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Pulmonary and Critical Care Division, Department of Medicine, New England Medical Center/Tupper Research Institute, Tufts University School of Medicine, Boston, Massachusetts 02111
Reactive oxygen species (ROS) are generated as by-products of cellular metabolism, primarily in the mitochondria. When cellular production of ROS overwhelms its antioxidant capacity, damage to cellular macromolecules such as lipids, protein, and DNA may ensue. Such a state of "oxidative stress" is thought to contribute to the pathogenesis of a number of human diseases including those of the lung. Recent studies have also implicated ROS that are generated by specialized plasma membrane oxidases in normal physiological signaling by growth factors and cytokines. In this review, we examine the evidence for ligand-induced generation of ROS, its cellular sources, and the signaling pathways that are activated. Emerging concepts on the mechanisms of signal transduction by ROS that involve alterations in cellular redox state and oxidative modifications of proteins are also discussed.
redox signaling; growth factors; cytokines; oxidation-reduction; free radicals
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W.C.L. Ford Regulation of sperm function by reactive oxygen species Hum. Reprod. Update, September 1, 2004; 10(5): 387 - 399. [Abstract] [Full Text] [PDF] |
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H. J. Forman, J. M. Fukuto, and M. Torres Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers Am J Physiol Cell Physiol, August 1, 2004; 287(2): C246 - C256. [Abstract] [Full Text] [PDF] |
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Z. Zhang, K. Rhinehart, W. Kwon, E. Weinman, and T. L. Pallone ANG II signaling in vasa recta pericytes by PKC and reactive oxygen species Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H773 - H781. [Abstract] [Full Text] [PDF] |
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L. Zeng, H. Xu, T.-L. Chew, R. Chisholm, M. M. Sadeghi, Y. S. Kanwar, and F. R. Danesh Simvastatin Modulates Angiotensin II Signaling Pathway by Preventing Rac1-Mediated Upregulation of p27 J. Am. Soc. Nephrol., July 1, 2004; 15(7): 1711 - 1720. [Abstract] [Full Text] [PDF] |
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H. Han, H. Long, H. Wang, J. Wang, Y. Zhang, and Z. Wang Progressive apoptotic cell death triggered by transient oxidative insult in H9c2 rat ventricular cells: a novel pattern of apoptosis and the mechanisms Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2169 - H2182. [Abstract] [Full Text] [PDF] |
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W. Cao, M. D. Vrees, M. T. Kirber, C. Fiocchi, and V. E. Pricolo Hydrogen peroxide contributes to motor dysfunction in ulcerative colitis Am J Physiol Gastrointest Liver Physiol, May 1, 2004; 286(5): G833 - G843. [Abstract] [Full Text] [PDF] |
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C. S. Powell, M. M. Wright, and R. M. Jackson p38mapk and MEK1/2 inhibition contribute to cellular oxidant injury after hypoxia Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L826 - L833. [Abstract] [Full Text] [PDF] |
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H. Xu, G. D. Fink, and J. J. Galligan Tempol Lowers Blood Pressure and Sympathetic Nerve Activity But Not Vascular O2- in DOCA-Salt Rats Hypertension, February 1, 2004; 43(2): 329 - 334. [Abstract] [Full Text] [PDF] |
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N. Thengchaisri and L. Kuo Hydrogen peroxide induces endothelium-dependent and -independent coronary arteriolar dilation: role of cyclooxygenase and potassium channels Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2255 - H2263. [Abstract] [Full Text] [PDF] |
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Y.-Q. Zhu, Y. Lu, and X.-D. Tan Monochloramine induces reorganization of nuclear speckles and phosphorylation of SRp30 in human colonic epithelial cells: role of protein kinase C Am J Physiol Cell Physiol, November 1, 2003; 285(5): C1294 - C1303. [Abstract] [Full Text] [PDF] |
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G. Bloomfield and C. Pears Superoxide signalling required for multicellular development of Dictyostelium J. Cell Sci., August 15, 2003; 116(16): 3387 - 3397. [Abstract] [Full Text] [PDF] |
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B. Lassegue and R. E. Clempus Vascular NAD(P)H oxidases: specific features, expression, and regulation Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R277 - R297. [Abstract] [Full Text] [PDF] |
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T. Chabrashvili, C. Kitiyakara, J. Blau, A. Karber, S. Aslam, W. J. Welch, and C. S. Wilcox Effects of ANG II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expression Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2003; 285(1): R117 - R124. [Abstract] [Full Text] [PDF] |
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X. Wang, S. A. Phelan, K. Forsman-Semb, E. F. Taylor, C. Petros, A. Brown, C. P. Lerner, and B. Paigen Mice with Targeted Mutation of Peroxiredoxin 6 Develop Normally but Are Susceptible to Oxidative Stress J. Biol. Chem., June 27, 2003; 278(27): 25179 - 25190. [Abstract] [Full Text] [PDF] |
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V. L. Kinnula and J. D. Crapo Superoxide Dismutases in the Lung and Human Lung Diseases Am. J. Respir. Crit. Care Med., June 15, 2003; 167(12): 1600 - 1619. [Abstract] [Full Text] [PDF] |
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Y. Zhang, T. Tazzeo, S. Hirota, and L. J. Janssen Vasodilatory and Electrophysiological Actions of 8-iso-Prostaglandin E2 in Porcine Coronary Artery J. Pharmacol. Exp. Ther., June 1, 2003; 305(3): 1054 - 1060. [Abstract] [Full Text] [PDF] |
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X.-L. Chen, Q. Zhang, R. Zhao, X. Ding, P. E. Tummala, and R. M. Medford Rac1 and Superoxide Are Required for the Expression of Cell Adhesion Molecules Induced by Tumor Necrosis Factor-alpha in Endothelial Cells J. Pharmacol. Exp. Ther., May 1, 2003; 305(2): 573 - 580. [Abstract] [Full Text] [PDF] |
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V. J. Thannickal The paradox of reactive oxygen species: injury, signaling, or both? Am J Physiol Lung Cell Mol Physiol, January 1, 2003; 284(1): L24 - L25. [Full Text] [PDF] |
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N. L. Parinandi, M. A. Kleinberg, P. V. Usatyuk, R. J. Cummings, A. Pennathur, A. J. Cardounel, J. L. Zweier, J. G. N. Garcia, and V. Natarajan Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells Am J Physiol Lung Cell Mol Physiol, January 1, 2003; 284(1): L26 - L38. [Abstract] [Full Text] [PDF] |
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G. Lebuffe, P. T. Schumacker, Z.-H. Shao, T. Anderson, H. Iwase, and T. L. Vanden Hoek ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H299 - H308. [Abstract] [Full Text] [PDF] |
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