| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, and 6 Department of Basic Science and Oral Research, School of Dentistry, University of Colorado Health Sciences Center, Denver 80262; 2 Denver Veterans Affairs Medical Center, Denver, Colorado 80220; 3 Department of Pharmacology, University of California, San Diego, La Jolla 92093; 4 Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford 94305; 7 Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608; and 5 Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555
Individual protein kinase C (PKC) isozymes have been implicated in many cellular responses important in lung health and disease, including permeability, contraction, migration, hypertrophy, proliferation, apoptosis, and secretion. New ideas on mechanisms that regulate PKC activity, including the identification of a novel PKC kinase, 3-phosphoinositide-dependent kinase-1 (PDK-1), that regulates phosphorylation of PKC, have been advanced. The importance of targeted translocation of PKC and isozyme-specific binding proteins (like receptors for activated C-kinase and caveolins) is well established. Phosphorylation state and localization are now thought to be key determinants of isozyme activity and specificity. New concepts on the role of individual PKC isozymes in proliferation and apoptosis are emerging. Opposing roles for selected isozymes in the same cell system have been defined. Coupling to the Wnt signaling pathway has been described. Phenotypes for PKC knockout mice have recently been reported. More specific approaches for studying PKC isozymes and their role in cell responses have been developed. Strengths and weaknesses of different experimental strategies are reviewed. Future directions for investigation are identified.
pulmonary disease; proliferation; apoptosis; 3-phosphoinositide-dependent kinase-1; receptor for activated C-kinase; transgenic mice
This article has been cited by other articles:
|
|
 |
|
  H. Raveh-Amit, A. Maissel, J. Poller, L. Marom, O. Elroy-Stein, M. Shapira, and E. Livneh Translational Control of Protein Kinase C{eta} by Two Upstream Open Reading Frames Mol. Cell. Biol., November 15, 2009; 29(22): 6140 - 6148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Menne, M. Meier, J.-K. Park, and H. Haller Inhibition of protein kinase C in diabetic nephropathy--where do we stand? Nephrol. Dial. Transplant., July 1, 2009; 24(7): 2021 - 2023. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Q. van der Merwe, F. Moreau, and W. K. MacNaughton Protease-activated receptor-2 stimulates intestinal epithelial chloride transport through activation of PLC and selective PKC isoforms Am J Physiol Gastrointest Liver Physiol, June 1, 2009; 296(6): G1258 - G1266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Lima, C. Niger, C. Hebert, and J. P. Stains Connexin43 Potentiates Osteoblast Responsiveness to Fibroblast Growth Factor 2 via a Protein Kinase C-Delta/Runx2-dependent Mechanism Mol. Biol. Cell, June 1, 2009; 20(11): 2697 - 2708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ghoul, M. Serova, L. Astorgues-Xerri, I. Bieche, G. Bousquet, M. Varna, M. Vidaud, E. Phillips, S. Weill, K. A. Benhadji, et al. Epithelial-to-Mesenchymal Transition and Resistance to Ingenol 3-Angelate, a Novel Protein Kinase C Modulator, in Colon Cancer Cells Cancer Res., May 15, 2009; 69(10): 4260 - 4269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Chari, T. Getz, B. Nagy Jr, K. Bhavaraju, Y. Mao, Y. S. Bynagari, S. Murugappan, K. Nakayama, and S. P. Kunapuli Protein Kinase C{delta} Differentially Regulates Platelet Functional Responses Arterioscler Thromb Vasc Biol, May 1, 2009; 29(5): 699 - 705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Gross, I. Karagiannides, T. Thomou, H. W. Koon, C. Bowe, H. Kim, N. Giorgadze, T. Tchkonia, T. Pirtskhalava, J. L. Kirkland, et al. Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways Am J Physiol Gastrointest Liver Physiol, May 1, 2009; 296(5): G1012 - G1019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang, H. Zhao, S. Asztalos, M. Chisamore, Y. Sitabkhan, and D. A. Tonetti Estradiol-Induced Regression in T47D:A18/PKC{alpha} Tumors Requires the Estrogen Receptor and Interaction with the Extracellular Matrix Mol. Cancer Res., April 1, 2009; 7(4): 498 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sun, R. D. Ramnath, R. Tamizhselvi, and M. Bhatia Role of protein kinase C and phosphoinositide 3-kinase-Akt in substance P-induced proinflammatory pathways in mouse macrophages FASEB J, April 1, 2009; 23(4): 997 - 1010. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Patten and M. R. Hall-Porter Small Animal Models of Heart Failure: Development of Novel Therapies, Past and Present Circ Heart Fail, March 1, 2009; 2(2): 138 - 144. [Full Text] [PDF]
|
|
|
|
|
|
E. E.W. Cohen, H. Zhu, M. W. Lingen, L. E. Martin, W.-L. Kuo, E. A. Choi, M. Kocherginsky, J. S. Parker, C. H. Chung, and M. R. Rosner A Feed-Forward Loop Involving Protein Kinase C{alpha} and MicroRNAs Regulates Tumor Cell Cycle Cancer Res., January 1, 2009; 69(1): 65 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Villar, H. S. Quadri, I. Song, Y. Tomita, O. M. Tirado, and V. Notario PCPH/ENTPD5 Expression Confers to Prostate Cancer Cells Resistance against Cisplatin-Induced Apoptosis through Protein Kinase C{alpha}-Mediated Bcl-2 Stabilization Cancer Res., January 1, 2009; 69(1): 102 - 110. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Armstrong, A. Pereverzev, S. J. Dixon, and S. M. Sims Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts J. Cell Sci., January 1, 2009; 122(1): 136 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Perry, D. O. Quissell, M. E. Reyland, and I. I. Grichtchenko Electrogenic NBCe1 (SLC4A4), but not electroneutral NBCn1 (SLC4A7), cotransporter undergoes cholinergic-stimulated endocytosis in salivary ParC5 cells Am J Physiol Cell Physiol, November 1, 2008; 295(5): C1385 - C1398. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Steinberg Structural Basis of Protein Kinase C Isoform Function Physiol Rev, October 1, 2008; 88(4): 1341 - 1378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Davis, M. V. Westfall, D. Townsend, M. Blankinship, T. J. Herron, G. Guerrero-Serna, W. Wang, E. Devaney, and J. M. Metzger Designing Heart Performance by Gene Transfer Physiol Rev, October 1, 2008; 88(4): 1567 - 1651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Sakai, H. Terami, S. Suzuki, M. Haga, K. Nomoto, N. Tsuchida, K.-i. Morohashi, N. Saito, M. Asada, M. Hashimoto, et al. Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies J. Endocrinol., September 1, 2008; 198(3): 489 - 497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Smani, T. Patel, and V. M. Bolotina Complex regulation of store-operated Ca2+ entry pathway by PKC-{varepsilon} in vascular SMCs Am J Physiol Cell Physiol, June 1, 2008; 294(6): C1499 - C1508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J Delvecchio and J. P Capone Protein kinase C {alpha} modulates liver X receptor {alpha} transactivation J. Endocrinol., April 1, 2008; 197(1): 121 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Zhiyong Zhao, Y.-K. Wu, and E. A. Reece Demonstration of the Essential Role of Protein Kinase C Isoforms in Hyperglycemia-Induced Embryonic Malformations Reproductive Sciences, April 1, 2008; 15(4): 349 - 356. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Slevogt, L. Maqami, K. Vardarowa, W. Beermann, A. C. Hocke, J. Eitel, B. Schmeck, A. Weimann, B. Opitz, S. Hippenstiel, et al. Differential regulation of Moraxella catarrhalis-induced interleukin-8 response by protein kinase C isoforms Eur. Respir. J., April 1, 2008; 31(4): 725 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Ramnath, J. Sun, S. Adhikari, L. Zhi, and M. Bhatia Role of PKC-{delta} on substance P-induced chemokine synthesis in pancreatic acinar cells Am J Physiol Cell Physiol, March 1, 2008; 294(3): C683 - C692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. D'Souza, N. N. Petrashevskaya, W. H. Merrill, and S. A. Akhter Inhibition of protein kinase C{alpha} improves myocardial -adrenergic receptor signaling and ventricular function in a model of myocardial preservation J. Thorac. Cardiovasc. Surg., January 1, 2008; 135(1): 172 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Amos, M. Mut, C. G. diPierro, J. E. Carpenter, A. Xiao, Z. A. Kohutek, G. T. Redpath, Y. Zhao, J. Wang, M. E. Shaffrey, et al. Protein Kinase C-{alpha} Mediated Regulation of Low-Density Lipoprotein Receptor Related Protein and Urokinase Increases Astrocytoma Invasion Cancer Res., November 1, 2007; 67(21): 10241 - 10251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Meier, J. Menne, J.-K. Park, and H. Haller Nailing down PKC isoform specificity in diabetic nephropathy two's company, three's a crowd Nephrol. Dial. Transplant., September 1, 2007; 22(9): 2421 - 2425. [Full Text] [PDF]
|
|
|
|
|
|
K.-M. Bae, H. Wang, G. Jiang, M. G. Chen, L. Lu, and L. Xiao Protein Kinase C{varepsilon} Is Overexpressed in Primary Human Non-Small Cell Lung Cancers and Functionally Required for Proliferation of Non-Small Cell Lung Cancer Cells in a p21/Cip1-Dependent Manner Cancer Res., July 1, 2007; 67(13): 6053 - 6063. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. House, S. J. Melhorn, G. Newman, T. Doetschman, and J. E. J. Schultz The protein kinase C pathway mediates cardioprotection induced by cardiac-specific overexpression of fibroblast growth factor-2 Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H354 - H365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Reppel, B. K. Fleischmann, H. Reuter, P. Sasse, H. Schunkert, and J. Hescheler Regulation of the Na+/Ca2+ exchanger (NCX) in the murine embryonic heart Cardiovasc Res, July 1, 2007; 75(1): 99 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gomel, C. Xiang, S. Finniss, H. K. Lee, W. Lu, H. Okhrimenko, and C. Brodie The Localization of Protein Kinase C{delta} in Different Subcellular Sites Affects Its Proapoptotic and Antiapoptotic Functions and the Activation of Distinct Downstream Signaling Pathways Mol. Cancer Res., June 1, 2007; 5(6): 627 - 639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Clavijo, J.-L. Chen, K.-J. Kim, M. E. Reyland, and D. K. Ann Protein kinase C{delta}-dependent and -independent signaling in genotoxic response to treatment of desferroxamine, a hypoxia-mimetic agent Am J Physiol Cell Physiol, June 1, 2007; 292(6): C2150 - C2160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Zhang, A. Kanthasamy, Y. Yang, V. Anantharam, and A. Kanthasamy Protein Kinase C{delta} Negatively Regulates Tyrosine Hydroxylase Activity and Dopamine Synthesis by Enhancing Protein Phosphatase-2A Activity in Dopaminergic Neurons J. Neurosci., May 16, 2007; 27(20): 5349 - 5362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Meier, J. Menne, J.-K. Park, M. Holtz, F. Gueler, T. Kirsch, M. Schiffer, M. Mengel, C. Lindschau, M. Leitges, et al. Deletion of Protein Kinase C-{varepsilon} Signaling Pathway Induces Glomerulosclerosis and Tubulointerstitial Fibrosis In Vivo J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1190 - 1198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Preiss, D. Namgaladze, and B. Brune Critical role for classical PKC in activating Akt by phospholipase A2-modified LDL in monocytic cells Cardiovasc Res, March 1, 2007; 73(4): 833 - 840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Meier, J.-K. Park, D. Overheu, T. Kirsch, C. Lindschau, F. Gueler, M. Leitges, J. Menne, and H. Haller Deletion of Protein Kinase C-{beta} Isoform In Vivo Reduces Renal Hypertrophy but Not Albuminuria in the Streptozotocin-Induced Diabetic Mouse Model Diabetes, February 1, 2007; 56(2): 346 - 354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Abrams, T. Lakum, K. Lin, G. M. Jones, A. T. Treweeke, M. Farahani, M. Hughes, M. Zuzel, and J. R. Slupsky B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase C{beta}II Blood, February 1, 2007; 109(3): 1193 - 1201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-Y. Park, H.-W. Kang, H.-J. Moon, S.-U. Huh, S.-W. Jeong, N. M. Soldatov, and J.-H. Lee Activation of protein kinase C augments T-type Ca2+ channel activity without changing channel surface density J. Physiol., December 1, 2006; 577(2): 513 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, M. Liao, and M. L. Dufau Phosphatidylinositol 3-Kinase/Protein Kinase C{zeta}-Induced Phosphorylation of Sp1 and p107 Repressor Release Have a Critical Role in Histone Deacetylase Inhibitor-Mediated Depression of Transcription of the Luteinizing Hormone Receptor Gene. Mol. Cell. Biol., September 1, 2006; 26(18): 6748 - 6761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Satoh, A. S. Gukovskaya, J. R. Reeve Jr, T. Shimosegawa, and S. J. Pandol Ethanol sensitizes NF-{kappa}B activation in pancreatic acinar cells through effects on protein kinase C-{epsilon} Am J Physiol Gastrointest Liver Physiol, September 1, 2006; 291(3): G432 - G438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hambleton, H. Hahn, S. T. Pleger, M. C. Kuhn, R. Klevitsky, A. N. Carr, T. F. Kimball, T. E. Hewett, G. W. Dorn II, W. J. Koch, et al. Pharmacological- and Gene Therapy-Based Inhibition of Protein Kinase C{alpha}/{beta} Enhances Cardiac Contractility and Attenuates Heart Failure Circulation, August 8, 2006; 114(6): 574 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Lin, Y. Yu, H. Zhao, Y. Zhang, J. Manela, and D. A. Tonetti Overexpression of PKC{alpha} is required to impart estradiol inhibition and tamoxifen-resistance in a T47D human breast cancer tumor model Carcinogenesis, August 1, 2006; 27(8): 1538 - 1546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Le, L. Krilov, J. Meng, K. Chapin-Kennedy, S. Ceryak, and B. Bouscarel Bile acids stimulate PKC{alpha} autophosphorylation and activation: role in the attenuation of prostaglandin E1-induced cAMP production in human dermal fibroblasts Am J Physiol Gastrointest Liver Physiol, August 1, 2006; 291(2): G275 - G287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Oster and M. Leitges Protein Kinase C {alpha} but not PKC{zeta} Suppresses Intestinal Tumor Formation in ApcMin/+ Mice. Cancer Res., July 15, 2006; 66(14): 6955 - 6963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Mukherjee, K. A. Apple, C. E. Squires, B. S. Kaplan, J. E. McLean, S. M. Saunders, R. E. Stroud, and F. G. Spinale Protein Kinase C Isoform Activation and Endothelin-1 Mediated Defects in Myocyte Contractility After Cardioplegic Arrest and Reperfusion Circulation, July 4, 2006; 114(1_suppl): I-308 - I-313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. W. Cohen, M. W. Lingen, B. Zhu, H. Zhu, M. W. Straza, C. Pierce, L. E. Martin, and M. R. Rosner Protein Kinase C{zeta} Mediates Epidermal Growth Factor-Induced Growth of Head and Neck Tumor Cells by Regulating Mitogen-Activated Protein Kinase. Cancer Res., June 15, 2006; 66(12): 6296 - 6303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhang, J. Huang, N. Yang, S. Liang, A. Barchetti, A. Giannakakis, M. G. Cadungog, A. O'Brien-Jenkins, M. Massobrio, K. F. Roby, et al. Integrative Genomic Analysis of Protein Kinase C (PKC) Family Identifies PKC{iota} as a Biomarker and Potential Oncogene in Ovarian Carcinoma. Cancer Res., May 1, 2006; 66(9): 4627 - 4635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Fang, Y. Huang, and Z. Zuo Enhancement of substrate-gated Cl- currents via rat glutamate transporter EAAT4 by PMA Am J Physiol Cell Physiol, May 1, 2006; 290(5): C1334 - C1340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Warwar, S. Efendic, C.-G. Ostenson, E. P. Haber, E. Cerasi, and R. Nesher Dynamics of Glucose-Induced Localization of PKC Isoenzymes in Pancreatic {beta}-Cells: Diabetes-Related Changes in the GK Rat Diabetes, March 1, 2006; 55(3): 590 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ding, C. Huang, Y. Lu, L. Bowman, V. Castranova, and V. Vallyathan Involvement of protein kinase C in crystalline silica-induced activation of the MAP kinase and AP-1 pathway Am J Physiol Lung Cell Mol Physiol, February 1, 2006; 290(2): L291 - L297. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hashim, G. Mulcahy, B. Bourke, and M. Clyne Interaction of Cryptosporidium hominis and Cryptosporidium parvum with Primary Human and Bovine Intestinal Cells Infect. Immun., January 1, 2006; 74(1): 99 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhao and E. A. Reece Experimental Mechanisms of Diabetic Embryopathy and Strategies for Developing Therapeutic Interventions Reproductive Sciences, December 1, 2005; 12(8): 549 - 557. [Abstract] [PDF]
|
|
|
|
|
|
C. M. Littler, C. A. Wehling, M. J. Wick, K. A. Fagan, C. D. Cool, R. O. Messing, and E. C. Dempsey Divergent contractile and structural responses of the murine PKC-{epsilon} null pulmonary circulation to chronic hypoxia Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L1083 - L1093. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Ron and R. Jurd The "Ups and Downs" of Signaling Cascades in Addiction Sci. Signal., November 8, 2005; 2005(309): re14 - re14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. C. Del Castillo, M. Fedor-Chaiken, J. C. Song, V. Starlinger, J. Yoo, K. S. Matlin, and J. B. Matthews Dynamic regulation of Na+-K+-2Cl- cotransporter surface expression by PKC-{epsilon} in Cl--secretory epithelia Am J Physiol Cell Physiol, November 1, 2005; 289(5): C1332 - C1343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Dehghani, C. Reith, and A. C Hahnel Subcellular localization of protein kinase C {delta} and {varepsilon} affects transcriptional and post-transcriptional processes in four-cell mouse embryos Reproduction, October 1, 2005; 130(4): 453 - 465. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Partovian, Z. Zhuang, K. Moodie, M. Lin, N. Ouchi, W. C. Sessa, K. Walsh, and M. Simons PKC{alpha} Activates eNOS and Increases Arterial Blood Flow In Vivo Circ. Res., September 2, 2005; 97(5): 482 - 487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Hampson, H. Chahal, F. Khanim, R. Hayden, A. Mulder, L. K. Assi, C. M. Bunce, and J. M. Lord PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC Blood, August 15, 2005; 106(4): 1362 - 1368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wilmanski, M. Siddiqi, E. A. Deitch, and Z. Spolarics Augmented IL-10 production and redox-dependent signaling pathways in glucose-6-phosphate dehydrogenase-deficient mouse peritoneal macrophages J. Leukoc. Biol., July 1, 2005; 78(1): 85 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Galindo, A. A. Fadl, J. Sha, L. Pillai, C. Gutierrez Jr., and A. K. Chopra Microarray and Proteomics Analyses of Human Intestinal Epithelial Cells Treated with the Aeromonas hydrophila Cytotoxic Enterotoxin Infect. Immun., May 1, 2005; 73(5): 2628 - 2643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Seki, H. Matsubayashi, T. Amano, Y. Shirai, N. Saito, and N. Sakai Phosphorylation of PKC activation loop plays an important role in receptor-mediated translocation of PKC Genes Cells, March 1, 2005; 10(3): 225 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Randriamboavonjy, L. Kiss, J. R. Falck, R. Busse, and I. Fleming The synthesis of 20-HETE in small porcine coronary arteries antagonizes EDHF-mediated relaxation Cardiovasc Res, February 1, 2005; 65(2): 487 - 494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J Rose, B. J Michell, B. E Kemp, and M. Hargreaves Effect of exercise on protein kinase C activity and localization in human skeletal muscle J. Physiol., December 15, 2004; 561(3): 861 - 870. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Fimia, C. Evangelisti, T. Alonzi, M. Romani, F. Fratini, G. Paonessa, G. Ippolito, M. Tripodi, and M. Piacentini Conventional Protein Kinase C Inhibition Prevents Alpha Interferon-Mediated Hepatitis C Virus Replicon Clearance by Impairing STAT Activation J. Virol., December 1, 2004; 78(23): 12809 - 12816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Satoh, A. S. Gukovskaya, J. M. Nieto, J. H. Cheng, I. Gukovsky, J. R. Reeve Jr, T. Shimosegawa, and S. J. Pandol PKC-{delta} and -{epsilon} regulate NF-{kappa}B activation induced by cholecystokinin and TNF-{alpha} in pancreatic acinar cells Am J Physiol Gastrointest Liver Physiol, September 1, 2004; 287(3): G582 - G591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Wheaton and K. Riabowol Protein Kinase C{delta} Blocks Immediate-Early Gene Expression in Senescent Cells by Inactivating Serum Response Factor Mol. Cell. Biol., August 15, 2004; 24(16): 7298 - 7311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-X. Wang, C. McCrudden, Y.-P. Dai, B. Horowitz, J. R. Hume, and I. A. Yamboliev Hypotonic activation of volume-sensitive outwardly rectifying chloride channels in cultured PASMCs is modulated by SGK Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H533 - H544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-Y. Park, H. Wu, C. E. Killoran, and B. A. Gilchrest The receptor for activated C-kinase-I (RACK-I) anchors activated PKC-{beta} on melanosomes J. Cell Sci., July 15, 2004; 117(16): 3659 - 3668. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. N. Pandey, Y. Dwivedi, H. S. Rizavi, X. Ren, and R. R. Conley Decreased Catalytic Activity and Expression of Protein Kinase C Isozymes in Teenage Suicide Victims: A Postmortem Brain Study Arch Gen Psychiatry, July 1, 2004; 61(7): 685 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Liu, M. L. Godwin, and G. Nowak Protein kinase C-{alpha} inhibits the repair of oxidative phosphorylation after S-(1,2-dichlorovinyl)-L-cysteine injury in renal cells Am J Physiol Renal Physiol, July 1, 2004; 287(1): F64 - F73. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. U. Rao, H. Shiraishi, and P. J. McDermott PKC-{epsilon} regulation of extracellular signal-regulated kinase: a potential role in phenylephrine-induced cardiocyte growth Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2195 - H2203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kedei, D. J. Lundberg, A. Toth, P. Welburn, S. H. Garfield, and P. M. Blumberg Characterization of the Interaction of Ingenol 3-Angelate with Protein Kinase C Cancer Res., May 1, 2004; 64(9): 3243 - 3255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Brehmer, K. Godl, B. Zech, J. Wissing, and H. Daub Proteome-wide Identification of Cellular Targets Affected by Bisindolylmaleimide-type Protein Kinase C Inhibitors Mol. Cell. Proteomics, May 1, 2004; 3(5): 490 - 500. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. O. Rybin, J. Guo, A. Sabri, H. Elouardighi, E. Schaefer, and S. F. Steinberg Stimulus-specific Differences in Protein Kinase C{delta} Localization and Activation Mechanisms in Cardiomyocytes J. Biol. Chem., April 30, 2004; 279(18): 19350 - 19361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. SPAT and L. HUNYADY Control of Aldosterone Secretion: A Model for Convergence in Cellular Signaling Pathways Physiol Rev, April 1, 2004; 84(2): 489 - 539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Nowak, D. Bakajsova, and G. L. Clifton Protein kinase C-{epsilon} modulates mitochondrial function and active Na+ transport after oxidant injury in renal cells Am J Physiol Renal Physiol, February 1, 2004; 286(2): F307 - F316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Sun, G. Mao, and A. K. Rao Association of CBFA2 mutation with decreased platelet PKC-{theta} and impaired receptor-mediated activation of GPIIb-IIIa and pleckstrin phosphorylation: proteins regulated by CBFA2 play a role in GPIIb-IIIa activation Blood, February 1, 2004; 103(3): 948 - 954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Parker and J. Murray-Rust PKC at a glance J. Cell Sci., January 15, 2004; 117(2): 131 - 132. [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Wu, L. Xiao, X.-K. Cheng, L.-X. Cui, N.-H. Wu, and Y.-F. Shen PKC{epsilon} Is a Unique Regulator for hsp90{beta} Gene in Heat Shock Response J. Biol. Chem., December 19, 2003; 278(51): 51143 - 51149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Jossin, M. Ogawa, C. Metin, F. Tissir, and A. M. Goffinet Inhibition of Src Family Kinases and Non-Classical Protein Kinases C Induce a Reeler-Like Malformation of Cortical Plate Development J. Neurosci., October 29, 2003; 23(30): 9953 - 9959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lenasi, K. Kohlstedt, B. Fichtlscherer, A. Mulsch, R. Busse, and I. Fleming Amlodipine activates the endothelial nitric oxide synthase by altering phosphorylation on Ser1177 and Thr495 Cardiovasc Res, October 1, 2003; 59(4): 844 - 853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Y. Choi, N. L. Siow, A. W. M. Cheng, K. K. Y. Ling, E. K. K. Tung, J. Simon, E. A. Barnard, and K. W. K. Tsim ATP Acts via P2Y1 Receptors to Stimulate Acetylcholinesterase and Acetylcholine Receptor Expression: Transduction and Transcription Control J. Neurosci., June 1, 2003; 23(11): 4445 - 4456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Littler, K. G. Morris Jr., K. A. Fagan, I. F. McMurtry, R. O. Messing, and E. C. Dempsey Protein kinase C-epsilon -null mice have decreased hypoxic pulmonary vasoconstriction Am J Physiol Heart Circ Physiol, April 1, 2003; 284(4): H1321 - H1331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Luo, S. M. Prescott, and M. K. Topham Association of diacylglycerol kinase {zeta} with protein kinase C {alpha}: spatial regulation of diacylglycerol signaling J. Cell Biol., March 17, 2003; 160(6): 929 - 937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Siflinger-Birnboim and A. Johnson Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury Am J Physiol Lung Cell Mol Physiol, March 1, 2003; 284(3): L435 - L451. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Reisinger, R. Kaufmann, and J. Gille Increased Sp1 phosphorylation as a mechanism of hepatocyte growth factor (HGF/SF)-induced vascular endothelial growth factor (VEGF/VPF) transcription J. Cell Sci., January 15, 2003; 116(2): 225 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Guo, M. H. Wu, F. Korompai, and S. Y. Yuan Upregulation of PKC genes and isozymes in cardiovascular tissues during early stages of experimental diabetes Physiol Genomics, January 15, 2003; 12(2): 139 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Waldron and E. Rozengurt Protein Kinase C Phosphorylates Protein Kinase D Activation Loop Ser744 and Ser748 and Releases Autoinhibition by the Pleckstrin Homology Domain J. Biol. Chem., January 3, 2003; 278(1): 154 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nanjundan and F. Possmayer Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase Am J Physiol Lung Cell Mol Physiol, January 1, 2003; 284(1): L1 - L23. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Garcia-Garcia and C. Rosales Signal transduction during Fc receptor-mediated phagocytosis J. Leukoc. Biol., December 1, 2002; 72(6): 1092 - 1108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Coyne, M. K. Vanhook, T. M. Gambling, J. L. Carson, R. C. Boucher, and L. G. Johnson Regulation of Airway Tight Junctions by Proinflammatory Cytokines Mol. Biol. Cell, September 1, 2002; 13(9): 3218 - 3234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-Q. Zhao and J. Vinten-Johansen Myocardial apoptosis and ischemic preconditioning Cardiovasc Res, August 15, 2002; 55(3): 438 - 455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zrachia, M. Dobroslav, M. Blass, G. Kazimirsky, I. Kronfeld, P. M. Blumberg, D. Kobiler, S. Lustig, and C. Brodie Infection of Glioma Cells with Sindbis Virus Induces Selective Activation and Tyrosine Phosphorylation of Protein Kinase C delta . IMPLICATIONS FOR SINDBIS VIRUS-INDUCED APOPTOSIS J. Biol. Chem., June 21, 2002; 277(26): 23693 - 23701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-H. Disatnik, S. C. Boutet, C. H. Lee, D. Mochly-Rosen, and T. A. Rando Sequential activation of individual PKC isozymes in integrin-mediated muscle cell spreading: a role for MARCKS in an integrin signaling pathway J. Cell Sci., May 15, 2002; 115(10): 2151 - 2163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Slater, J. L. Seiz, A. C. Cook, C. J. Buzas, S. A. Malinowski, J. L. Kershner, B. A. Stagliano, and C. D. Stubbs Regulation of PKCalpha Activity by C1-C2 Domain Interactions J. Biol. Chem., May 3, 2002; 277(18): 15277 - 15285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Hendey, C. L. Zhu, and S. Greenstein Fas activation opposes PMA-stimulated changes in the localization of PKC{delta}: a mechanism for reducing neutrophil adhesion to endothelial cells J. Leukoc. Biol., May 1, 2002; 71(5): 863 - 870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Morigi, D. Macconi, C. Zoja, R. Donadelli, S. Buelli, C. Zanchi, M. Ghilardi, and G. Remuzzi Protein Overload-Induced NF-{kappa}B Activation in Proximal Tubular Cells Requires H2O2 through a PKC-Dependent Pathway J. Am. Soc. Nephrol., May 1, 2002; 13(5): 1179 - 1189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Braz, O. F. Bueno, L. J. De Windt, and J. D. Molkentin PKC{alpha} regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2) J. Cell Biol., March 4, 2002; 156(5): 905 - 919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Guha, O. Rey, and E. Rozengurt Neurotensin Induces Protein Kinase C-dependent Protein Kinase D Activation and DNA Synthesis in Human Pancreatic Carcinoma Cell Line PANC-1 Cancer Res., March 1, 2002; 62(6): 1632 - 1640. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
