AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 276: L697-L704, 1999;
1040-0605/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Warburton, D.
Right arrow Articles by Bernfield, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Warburton, D.
Right arrow Articles by Bernfield, M.
Vol. 276, Issue 5, L697-L704, May 1999

INVITED REVIEW
Molecular embryology of the lung: then, now, and in the future

David Warburton1,2, Jingsong Zhao2, Mary Anne Berberich3, and Merton Bernfield4

1 Developmental Biology Program and Department of Surgery, Childrens Hospital Los Angeles Research Institute, and 2 Center for Craniofacial Molecular Biology, University of Southern California Schools of Medicine and Dentistry, Los Angeles, California 90027; 3 Developmental Biology and Pediatrics Group, Division of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892; and 4 Division of Developmental and Newborn Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115

Complementary molecular and genetic approaches are yielding information about gain- versus loss-of-function phenotypes of specific genes and gene families in the embryonic, fetal, neonatal, and adult lungs. New insights are being derived from the conservation of function between genes regulating branching morphogenesis of the respiratory organs in Drosophila and in the mammalian lung. The function of specific morphogenetic genes in the lung are now placed in context with pattern-forming functions in other, better understood morphogenetic fields such as the limb bud. Initiation of lung morphogenesis from the floor of the primitive foregut requires coordinated transcriptional activation and repression involving hepatocyte nuclear factor-3beta , Sonic hedgehog, patched, Gli2, and Gli3 as well as Nkx2.1. Subsequent inductive events require epithelial-mesenchymal interaction mediated by specific fibroblast growth factor ligand-receptor signaling as well as modulation by other peptide growth factors including epidermal growth factor, platelet-derived growth factor-A and transforming growth factor-beta and by extracellular matrix components. A scientific rationale for developing new therapeutic approaches to urgent questions of human pulmonary health such as bronchopulmonary dysplasia is beginning to emerge from work in this field.

sprouty; branchless; breathless; vascular endothelial growth factor; hepatocyte forkhead homologue; surfactant protein A; pulmonary neuroendocrine cells; Notch; laminin


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
S. Tebockhorst, D. Lee, A. S. Wexler, and M. J. Oldham
Interaction of epithelium with mesenchyme affects global features of lung architecture: a computer model of development
J Appl Physiol, January 1, 2007; 102(1): 294 - 305.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
I. F. McMurtry
Editorial: Introduction: pre- and postnatal lung development, maturation, and plasticity
Am J Physiol Lung Cell Mol Physiol, March 1, 2002; 282(3): L341 - L344.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. E. Kling, H. K. Lorenzo, A. M. Trbovich, T. B. Kinane, P. K. Donahoe, and J. J. Schnitzer
Pre- and Postnatal Lung Development, Maturation, and Plasticity: MEK-1/2 inhibition reduces branching morphogenesis and causes mesenchymal cell apoptosis in fetal rat lungs
Am J Physiol Lung Cell Mol Physiol, March 1, 2002; 282(3): L370 - L378.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
L.-A. D. Miller, S. E. Wert, and J. A. Whitsett
Immunolocalization of Sonic Hedgehog (Shh) in Developing Mouse Lung
J. Histochem. Cytochem., December 1, 2001; 49(12): 1593 - 1604.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
C. Zhang, N. B. Sweezey, S. Gagnon, B. Muskat, D. Koehler, M. Post, and F. Kaplan
A Novel Karyopherin-beta Homolog Is Developmentally and Hormonally Regulated in Fetal Lung
Am. J. Respir. Cell Mol. Biol., April 1, 2000; 22(4): 451 - 459.
[Abstract] [Full Text]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
E C JESUDASON, P D LOSTY, and D A LLOYD
Pulmonary hypoplasia: alternative pathogenesis and antenatal therapy in diaphragmatic hernia
Arch. Dis. Child. Fetal Neonatal Ed., March 1, 2000; 82(2): 171F - 171.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online