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Am J Physiol Lung Cell Mol Physiol 274: L351-L359, 1998;
1040-0605/98 $5.00
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Vol. 274, Issue 3, L351-L359, March 1998

A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium

Glenn J. Pelletier1, Steven L. Brody2, Helen Liapis3, Robert A. White4, and Brian P. Hackett5

Departments of 1 Surgery, 2 Internal Medicine, 3 Pathology, and 5 Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110; and 4 Section of Genetics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri 64108

Members of the forkhead/winged-helix transcription factor family play crucial roles during vertebrate development. A human hepatocyte nuclear factor/forkhead homolog (HFH)-4 cDNA encoding a 421-amino acid protein was isolated from a human fetal lung cDNA library. By Southern blot analysis of human-rodent somatic cell hybrid genomic DNA, the human HFH-4 gene localizes to chromosome 17q23-qter. This is the locus of another forkhead/winged-helix gene, the interleukin enhancer binding factor gene. RNA blot analysis revealed a 2.5-kilobase human HFH-4 transcript in fetal lung, kidney, and brain as well as in adult reproductive tissues, lung, and brain. By in situ hybridization, HFH-4 expression is associated with differentiation of the proximal pulmonary epithelium, starting during the pseudoglandular stage of human lung development. During human renal morphogenesis, HFH-4 is expressed in the developing epithelial cells of the ureteric duct, glomerulus, and epithelial vesicles. The unique pattern of HFH-4 expression during human fetal development suggests a role for this forkhead/winged-helix factor during pulmonary and renal epithelial development.

transcription factors; human development; gene expression


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