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Am J Physiol Lung Cell Mol Physiol 277: L881-L886, 1999;
1040-0605/99 $5.00
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Vol. 277, Issue 5, L881-L886, November 1999

Hypoxia reduces airway epithelial sodium transport in rats

L. A. Tomlinson1,2, T. C. Carpenter1, E. H. Baker2, J. B. Bridges1, and J. V. Weil1

1 Cardiovascular-Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver, Colorado 80262; and 2 Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, London, United Kingdom SW17 ORE

Ascent to high altitude leads to pulmonary edema formation in some individuals. Recent laboratory evidence supports the hypothesis that hypoxia may impair the function of the alveolar epithelium and thus augment edema accumulation via reduced clearance of lung liquid. We investigated the effect of hypobaric hypoxia on epithelial sodium transport in adult Sprague-Dawley rats by measuring the nasal transepithelial potential difference (PD) as an index of airway sodium transport. Baseline PDs were similar to those previously reported in other species. Administration of amiloride resulted in a significant fall in nasal PD, as did ouabain administration for 24 h (-27.8 vs. -18.8 mV; P = 0.001; n = 5 rats). Exposure to hypobaric hypoxia (0.5 atm) for 24 h caused a significant fall in nasal PD (-23.7 vs. -18.8 mV; P = 0.002; n = 15 rats), which was not additive to the changes in nasal PD produced by amiloride or ouabain. We conclude that subacute exposure to moderate hypobaric hypoxia can inhibit sodium transport by the airway epithelium in rats.

transepithelial potential difference; ouabain


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