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1 Department of Molecular Medicine and 4 Division of Gene Therapy Science, Osaka University Medical School, Suita, Osaka 565-0871; 2 Department of Pulmonary Disease, Higashiosaka City General Hospital, Higashiosaka 578-8588, Japan; and 3 Department of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039
Interleukin (IL)-10 has been shown to reduce many
inflammatory reactions. We investigated the in vivo effects of IL-10 on a bleomycin-induced lung injury model. Hemagglutinating virus of Japan
(HVJ)-liposomes containing a human IL-10 expression vector (hIL10-HVJ)
or a balanced salt solution as a control (Cont-HVJ) was
intraperitoneally injected into mice on day 
3. This was
followed by intratracheal instillation of bleomycin (0.8 mg/kg) on
day 0. Myeloperoxidase activity of bronchoalveolar lavage fluid
and tumor necrosis factor-
mRNA expression in bronchoalveolar lavage fluid cells on day 7 and hydroxyproline content of the whole
lung on day 21 were inhibited significantly by hIL10-HVJ
treatment. However, Cont-HVJ treatment could not suppress any of these
parameters. We also examined the in vitro effects of IL-10 on the human
lung fibroblast cell line WI-38. IL-10 significantly reduced
constitutive and transforming growth factor-
-stimulated type I
collagen mRNA expression. However, IL-10 did not affect the
proliferation of WI-38 cells induced by platelet-derived growth factor.
These data suggested that exogenous IL-10 may be useful in the
treatment of pulmonary fibrosis.
transforming growth factor-; pulmonary fibrosis; collagen
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