AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 273: L104-L112, 1997;
1040-0605/97 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Delclaux, C.
Right arrow Articles by Harf, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Delclaux, C.
Right arrow Articles by Harf, A.

AJP - Lung Cellular and Molecular Physiology, Vol 273, Issue 1 104-L112, Copyright © 1997 by American Physiological Society

ARTICLES

Alveolar neutrophils in endotoxin-induced and bacteria-induced acute lung injury in rats

C. Delclaux, S. Rezaiguia-Delclaux, C. Delacourt, C. Brun-Buisson, C. Lafuma and A. Harf
Institut National de la Sante et de la Recherche Medicale, Unite 296, Hopital Henri Mondor, Creteil, France.

Polymorphonuclear neutrophils (PMNs) are thought to play a major role in the pathogenesis of adult respiratory distress syndrome. Because the alveolar epithelium is a decisive factor in alveolo-capillary wall permeability, a toxic effect of emigrated PMNs in alveolar spaces is conceivable. We evaluated alveolar PMN function in two rat models of acute lung injury induced by alveolar instillation of endotoxin [lipopolysaccharide (LPS)] or live Pseudomonas aeruginosa (PYO). Alveolar PMNs were isolated from bronchoalveolar lavage fluid 4 and 24 h after the challenge. Hypoxemia was assessed based on the ratio arterial partial pressure of O2 (PaO2)/fraction of inspired O2 (FIO2) during mechanical ventilation. The severity of lung injury in the two models was clearly different, since PaO2/FIO2 were approximately 400 mmHg in PYO- and LPS-induced injuries, respectively. Both contrast, alveolar neutrophil influx, unstimulated oxygen metabolite production, and proteinase (elastase, gelatinase B) secretions of ex vivo alveolar PMNs were not larger in the PYO model. Thus the difference in severity was not associated with variations in alveolar neutrophil recruitment or activation. Moreover, gelatinase and leukocyte elastase activities were absent in bronchoalveolar fluid, indicating effective antiproteinase defense in alveolar spaces. We conclude that alveolar neutrophils are not sufficient to create severe respiratory failure.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. L. Martin, T. A. Sheikh, K. J. Leco, J. F. Lewis, and R. A. W. Veldhuizen
Contribution of alveolar macrophages to the response of the TIMP-3 null lung during a septic insult
Am J Physiol Lung Cell Mol Physiol, September 1, 2007; 293(3): L779 - L789.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. G. Davidson, A. D. Bersten, H. A. Barr, K. D. Dowling, T. E. Nicholas, and I. R. Doyle
Endotoxin Induces Respiratory Failure and Increases Surfactant Turnover and Respiration Independent of Alveolocapillary Injury in Rats
Am. J. Respir. Crit. Care Med., June 1, 2002; 165(11): 1516 - 1525.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Corbel, N. Germain, J. Lanchou, S. Molet, P. M. R. e Silva, M. A. Martins, E. Boichot, and V. Lagente
The Selective Phosphodiesterase 4 Inhibitor RP 73-401 Reduced Matrix Metalloproteinase 9 Activity and Transforming Growth Factor-beta Release During Acute Lung Injury in Mice: The Role of the Balance Between Tumor Necrosis Factor-alpha and Interleukin-10
J. Pharmacol. Exp. Ther., April 1, 2002; 301(1): 258 - 265.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M.-L. Franco, P. Waszak, G. Banalec, M. Levame, C. Lafuma, A. Harf, and C. Delacourt
Pre- and Postnatal Lung Development, Maturation, and Plasticity: LPS-induced lung injury in neonatal rats: changes in gelatinase activities and consequences on lung growth
Am J Physiol Lung Cell Mol Physiol, March 1, 2002; 282(3): L491 - L500.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
E. Azoulay, H. Attalah, A. Harf, B. Schlemmer, and C. Delclaux
Granulocyte Colony-Stimulating Factor or Neutrophil-Induced Pulmonary Toxicity: Myth or Reality? : Systematic Review of Clinical Case Reports and Experimental Data
Chest, November 1, 2001; 120(5): 1695 - 1701.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. YAMADA, H. MIYAZAKI, T. KIKUCHI, J. FUJIMOTO, and I. KUDOH
Acid Instillation Enhances the Inflammatory Response to Subsequent Lipopolysaccharide Challenge in Rats
Am. J. Respir. Crit. Care Med., October 1, 2000; 162(4): 1366 - 1371.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. JEAN, S. REZAIGUIA-DELCLAUX, C. DELACOURT, R. LECLERCQ, C. LAFUMA, C. BRUN-BUISSON, A. HARF, and C. DELCLAUX
Protective Effect of Endotoxin Instillation on Subsequent Bacteria-induced Acute Lung Injury in Rats
Am. J. Respir. Crit. Care Med., December 1, 1998; 158(6): 1702 - 1708.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. Hierholzer, J. C. Kalff, L. Omert, K. Tsukada, J. E. Loeffert, S. C. Watkins, T. R. Billiar, and D. J. Tweardy
Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury
Am J Physiol Lung Cell Mol Physiol, September 1, 1998; 275(3): L611 - L621.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online