AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 275: L365-L371, 1998;
1040-0605/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lasky, J. A.
Right arrow Articles by Friedman, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lasky, J. A.
Right arrow Articles by Friedman, M.
Vol. 275, Issue 2, L365-L371, August 1998

Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis

Joseph A. Lasky1,3, Luis A. Ortiz1,3, Boihoang Tonthat1,3, Gary W. Hoyle1,3, Miriam Corti2,3, Grace Athas2,3, Giuseppe Lungarella4, Arnold Brody2,3, and Mitchell Friedman1,3

1 Section of Pulmonary Diseases, Critical Care, and Environmental Medicine, Department of Medicine; 2 Department of Pathology and Environmental Health Sciences; and 3 Tulane/Xavier Center for Bioenvironmental Research, Tulane University Medical Center, New Orleans, Louisiana 70112; and 4 Departament di Patologia Generale, Universita di Siena, Siena, Italy 53100

Connective tissue growth factor (CTGF) is a newly described 38-kDa peptide mitogen for fibroblasts and a promoter of connective tissue deposition in the skin. The CTGF gene promotor contains a transforming growth factor-beta 1 (TGF-beta 1) response element. Because TGF-beta 1 expression is upregulated in several models of fibroproliferative lung disease, we asked whether CTGF is also upregulated in a murine lung fibrosis model and whether CTGF could mediate some of the fibrogenic effects associated with TGF-beta 1. A portion of the rat CTGF gene was cloned and used to show that primary isolates of both murine and human lung fibroblasts express CTGF mRNA in vitro. There was a greater than twofold increase in CTGF expression in both human and murine lung fibroblasts 2, 4, and 24 h after the addition of TGF-beta 1 in vitro. A bleomycin-sensitive mouse strain (C57BL/6) and a bleomycin-resistant mouse strain (BALB/c) were given bleomycin, a known lung fibrogenic agent. CTGF mRNA expression was upregulated in the sensitive, but not in the resistant, mouse strain after administration of bleomycin. In vivo differences in the CTGF expression between the two mouse strains were not due to an inherent inability of BALB/c lung fibroblasts to respond to TGF-beta 1 because fibroblasts from untreated BALB/c mouse lung upregulated their CTGF message when treated with TGF-beta 1 in vitro. These data demonstrate that CTGF is expressed in lung fibroblasts and may play a role in the pathogenesis of lung fibrosis.

transforming growth factor-beta 1; collagen; mice


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. L. Fattman, F. Gambelli, G. Hoyle, B. R. Pitt, and L. A. Ortiz
Epithelial expression of TIMP-1 does not alter sensitivity to bleomycin-induced lung injury in C57BL/6 mice
Am J Physiol Lung Cell Mol Physiol, March 1, 2008; 294(3): L572 - L581.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. C. Wesselkamper, S. A. McDowell, M. Medvedovic, T. P. Dalton, H. S. Deshmukh, M. A. Sartor, L. M. Case, L. N. Henning, M. T. Borchers, C. R. Tomlinson, et al.
The Role of Metallothionein in the Pathogenesis of Acute Lung Injury
Am. J. Respir. Cell Mol. Biol., January 1, 2006; 34(1): 73 - 82.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. Cavarra, F. Carraro, S. Fineschi, A. Naldini, B. Bartalesi, A. Pucci, and G. Lungarella
Early response to bleomycin is characterized by different cytokine and cytokine receptor profiles in lungs
Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1186 - L1192.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. L. Watts and M. A. Spiteri
Connective tissue growth factor expression and induction by transforming growth factor-{beta} is abrogated by simvastatin via a Rho signaling mechanism
Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1323 - L1332.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. Ogawa, W. M. Elliott, F. Hughes, T. J. Eichholtz, J. C. Hogg, and S. Hayashi
Latent adenoviral infection induces production of growth factors relevant to airway remodeling in COPD
Am J Physiol Lung Cell Mol Physiol, January 1, 2004; 286(1): L189 - L197.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. Chaqour, C. Whitbeck, J.-S. Han, E. Macarak, P. Horan, P. Chichester, and R. Levin
Cyr61 and CTGF are molecular markers of bladder wall remodeling after outlet obstruction
Am J Physiol Endocrinol Metab, October 1, 2002; 283(4): E765 - E774.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H. Matsuoka, T. Arai, M. Mori, S. Goya, H. Kida, H. Morishita, H. Fujiwara, I. Tachibana, T. Osaki, and S. Hayashi
A p38 MAPK inhibitor, FR-167653, ameliorates murine bleomycin-induced pulmonary fibrosis
Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L103 - L112.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
H. Yokoi, M. Mukoyama, A. Sugawara, K. Mori, T. Nagae, H. Makino, T. Suganami, K. Yahata, Y. Fujinaga, I. Tanaka, et al.
Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis
Am J Physiol Renal Physiol, May 1, 2002; 282(5): F933 - F942.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. KOLB, P. J. MARGETTS, T. GALT, P. J. SIME, Z. XING, M. SCHMIDT, and J. GAULDIE
Transient Transgene Expression of Decorin in the Lung Reduces the Fibrotic Response to Bleomycin
Am. J. Respir. Crit. Care Med., March 1, 2001; 163(3): 770 - 777.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. T. Allen, R. A. Knight, C. A. Bloor, and M. A. Spiteri
Enhanced Insulin-Like Growth Factor Binding Protein-Related Protein 2 (Connective Tissue Growth Factor) Expression in Patients with Idiopathic Pulmonary Fibrosis and Pulmonary Sarcoidosis
Am. J. Respir. Cell Mol. Biol., December 1, 1999; 21(6): 693 - 700.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. A. Ricupero, D. C. Rishikof, P.-P. Kuang, C. F. Poliks, and R. H. Goldstein
Regulation of connective tissue growth factor expression by prostaglandin E2
Am J Physiol Lung Cell Mol Physiol, December 1, 1999; 277(6): L1165 - L1171.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
M. R. DUNCAN, K. S. FRAZIER, S. ABRAMSON, S. WILLIAMS, H. KLAPPER, X. HUANG, and G. R. GROTENDORST
Connective tissue growth factor mediates transforming growth factor {beta}-induced collagen synthesis: down-regulation by cAMP
FASEB J, October 1, 1999; 13(13): 1774 - 1786.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online