AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 274: L301-L304, 1998;
1040-0605/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lien, Y.-H. H.
Right arrow Articles by Lai, L.-W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lien, Y.-H. H.
Right arrow Articles by Lai, L.-W.
Vol. 274, Issue 2, L301-L304, February 1998

RAPID COMMUNICATION
Respiratory acidosis in carbonic anhydrase II-deficient mice

Yeong-Hau H. Lien and Li-Wen Lai

Department of Medicine, University of Arizona Health Sciences Center, Tucson, Arizona 85724

To investigate the role of carbonic anhydrase (CA) II on pulmonary CO2 exchange, we analyzed arterial blood gases from CA II-deficient and normal control mice. CA II-deficient mice had a low arterial blood pH (7.18 ± 0.06) and HCO<SUP>−</SUP><SUB>3</SUB> concentration ([HCO<SUP>−</SUP><SUB>3</SUB>]; 17.5 ± 1.9 meq/l) and a high PCO2 (47.4 ± 5.3 mmHg), consistent with mixed respiratory and metabolic acidosis. To eliminate the influence of metabolic acidosis on arterial blood gases, NaHCO3 (4 mmol/kg body weight) was given intraperitoneally, and arterial blood gases were analyzed 4 h later. Normal mice had a small increase in pH and were able to maintain PCO2 and [HCO<SUP>−</SUP><SUB>3</SUB>]. The metabolic acidosis in CA II-deficient mice was corrected ([HCO<SUP>−</SUP><SUB>3</SUB>], 22.9 ± 2.4 meq/l), and respiratory acidosis became more profound (PCO2, 50.4 ± 2.4 mmHg). These results indicate that CA II-deficient mice have a partial respiratory compensation for metabolic acidosis. We conclude that CA II-deficient mice have a mixed respiratory and metabolic acidosis. It is most likely that CO2 retention in these animals is due to CA II deficiency in both red blood cells and type II pneumocytes.

carbon dioxide exchange; arterial blood gas; metabolic acidosis; lung


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
P. Wetzel, R. J. Scheibe, B. Hellmann, J. Hallerdei, G. N. Shah, A. Waheed, G. Gros, and W. S. Sly
Carbonic anhydrase XIV in skeletal muscle: subcellular localization and function from wild-type and knockout mice
Am J Physiol Cell Physiol, July 1, 2007; 293(1): C358 - C366.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
T. E. Decoursey
Voltage-Gated Proton Channels and Other Proton Transfer Pathways
Physiol Rev, April 1, 2003; 83(2): 475 - 579.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. Dauger, L. Ferkdadji, G. Saumon, G. Vardon, M. Peuchmaur, C. Gaultier, and J. Gallego
Neonatal Exposure to 65% Oxygen Durably Impairs Lung Architecture and Breathing Pattern in Adult Mice
Chest, February 1, 2003; 123(2): 530 - 538.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. E. DeCoursey
Hypothesis: do voltage-gated H+ channels in alveolar epithelial cells contribute to CO2 elimination by the lung?
Am J Physiol Cell Physiol, January 1, 2000; 278(1): C1 - C10.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Q. Zhou, L. Clarke, R. Nie, K. Carnes, L.-W. Lai, Y.-H. H. Lien, A. Verkman, D. Lubahn, J. S. Fisher, B. S. Katzenellenbogen, et al.
From the Cover: Estrogen action and male fertility: Roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function
PNAS, November 20, 2001; 98(24): 14132 - 14137.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online