AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 274: L313-L319, 1998;
1040-0605/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Clerch, L. B.
Right arrow Articles by Berkovich, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Clerch, L. B.
Right arrow Articles by Berkovich, A.
Vol. 274, Issue 3, L313-L319, March 1998

Molecular mechanisms of antioxidant enzyme expression in lung during exposure to and recovery from hyperoxia

Linda Biadasz Clerch1,2, Donald Massaro1,3, and Alla Berkovich1,2

1 Lung Biology Laboratory, and Departments of 2 Pediatrics and 3 Medicine, Georgetown University School of Medicine, Washington, DC 20007-2197

Manganese superoxide dismutase (MnSOD) activity falls ~50% in lung during 48 h of exposure of adult rats to >95% O2 (L. B. Clerch and D. Massaro. J. Clin. Invest. 91: 499-508, 1993). We now show that hyperoxia also decreased MnSOD activity in lungs of adult baboons, making the phenomenon potentially more important to humans. In rats, a decrease in lung MnSOD activity during an initial 48 h of exposure to >95% O2 and its increase during an immediately subsequent 24 h in air were due to decreases and increases, respectively, in MnSOD specific activity and synthesis rate; the latter was due to altered translational efficiency. The concentration in the lung of copper-zinc superoxide dismutase mRNA, catalase mRNA, and glutathione peroxidase mRNA, unchanged during the initial 48 h of exposure to O2, rose approximately twofold during reexposure to O2 after 24 h in air. The demonstration that the fall in MnSOD activity is translationally and posttranslationally regulated during the initial exposure to hyperoxia suggests that gene transfer to increase MnSOD activity in hyperoxic lungs may also require therapy that maintains translational efficiency and MnSOD specific activity.

translational efficiency; manganese superoxide dismutase; catalase; copper-zinc superoxide dismutase; glutathione peroxidase; gene expression; baboons; rats


This article has been cited by other articles:


Home page
 J. Histochem. Cytochem.Home page
R. Kaarteenaho-Wiik and V. L. Kinnula
Distribution of Antioxidant Enzymes in Developing Human Lung, Respiratory Distress Syndrome, and Bronchopulmonary Dysplasia
J. Histochem. Cytochem., September 1, 2004; 52(9): 1231 - 1240.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H.-S. Kim, Y. Manevich, S. I. Feinstein, J. H. Pak, Y. S. Ho, and A. B. Fisher
Induction of 1-cys peroxiredoxin expression by oxidative stress in lung epithelial cells
Am J Physiol Lung Cell Mol Physiol, August 1, 2003; 285(2): L363 - L369.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. Dirami, D. Massaro, and L. B. Clerch
Regulation of lung manganese superoxide dismutase: species variation in response to lipopolysaccharide
Am J Physiol Lung Cell Mol Physiol, May 1, 1999; 276(5): L705 - L708.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. L. Morton, K. C. Das, X.-L. Guo, D. N. Ikle, and C. W. White
Effect of oxygen on lung superoxide dismutase activities in premature baboons with bronchopulmonary dysplasia
Am J Physiol Lung Cell Mol Physiol, January 1, 1999; 276(1): L64 - L74.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online