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-based Th1 response in thoracic lymph nodes
Institute of Immunology, Philipps University, D-35037 Marburg, Germany
In chronic
silicosis, mechanisms leading to lymphocyte activation are still poorly
understood, although it is well known that not only the lung but also
the draining lymph nodes are affected. In the present study, we
investigated T-cell activation by analysis of cytokine expression in
the enlarged thoracic lymph nodes of rats 2 mo after an 8-day silica
aerosol exposure. In the case of helper T cell (Th) type 1 cytokines, we found a significant increase in interferon (IFN)-
mRNA
expression, whereas interleukin (IL)-2 expression remained unchanged.
In contrast, gene transcription for the Th2-type cytokines IL-4 and
IL-10 was diminished. In addition, with use of an in vitro
lymphocyte-macrophage coculture system, an enhanced IFN- and a
reduced IL-10 release were shown with cells from silicotic animals.
With regard to IFN--inducing cytokines, we observed enhanced IL-12
mRNA levels in vivo, whereas IL-18 gene expression was slightly
decreased. These data indicate that a persistent shift toward an
IFN--dominated type 1 (Th1/cytotoxic T cell type 1) T-cell reaction
pattern occurred within the thoracic lymph nodes of silicotic animals.
Thus a mutual activation of lymphocytes and macrophages may maintain
the chronic inflammatory changes that characterize silicosis.
interferon-; chronic lung inflammation; particles; T
lymphocytes; cytokines; interleukins; helper T cell type 1
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