| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
-inducible chemokines
1 Division of Pulmonary and Critical Care Medicine and 3 Division of Oncology, Department of Medicine, University of Washington, Seattle 98195; and 2 Fred Hutchinson Cancer Research Center, Seattle, Washington 98109
Proinflammatory responses
generated by T helper type 1 (Th1) cells may contribute significantly
to immune-mediated lung injury. We describe a murine model of Th1
cell-induced lung injury in which adoptive transfer of alloreactive Th1
cells produces pulmonary inflammation characterized by mononuclear cell
vasculitis, alveolitis, and interstitial pneumonitis. To investigate
the link between activation of Th1 cells in the lung and inflammatory
cell recruitment, we characterized cytokine and chemokine mRNA
expression in Th1 cells activated in vitro and in lung tissue after
adoptive transfer of Th1 cells. Activated Th1 cells per se express mRNA
for interferon (IFN)-
and several members of the tumor necrosis
factor family as well as the C-C chemokine receptor-5 ligands regulated
on activation normal T cells expressed and secreted and macrophage
inflammatory protein-1
and -1
. Additional chemokine genes were
induced in the lung after Th1 cell administration, most notably
IFN--inducible protein (IP-10) and monokine induced by IFN-
(MIG). Remarkable increases in IP-10- and MIG-immunoreactive proteins
were present in inflammatory foci lung and identified in macrophages,
endothelium, bronchial epithelium, and alveolar structures. The
findings suggest that IFN--inducible chemokines are an important
mechanism for amplifying inflammation initiated by Th1 cells in the lung.
T helper type 1 and type 2 cells; interferon-; inflammation; in
vivo animal models
This article has been cited by other articles:
|
|
 |
|
  R. Pawliczak, C. Logun, P. Madara, J. Barb, A. F. Suffredini, P. J. Munson, R. L. Danner, and J. H. Shelhamer Influence of IFN-{gamma} on gene expression in normal human bronchial epithelial cells: modulation of IFN-{gamma} effects by dexamethasone Physiol Genomics, September 21, 2005; 23(1): 28 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. C. Hildebrandt, K. M. Olkiewicz, S. Choi, L. A. Corrion, S. G. Clouthier, C. Liu, J. S. Serody, and K. R. Cooke Donor T-cell production of RANTES significantly contributes to the development of idiopathic pneumonia syndrome after allogeneic stem cell transplantation Blood, March 15, 2005; 105(6): 2249 - 2257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kuipers, C. Heirman, D. Hijdra, F. Muskens, M. Willart, S. van Meirvenne, K. Thielemans, H. C. Hoogsteden, and B. N. Lambrecht Dendritic cells retrovirally overexpressing IL-12 induce strong Th1 responses to inhaled antigen in the lung but fail to revert established Th2 sensitization J. Leukoc. Biol., November 1, 2004; 76(5): 1028 - 1038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Hildebrandt, K. M. Olkiewicz, L. A. Corrion, Y. Chang, S. G. Clouthier, C. Liu, and K. R. Cooke Donor-derived TNF-{alpha} regulates pulmonary chemokine expression and the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation Blood, July 15, 2004; 104(2): 586 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Hildebrandt, U. A. Duffner, K. M. Olkiewicz, L. A. Corrion, N. E. Willmarth, D. L. Williams, S. G. Clouthier, C. M. Hogaboam, P. R. Reddy, B. B. Moore, et al. A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation Blood, March 15, 2004; 103(6): 2417 - 2426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Odoms, T. P. Shanley, and H. R. Wong Short-term modulation of interleukin-1{beta} signaling by hyperoxia: uncoupling of I{kappa}B kinase activation and NF-{kappa}B-dependent gene expression Am J Physiol Lung Cell Mol Physiol, March 1, 2004; 286(3): L554 - L562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Fuller, J. L. Flynn, and T. A. Reinhart In Situ Study of Abundant Expression of Proinflammatory Chemokines and Cytokines in Pulmonary Granulomas That Develop in Cynomolgus Macaques Experimentally Infected with Mycobacterium tuberculosis Infect. Immun., December 1, 2003; 71(12): 7023 - 7034. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Kallapur, A. H. Jobe, M. Ikegami, and C. J. Bachurski Increased IP-10 and MIG Expression after Intra-amniotic Endotoxin in Preterm Lamb Lung Am. J. Respir. Crit. Care Med., March 1, 2003; 167(5): 779 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Chung, T. Chitnis, R. J. Panzo, D. L. Kasper, M. H. Sayegh, and A. O. Tzianabos CD4+ T Cells Regulate Surgical and Postinfectious Adhesion Formation J. Exp. Med., June 3, 2002; 195(11): 1471 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. P. Jones, L. M. Hodge, K. Fujihashi, H. Kiyono, J. R. McGhee, and J. W. Simecka The Pulmonary Environment Promotes Th2 Cell Responses After Nasal-Pulmonary Immunization with Antigen Alone, but Th1 Responses Are Induced During Instances of Intense Immune Stimulation J. Immunol., October 15, 2001; 167(8): 4518 - 4526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. PRINCE, P. H. KARP, T. O. MONINGER, and M. J. WELSH KGF alters gene expression in human airway epithelia: potential regulation of the inflammatory response Physiol Genomics, July 17, 2001; 6(2): 81 - 89. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
