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Meakins-Christie Laboratories, Montreal Chest Institute Research Centre, McGill University Health Centre, McGill University, Montreal, Quebec, Canada H2X 2P2
Airway surface liquid (ASL) lines the conducting airways
of the respiratory tract. We collected small samples of this liquid from the lower tracheae of anesthetized C57BL/6 mice and
determined its ionic composition (in mM: 87.2 Na+, 4.7 K+, and 57.0 Cl
). Intravenous
methacholine produced significant increases in the concentrations of
Na+, K+, and Cl within ASL.
A limited analysis of liquid from cystic fibrosis transmembrane
conductance regulator (CFTR) knockout mice revealed no significant
differences compared with littermate controls; however, Pseudomonas
aeruginosa infection led to an increase in the salt concentration
of ASL in cftr(+/+) mice. Morphometric measurements of tracheal
submucosal gland volume revealed significant differences between inbred
mouse strains, corresponding to ease of ASL collection. We conclude
that although submucosal glands may be responsible for the production
of some ASL, the ionic composition of this liquid is actively regulated
by the underlying epithelial cells.
Pseudomonas aeruginosa; cystic fibrosis; submucosal gland
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