-0605/97 $5.00
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AJP - Lung Cellular and Molecular Physiology, Vol 272, Issue 4 639-L643, Copyright © 1997 by American Physiological Society

ARTICLES

Contribution of PKC to beta-hexosaminidase-induced airway smooth muscle proliferation

D. B. Lew, E. R. Brown, B. K. Dempsey, H. M. Wright and K. U. Malik
Department of Pediatrics, College of Medicine, University of Tennessee, Memphis 38103, USA.

beta-Hexosaminidases (Hex) A and B promote mitogenesis via airway smooth muscle (ASM) mannose receptor. The objective of this study was to elucidate the contribution of protein kinase C (PKC) in Hex-induced mitogenesis in ASM cells (ASMC). Exposure of ASMC to Hex caused increases in both the calcium-dependent and the calcium-independent PKC activities. Both downregulation of PKC and PKC inhibitors staurosporine and calphostin C diminished Hex-induced DNA synthesis and cell number. Hex-induced DNA synthesis was enhanced by a diacylglycerol kinase inhibitor, R-59022, which was blocked by calphostin C. These data suggest that activation of PKC in part mediates Hex-induced mitogenesis in ASMC.


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