AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 272: L1059-L1065, 1997;
1040-0605/97 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ijsselstijn, H.
Right arrow Articles by Tibboel, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ijsselstijn, H.
Right arrow Articles by Tibboel, D.

AJP - Lung Cellular and Molecular Physiology, Vol 272, Issue 6 1059-L1065, Copyright © 1997 by American Physiological Society

ARTICLES

Prenatal hormones alter antioxidant enzymes and lung histology in rats with congenital diaphragmatic hernia

H. Ijsselstijn, B. A. Pacheco, A. Albert, W. Sluiter, P. K. Donahoe, J. C. De Jongste, J. J. Schnitzer and D. Tibboel
Department of Pediatric Surgery, Erasmus University Rotterdam, The Netherlands.

Prenatal administration of dexamethasone (Dex) and thyrotropin-releasing hormone (TRH) synergistically enhances lung maturity, but TRH suppresses the antioxidant enzyme activity. Prenatal hormonal therapy improves alveolar surfactant content and lung compliance in rats with congenital diaphragmatic hernia (CDH). In full term neonatal rats with CDH we studied the effects of prenatal Dex or Dex+TRH on antioxidant enzyme activity at birth, on survival, and on lung morphometry after 4 h of ventilation with 100% O2. CDH was induced by administration of 2,4-dichlorophenyl-p-nitro-phenylether (Nitrofen) on gestational day 10. Dex+TRH-treated CDH rats had lower activity of glutathione reductase after birth than did sham-treated CDH pups. Dex-treated and sham-treated pups had similar antioxidant enzyme activity. Hormonal treatment did not change survival during ventilation. The average airspace volume increased in Dex-treated CDH pups after ventilation, with a small synergistic effect after addition of TRH. On the basis of our findings, we speculate that prenatal administration of Dex is the best choice to improve lung maturity and airspace volume in CDH patients.


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
R. Keijzer, J. Liu, J. Deimling, D. Tibboel, and M. Post
Dual-Hit Hypothesis Explains Pulmonary Hypoplasia in the Nitrofen Model of Congenital Diaphragmatic Hernia
Am. J. Pathol., April 1, 2000; 156(4): 1299 - 1306.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Kitano, P. Davies, D. von Allmen, N. S. Adzick, and A. W. Flake
Fetal tracheal occlusion in the rat model of nitrofen-induced congenital diaphragmatic hernia
J Appl Physiol, August 1, 1999; 87(2): 769 - 775.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. Thebaud, D. Tibboel, C. Rambaud, J.-C. Mercier, J. R. Bourbon, A. T. Dinh-Xuan, and S. L. Archer
Vitamin A decreases the incidence and severity of nitrofen-induced congenital diaphragmatic hernia in rats
Am J Physiol Lung Cell Mol Physiol, August 1, 1999; 277(2): L423 - L429.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online