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Am J Physiol Lung Cell Mol Physiol 274: L235-L243, 1998;
1040-0605/98 $5.00
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Vol. 274, Issue 2, L235-L243, February 1998

Alveolar liquid clearance in the anesthetized ventilated guinea pig

Andreas Norlin, Neelu Finley, Parisa Abedinpour, and Hans G. Folkesson

Department of Animal Physiology, Lund University, S-223 62 Lund, Sweden

Alveolar liquid clearance was examined in ventilated, anesthetized guinea pigs. An isosmolar 5% albumin solution was instilled into the lungs. Alveolar liquid clearance was studied over 1 h and was measured from the increase in alveolar protein concentration as water was reabsorbed. Basal alveolar liquid clearance was 38% of instilled volume. The high basal alveolar liquid clearance was not secondary to endogenous catecholamine release. Compared with control animals, epinephrine and the general beta -adrenergic agonist isoproterenol increased alveolar liquid clearance to ~50% of instilled volume (P < 0.05), whereas the beta 2-adrenergic agonist terbutaline was without effect. The stimulation of alveolar liquid clearance by epinephrine or isoproterenol was completely inhibited by the addition of the general beta -adrenergic inhibitor propranolol or the beta 1-adrenergic inhibitor atenolol. Alveolar liquid clearance was inhibited by the sodium-channel inhibitor amiloride by 30-40% in control animals and in animals treated with epinephrine or isoproterenol. Isoproterenol and epinephrine, but not terbutaline, increased adenosine 3',5'-cyclic monophosphate in in vitro incubated lung tissue. The results suggest that alveolar liquid clearance in guinea pigs is mediated partly through amiloride-sensitive sodium channels and that alveolar liquid clearance can be increased by stimulation of primarily beta 1-adrenergic receptors.

amiloride; beta -adrenergic stimulation; adenosine 3',5'-cyclic monophosphate generation; epinephrine; lung


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