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Am J Physiol Lung Cell Mol Physiol 274: L264-L269, 1998;
1040-0605/98 $5.00
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Vol. 274, Issue 2, L264-L269, February 1998

Unaltered pulmonary capillary surface area in the presence of changing arterial resistance

Lyle E. Fisher Jr.1, Attila Cziraki2, Curt M. Steinhart1, and John D. Catravas2

1 Section of Pediatric Critical Care Medicine, Department of Pediatrics, and 2 Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912

We hypothesized that capillary recruitment may not be solely dependent on extracapillary factors. To test this hypothesis, rabbits were anesthetized and placed on total cardiac bypass at a constant, physiological pulmonary blood flow. Vascular occlusion techniques were combined with measurement of the transpulmonary metabolism of an angiotensin-converting enzyme substrate, allowing the concomitant assessment of changes in segmental resistances and dynamically perfused capillary surface area. Intra-arterial serotonin infusion increased upstream pulmonary vascular resistances without affecting dynamically perfused capillary surface area. Intra-arterial isoproterenol infusion diminished serotonin-induced increased upstream resistances, also without affecting capillary surface area. These findings support the hypothesis that pulmonary capillary recruitment may not be solely dependent on extracapillary factors.

isoproterenol; serotonin; capillary recruitment; pulmonary circulation; pulmonary hypertension; rabbit


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