Segmental microvascular permeabilities were measured using pre- and postalveolar vessel capillary filtration coefficient (K_fc) values (ml · min¹ · cmH₂O¹ · 100 g¹) in isolated rat lungs subjected to ischemia-reperfusion (I/R). Total K_fc values measured in flowing and nonflowing lungs were highly correlated (r = 0.98, P < 0.0001). K_fc values were then measured in another group of lungs under no-flow conditions when airway pressure was increased to 20 cmH₂O and either the arterial or venous pressure was elevated to 7-8 cmH₂O to measure the prealveolar and postalveolar K_fc values. Control total and postalveolar K_fc values were 0.0225 ± 0.001 and 0.0219 ± 0.001 ml · min¹ · cmH₂O¹ · 100 g¹, respectively, and the prealveolar permeability was extremely small (0.00003 ± 0.00005 ml · min¹ · cmH₂O¹ · 100 g¹). K_fc values were again made in nonflowing lungs that had been subjected to 45 min of ischemia followed by 30 min of reperfusion. After I/R, the total membrane K_fc increased 10-fold to 0.2597 ± 0.006 ml · min¹ · cmH₂O¹ · 100 g¹, the prealveolar K_fc increased to 0.0677 ± 0.003 ml · min¹ · cmH₂O¹ · 100 g¹, and the postalveolar K_fc increased to 0.1354 ± 0.008 ml · min¹ · cmH₂O¹ · 100 g¹ (P < 0.05 for all I/R values). These data indicate that normal solvent microvascular permeability was predominantly postalveolar, and after I/R damage, the postalveolar (venular) permeability comprised 52% of the total, whereas the prealveolar and alveolar vessels comprised only 27 and 23%, respectively, of the total K_fc.

alveolar; extra-alveolar permeability; filtration coefficient

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