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Am J Physiol Lung Cell Mol Physiol 274: L226-L234, 1998;
1040-0605/98 $5.00
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Vol. 274, Issue 2, L226-L234, February 1998

Differences between rat alveolar and interstitial macrophages 5 wk after quartz exposure

Göran Zetterberg1, Anne Johansson2,3, Joachim Lundahl4, Margot Lundborg2, Carl Magnus Sköld1, Göran Tornling1, Per Camner2, and Anders Eklund1

1 Division of Respiratory Medicine, Department of Medicine, and 4 Department of Clinical Immunology, Karolinska Hospital, S-171 76 Stockholm; 2 Division of Inhalation Toxicology, Institute of Environmental Medicine, Karolinska Institute, S-171 77 Stockholm; and 3 The Wenner-Gren Institute, University of Stockholm, S-106 91 Stockholm, Sweden

Macrophages play an essential role in pulmonary host defense. We investigated differences between rat alveolar (AM) and interstitial (IM) macrophages after exposure in vivo to quartz, an inducer of intensive alveolitis. Rats were exposed to 0.5 ml of saline without (n = 8) or with (n = 8) 10 mg of quartz by intratracheal instillation. In a third group (n = 8), 10 mg of surfactant were added to the quartz mixture. Five weeks later, AM were recovered by bronchoalveolar lavage and IM by mechanical fragmentation of the lung, followed by enzymatic treatment. Contamination of AM to the IM fraction was calculated to be 12-15%. After quartz exposure, the expression of major histocompatibility complex class Ia was increased in both AM and IM fractions. The receptor corresponding to human complement receptor 3 increased in AM after quartz exposure, and AM from quartz-exposed animals had a lower metabolic activation. Our findings indicate that IM are immunocompetent cells and that differences between AM and IM fractions occur upon quartz-induced inflammation. This response is not affected by addition of surfactant.

adhesion; bronchoalveolar lavage; metabolic activation; phagocytosis; receptor expression


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