AJP - Lung Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 279: L562-L574, 2000;
1040-0605/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Selman, M.
Right arrow Articles by Pardo, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Selman, M.
Right arrow Articles by Pardo, A.
Vol. 279, Issue 3, L562-L574, September 2000

TIMP-1, -2, -3, and -4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment?

Moises Selman1, Victor Ruiz1, Sandra Cabrera2, Lourdes Segura1, Remedios Ramírez2, Roberto Barrios3, and Annie Pardo2

2 Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Coyocán México DF CP 04000; 1 Instituto Nacional de Enfermedades Respiratorias, México DF CP 14080, Mexico; and 3 Department of Pathology, Baylor College of Medicine, Houston, Texas 77030

Fibroblast proliferation and extracellular matrix accumulation characterize idiopathic pulmonary fibrosis (IPF). We evaluated the presence of tissue inhibitor of metalloproteinase (TIMP)-1, -2, -3, and -4; collagenase-1, -2, and -3; gelatinases A and B; and membrane type 1 matrix metalloproteinase (MMP) in 12 IPF and 6 control lungs. TIMP-1 was found in interstitial macrophages and TIMP-2 in fibroblast foci. TIMP-3 revealed an intense staining mainly decorating the elastic lamina in vessels. TIMP-4 was expressed in IPF lungs by epithelial and plasma cells. TIMP-2 colocalized with Ki67 in fibroblasts, whereas TIMP-3 colocalized with p27 in inflammatory and epithelial cells. Collagenase-1 was localized in macrophages and alveolar epithelial cells, collagenase-2 was localized in a few neutrophils, and collagenase-3 was not detected. MMP-9 was found in neutrophils and subepithelial myofibroblasts. Myofibroblast expression of MMP-9 was corroborated in vitro by RT-PCR. MMP-2 was noticed in myofibroblasts, some of them close to areas of basement membrane disruption, and membrane type 1 MMP was noticed in interstitial macrophages. These findings suggest that in IPF there is higher expression of TIMPs compared with collagenases, supporting the hypothesis that a nondegrading fibrillar collagen microenvironment is prevailing.

tissue inhibitor of metalloproteinases; gelatinases; collagenase; fibrosis


This article has been cited by other articles:


Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. J. Schuliga, I. See, S. C. Ong, L. Soon, B. Camoretti-Mercado, T. Harris, and A. G. Stewart
Fibrillar Collagen Clamps Lung Mesenchymal Cells in a Nonproliferative and Noncontractile Phenotype
Am. J. Respir. Cell Mol. Biol., December 1, 2009; 41(6): 731 - 741.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
A. M. Macgregor, C. G. Eberhart, M. Fraig, J. Lu, and M. K. Halushka
Tissue Inhibitor of Matrix Metalloproteinase-3 Levels in the Extracellular Matrix of Lung, Kidney, and Eye Increase With Age
J. Histochem. Cytochem., March 1, 2009; 57(3): 207 - 213.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
G. P. Cosgrove and R. M. du Bois
Matrix Metalloproteinase-7 Expression in Fibrosing Lung Disease: Restoring the Balance
Chest, May 1, 2008; 133(5): 1058 - 1060.
[Full Text] [PDF]

Home page
 ChestHome page
J. W. Huh, D. S. Kim, Y.-M. Oh, T. S. Shim, C. M. Lim, S. D. Lee, Y. Koh, W. S. Kim, W. D. Kim, and K. R. Kim
Is Metalloproteinase-7 Specific for Idiopathic Pulmonary Fibrosis?
Chest, May 1, 2008; 133(5): 1101 - 1106.
[Abstract] [Full Text] [PDF]

Home page
 Ther Adv Respir DisHome page
P. Rogliani, M. Mura, M. Assunta Porretta, and C. Saltini
Review: New perspectives in the treatment of idiopathic pulmonary fibrosis
Therapeutic Advances in Respiratory Disease, April 1, 2008; 2(2): 75 - 93.
[Abstract] [PDF]

Home page
 Infect. Immun.Home page
J.-F. Marquis, A. Nantel, R. LaCourse, L. Ryan, R. J. North, and P. Gros
Fibrotic Response as a Distinguishing Feature of Resistance and Susceptibility to Pulmonary Infection with Mycobacterium tuberculosis in Mice
Infect. Immun., January 1, 2008; 76(1): 78 - 88.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. Pottier, C. Chupin, V. Defamie, B. Cardinaud, R. Sutherland, G. Rios, F. Gauthier, P. J. Wolters, Y. Berthiaume, P. Barbry, et al.
Relationships between Early Inflammatory Response to Bleomycin and Sensitivity to Lung Fibrosis: A Role for Dipeptidyl-Peptidase I and Tissue Inhibitor of Metalloproteinase-3?
Am. J. Respir. Crit. Care Med., December 1, 2007; 176(11): 1098 - 1107.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. L. Martin, T. A. Sheikh, K. J. Leco, J. F. Lewis, and R. A. W. Veldhuizen
Contribution of alveolar macrophages to the response of the TIMP-3 null lung during a septic insult
Am J Physiol Lung Cell Mol Physiol, September 1, 2007; 293(3): L779 - L789.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. C. Willis and Z. Borok
TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease
Am J Physiol Lung Cell Mol Physiol, September 1, 2007; 293(3): L525 - L534.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
D. M. Brass, J. Tomfohr, I. V. Yang, and D. A. Schwartz
Using Mouse Genomics to Understand Idiopathic Interstitial Fibrosis
Proceedings of the ATS, January 1, 2007; 4(1): 92 - 100.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. J. Tan, C. L. Fattman, L. M. Niehouse, J. M. Tobolewski, L. E. Hanford, Q. Li, F. A. Monzon, W. C. Parks, and T. D. Oury
Matrix Metalloproteinases Promote Inflammation and Fibrosis in Asbestos-Induced Lung Injury in Mice
Am. J. Respir. Cell Mol. Biol., September 1, 2006; 35(3): 289 - 297.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. M. Kelly, R. Leigh, S. E. Gilpin, E. Cheng, G. E. M. Martin, K. Radford, G. Cox, and J. Gauldie
Cell-specific Gene Expression in Patients with Usual Interstitial Pneumonia
Am. J. Respir. Crit. Care Med., September 1, 2006; 174(5): 557 - 565.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. Shukla, T. F. Barrett, K. I. Nakayama, K. Nakayama, B. T. Mossman, and K. M. Lounsbury
Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKC{delta}-dependent pathway in murine lung
FASEB J, May 1, 2006; 20(7): 997 - 999.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
P T G Elkington and J S Friedland
Matrix metalloproteinases in destructive pulmonary pathology
Thorax, March 1, 2006; 61(3): 259 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
Y. Asano, H. Ihn, M. Kubo, M. Jinnin, Y. Mimura, R. Ashida, and K. Tamaki
Clinical significance of serum levels of matrix metalloproteinase-13 in patients with systemic sclerosis
Rheumatology, March 1, 2006; 45(3): 303 - 307.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. Fredriksson, X. D. Liu, J. Lundahl, J. Klominek, S. I. Rennard, and C. M. Skold
Red blood cells increase secretion of matrix metalloproteinases from human lung fibroblasts in vitro
Am J Physiol Lung Cell Mol Physiol, February 1, 2006; 290(2): L326 - L333.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
C. Agostini and C. Gurrieri
Chemokine/Cytokine cocktail in idiopathic pulmonary fibrosis.
Proceedings of the ATS, January 1, 2006; 3(4): 357 - 363.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K.-H. Kim, K. Burkhart, P. Chen, C. W. Frevert, J. Randolph-Habecker, R. C. Hackman, P. D. Soloway, and D. K. Madtes
Tissue Inhibitor of Metalloproteinase-1 Deficiency Amplifies Acute Lung Injury in Bleomycin-Exposed Mice
Am. J. Respir. Cell Mol. Biol., September 1, 2005; 33(3): 271 - 279.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Addis-Lieser, J. Kohl, and M. G. Chiaramonte
Opposing Regulatory Roles of Complement Factor 5 in the Development of Bleomycin-Induced Pulmonary Fibrosis
J. Immunol., August 1, 2005; 175(3): 1894 - 1902.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. L. Martin, L. A. McCaig, B. Z. Moyer, M. C. Pape, K. J. Leco, J. F. Lewis, and R. A. W. Veldhuizen
Differential response of TIMP-3 null mice to the lung insults of sepsis, mechanical ventilation, and hyperoxia
Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L244 - L251.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
F. Chua, J. Gauldie, and G. J. Laurent
Pulmonary Fibrosis: Searching for Model Answers
Am. J. Respir. Cell Mol. Biol., July 1, 2005; 33(1): 9 - 13.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Bonniaud, P. J. Margetts, M. Kolb, J. A. Schroeder, A. M. Kapoun, D. Damm, A. Murphy, S. Chakravarty, S. Dugar, L. Higgins, et al.
Progressive Transforming Growth Factor {beta}1-induced Lung Fibrosis Is Blocked by an Orally Active ALK5 Kinase Inhibitor
Am. J. Respir. Crit. Care Med., April 15, 2005; 171(8): 889 - 898.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
H Matsumoto, A Niimi, M Takemura, T Ueda, M Minakuchi, R Tabuena, K Chin, T Mio, Y Ito, S Muro, et al.
Relationship of airway wall thickening to an imbalance between matrix metalloproteinase-9 and its inhibitor in asthma
Thorax, April 1, 2005; 60(4): 277 - 281.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. E. Starr, T. Dan, K. Minhas, P. E. Shewen, and B. L. Coomber
Potential Involvement of Gelatinases and Their Inhibitors in Mannheimia haemolytica Pneumonia in Cattle
Infect. Immun., August 1, 2004; 72(8): 4393 - 4400.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
M R Hill, L Briggs, M M Montano, A Estrada, G J Laurent, M Selman, and A Pardo
Promoter variants in tissue inhibitor of metalloproteinase-3 (TIMP-3) protect against susceptibility in pigeon breeders' disease
Thorax, July 1, 2004; 59(7): 586 - 590.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
X. Liu, R. S. Ostrom, and P. A. Insel
cAMP-elevating agents and adenylyl cyclase overexpression promote an antifibrotic phenotype in pulmonary fibroblasts
Am J Physiol Cell Physiol, May 1, 2004; 286(5): C1089 - C1099.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. L. Martin, B. Z. Moyer, M. C. Pape, B. Starcher, K. J. Leco, and R. A. W. Veldhuizen
Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis
Am J Physiol Lung Cell Mol Physiol, December 1, 2003; 285(6): L1222 - L1232.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
V. Ruiz, R. Ma. Ordonez, J. Berumen, R. Ramirez, B. Uhal, C. Becerril, A. Pardo, and M. Selman
Unbalanced collagenases/TIMP-1 expression and epithelial apoptosis in experimental lung fibrosis
Am J Physiol Lung Cell Mol Physiol, November 1, 2003; 285(5): L1026 - L1036.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Selman
Plunging into the Chaos of the Cytokine/Chemokine Cocktail in Pulmonary Fibrosis: How Many and How Important Are They?
Am. J. Respir. Crit. Care Med., October 1, 2003; 168(7): 730 - 731.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Bonniaud, P. J. Margetts, M. Kolb, T. Haberberger, M. Kelly, J. Robertson, and J. Gauldie
Adenoviral Gene Transfer of Connective Tissue Growth Factor in the Lung Induces Transient Fibrosis
Am. J. Respir. Crit. Care Med., October 1, 2003; 168(7): 770 - 778.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. Cisneros-Lira, M. Gaxiola, C. Ramos, M. Selman, and A. Pardo
Cigarette smoke exposure potentiates bleomycin-induced lung fibrosis in guinea pigs
Am J Physiol Lung Cell Mol Physiol, October 1, 2003; 285(4): L949 - L956.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
X. Zhe, Y. Yang, S. Jakkaraju, and L. Schuger
Tissue Inhibitor of Metalloproteinase-3 Downregulation in Lymphangioleiomyomatosis: Potential Consequence of Abnormal Serum Response Factor Expression
Am. J. Respir. Cell Mol. Biol., April 1, 2003; 28(4): 504 - 511.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. J. Atkinson and R. M. Senior
Matrix Metalloproteinase-9 in Lung Remodeling
Am. J. Respir. Cell Mol. Biol., January 1, 2003; 28(1): 12 - 24.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Kolb, P. Bonniaud, T. Galt, P. J. Sime, M. M. Kelly, P. J. Margetts, and J. Gauldie
Differences in the Fibrogenic Response after Transfer of Active Transforming Growth Factor-{beta}1 Gene to Lungs of "Fibrosis-prone" and "Fibrosis-resistant" Mouse Strains
Am. J. Respir. Cell Mol. Biol., August 1, 2002; 27(2): 141 - 150.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. G. Crystal, P. B. Bitterman, B. Mossman, M. I. Schwarz, D. Sheppard, L. Almasy, H. A. Chapman, S. L. Friedman, T. E. King Jr., L. A. Leinwand, et al.
Future Research Directions in Idiopathic Pulmonary Fibrosis: Summary of a National Heart, Lung, and Blood Institute Working Group
Am. J. Respir. Crit. Care Med., July 15, 2002; 166(2): 236 - 246.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. K. Winkler and J. L. Fowlkes
Metalloproteinase and growth factor interactions: do they play a role in pulmonary fibrosis?
Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L1 - L11.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K. H. Choi, H. B. Lee, M. Y. Jeong, Y. K. Rhee, M. J. Chung, Y. G. Kwak, and Y. C. Lee
The Role of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 in Cryptogenic Organizing Pneumonia*
Chest, May 1, 2002; 121(5): 1478 - 1485.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. Pardo, K. M. Smith, J. Abrams, R. Coffman, M. Bustos, T. K. McClanahan, J. Grein, E. E. Murphy, A. Zlotnik, and M. Selman
CCL18/DC-CK-1/PARC up-regulation in hypersensitivity pneumonitis
J. Leukoc. Biol., October 1, 2001; 70(4): 610 - 616.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
C. Ramos, M. Montaño, J. García-Alvarez, V. Ruiz, B. D. Uhal, M. Selman, and A. Pardo
Fibroblasts from Idiopathic Pulmonary Fibrosis and Normal Lungs Differ in Growth Rate, Apoptosis, and Tissue Inhibitor of Metalloproteinases Expression
Am. J. Respir. Cell Mol. Biol., May 1, 2001; 24(5): 591 - 598.
[Abstract] [Full Text]

Home page
 ANN INTERN MEDHome page
M. Selman, T. E. King Jr., and A. Pardo
Idiopathic Pulmonary Fibrosis: Prevailing and Evolving Hypotheses about Its Pathogenesis and Implications for Therapy
Ann Intern Med, January 16, 2001; 134(2): 136 - 151.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online