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Am J Physiol Lung Cell Mol Physiol 277: L1214-L1223, 1999;
1040-0605/99 $5.00
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Vol. 277, Issue 6, L1214-L1223, December 1999

Resistance of hypotransferrinemic mice to hyperoxia-induced lung injury

Funmei Yang1, Jacqueline J. Coalson2, Heather H. Bobb1, Jacqueline D. Carter3, Jameela Banu1, and Andrew J. Ghio3

Departments of 1 Cellular and Structural Biology and 2 Pathology, The University of Texas Health Science Center, San Antonio, Texas 78229; and 3 National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina 27711

Oxidative stress plays a central role in the pathogenesis of acute and chronic pulmonary diseases. Safe sequestration of iron, which participates in the formation of the hydroxyl radical, is crucial in the lung's defense. We used a mouse line defective in the major iron transport protein transferrin to investigate the effect of aberrant iron metabolism on the lung's defense against oxidative injury. The tolerance to hyperoxic lung injury was greater in the hypotransferrinemic than in wild-type mice as documented by histopathology and biochemical indexes for lung damage. There was no increase in the levels of intracellular antioxidants, inflammatory cytokines, and heme oxygenase-1 in the hypotransferrinemic mouse lung compared with those in wild-type mice. However, there were elevated expressions of ferritin and lactoferrin in the lung of hypotransferrinemic mice, especially in the alveolar macrophages. Our results suggest that pulmonary lactoferrin and ferritin protect animals against oxidative stress, most likely via their capacity to sequester iron, and that alveolar macrophages are the key participants in iron detoxification in the lower respiratory tract.

iron metabolism; lactoferrin; transferrin; ferritin; antioxidants


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