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Am J Physiol Lung Cell Mol Physiol 277: L887-L892, 1999;
1040-0605/99 $5.00
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Vol. 277, Issue 5, L887-L892, November 1999

Newborn intrapulmonary veins are more reactive than arteries in normal and hypertensive piglets

F. I. Arrigoni1, A. A. Hislop1, S. G. Haworth1, and J. A. Mitchell2

1 Developmental Vascular Biology and Pharmacology Unit, Institute of Child Health, London WC1N 1EH; and 2 Unit of Critical Care Medicine, Imperial College School of Medicine, Royal Brompton Hospital, London SW3 6NP, United Kingdom

The reactivity of pulmonary veins during adaptation from pre- to postnatal life is not well characterized. With an in vitro organ bath technique, the responses to the contractile and relaxant agonists U-46619 (10-10 to 3 × 10-6 M) and acetylcholine (10-9 to 10-4 M) were compared in adjacent conduit pulmonary vein and artery rings from 66 piglets aged 1 wk preterm to 14 days of postnatal life and from adult tissue. Five additional piglets were made hypertensive by exposure to chronic hypoxia for 3 days after birth. Both arteries and veins showed smaller contractile and relaxant responses before birth than after. By 5 min after birth, the contraction by arteries and relaxation by veins had increased (P < 0.05). By 3 days of age, arterial relaxation increased, but in all animals, venous relaxation exceeded that in arteries (P < 0.05). Veins contracted more than arteries in animals aged 3-14 days. Neonatal hypoxia diminished the responses to both agonists in the veins (P < 0.05), whereas the response in the arteries remained similar to that in the normal newborn. We speculate that veins may be more important in postnatal adaptation than previously suggested.

development; U-46619; hypoxia; acetylcholine


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