AJP - Lung Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 275: L1069-L1077, 1998;
1040-0605/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ozaki, M.
Right arrow Articles by Marshall, B. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ozaki, M.
Right arrow Articles by Marshall, B. E.
Vol. 275, Issue 6, L1069-L1077, December 1998

Role of wall tension in hypoxic responses of isolated rat pulmonary arteries

Masami Ozaki1, Carol Marshall2, Yoshikiyo Amaki1, and Bryan E. Marshall2

2 Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania 19104; and 1 Department of Anesthesia, Jikei University School of Medicine, Tokyo 105-8461, Japan

The changes in force developed during 40-min exposures to hypoxia (37 ± 1 mmHg) were recorded in large (0.84 ± 0.02-mm-diameter) and small (0.39 ± 0.01-mm-diameter) intrapulmonary arteries during combinations of mechanical wall stretch tensions (passive + active myogenic components), equivalent to transmural vascular pressures of 5, 15, 30, 50, and 100 mmHg, and active (vasoconstriction) tensions, stimulated by PGF2alpha in doses of 0, 25, 50, and 75% effective concentrations. Constriction was observed in all arteries during the first minute; however, at any active tension, the pattern of the subsequent response was a function of the stretch tension. At 5, 15, and 30 mmHg, the constriction decreased slightly at 5 min and then increased again to remain constrictor throughout. At 50 and 100 mmHg, the initial constriction was followed by persistent dilation. Hypoxic constrictor responses, most resembling those observed in lungs in vivo and in vitro, were observed when the mechanical stretch wall tension was equivalent to 15 or 30 mmHg and the dose of PGF2alpha was 25 or 50% effective concentration. These observations reconcile many apparently contradictory results reported previously.

hypoxic pulmonary vasoconstriction; wall stress; prostaglandin F2alpha ; mechanical stretch; myogenic tone


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. Weigand, J. Foxson, J. Wang, L. A. Shimoda, and J. T. Sylvester
Inhibition of hypoxic pulmonary vasoconstriction by antagonists of store-operated Ca2+ and nonselective cation channels
Am J Physiol Lung Cell Mol Physiol, July 1, 2005; 289(1): L5 - L13.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. Weissmann, F. Grimminger, A. Olschewski, and W. Seeger
Hypoxic pulmonary vasoconstriction: a multifactorial response?
Am J Physiol Lung Cell Mol Physiol, August 1, 2001; 281(2): L314 - L317.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Dipp, P. C. G. Nye, and A. M. Evans
Hypoxic release of calcium from the sarcoplasmic reticulum of pulmonary artery smooth muscle
Am J Physiol Lung Cell Mol Physiol, August 1, 2001; 281(2): L318 - L325.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. R. Olson, M. J. Russell, and M. E. Forster
Hypoxic vasoconstriction of cyclostome systemic vessels: the antecedent of hypoxic pulmonary vasoconstriction?
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2001; 280(1): R198 - R206.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
V. Hampl and J. Herget
Role of Nitric Oxide in the Pathogenesis of Chronic Pulmonary Hypertension
Physiol Rev, October 1, 2000; 80(4): 1337 - 1372.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online