INVITED REVIEW
Reactive oxygen species in cell signaling

Pulmonary and Critical Care Division, Department of Medicine, New England Medical Center/Tupper Research Institute, Tufts University School of Medicine, Boston, Massachusetts 02111

redox signaling; growth factors; cytokines; oxidation-reduction; free radicals

This article has been cited by other articles:

				I. H. Lambert, T. K. Klausen, A. Bergdahl, C. Hougaard, and E. K. Hoffmann ROS activate KCl cotransport in nonadherent Ehrlich ascites cells but K+ and Cl- channels in adherent Ehrlich Lettre and NIH3T3 cells Am J Physiol Cell Physiol, July 1, 2009; 297(1): C198 - C206. [Abstract] [Full Text] [PDF]

				M. Madesh, W.-X. Zong, B. J. Hawkins, S. Ramasamy, T. Venkatachalam, P. Mukhopadhyay, P. J. Doonan, K. M. Irrinki, M. Rajesh, P. Pacher, et al. Execution of Superoxide-Induced Cell Death by the Proapoptotic Bcl-2-Related Proteins Bid and Bak Mol. Cell. Biol., June 1, 2009; 29(11): 3099 - 3112. [Abstract] [Full Text] [PDF]

				V. J. Thannickal Oxygen in the Evolution of Complex Life and the Price We Pay Am. J. Respir. Cell Mol. Biol., May 1, 2009; 40(5): 507 - 510. [Full Text] [PDF]

				X. Zhou, K. Wen, D. Yuan, L. Ai, and P. He Calcium influx-dependent differential actions of superoxide and hydrogen peroxide on microvessel permeability Am J Physiol Heart Circ Physiol, April 1, 2009; 296(4): H1096 - H1107. [Abstract] [Full Text] [PDF]

				M. C. Tal, M. Sasai, H. K. Lee, B. Yordy, G. S. Shadel, and A. Iwasaki Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling PNAS, February 24, 2009; 106(8): 2770 - 2775. [Abstract] [Full Text] [PDF]

				E. K. Hoffmann, I. H. Lambert, and S. F. Pedersen Physiology of Cell Volume Regulation in Vertebrates Physiol Rev, January 1, 2009; 89(1): 193 - 277. [Abstract] [Full Text] [PDF]

				K. Mori, E. Hirao, Y. Toya, Y. Oshima, F. Ishikawa, K. Nose, and M. Shibanuma Competitive Nuclear Export of Cyclin D1 and Hic-5 Regulates Anchorage Dependence of Cell Growth and Survival Mol. Biol. Cell, January 1, 2009; 20(1): 218 - 232. [Abstract] [Full Text] [PDF]

				C. D. Fike, J. C. Slaughter, M. R. Kaplowitz, Y. Zhang, and J. L. Aschner Reactive oxygen species from NADPH oxidase contribute to altered pulmonary vascular responses in piglets with chronic hypoxia-induced pulmonary hypertension Am J Physiol Lung Cell Mol Physiol, November 1, 2008; 295(5): L881 - L888. [Abstract] [Full Text] [PDF]

				J. C. O'Connor, D. M. Wallace, C. J. O'Brien, and T. G. Cotter A Novel Antioxidant Function for the Tumor-Suppressor Gene p53 in the Retinal Ganglion Cell Invest. Ophthalmol. Vis. Sci., October 1, 2008; 49(10): 4237 - 4244. [Abstract] [Full Text] [PDF]

				T. Yu, S.-S. Sheu, J. L. Robotham, and Y. Yoon Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species Cardiovasc Res, July 15, 2008; 79(2): 341 - 351. [Abstract] [Full Text] [PDF]

				H. S. Kim, P. A. Loughran, J. Rao, T. R. Billiar, and B. S. Zuckerbraun Carbon monoxide activates NF-{kappa}B via ROS generation and Akt pathways to protect against cell death of hepatocytes Am J Physiol Gastrointest Liver Physiol, July 1, 2008; 295(1): G146 - G152. [Abstract] [Full Text] [PDF]

				R. Linden, V. R. Martins, M. A. M. Prado, M. Cammarota, I. Izquierdo, and R. R. Brentani Physiology of the Prion Protein Physiol Rev, April 1, 2008; 88(2): 673 - 728. [Abstract] [Full Text] [PDF]

				N. C. Lockhart and S. V. Brooks Neutrophil accumulation following passive stretches contributes to adaptations that reduce contraction-induced skeletal muscle injury in mice J Appl Physiol, April 1, 2008; 104(4): 1109 - 1115. [Abstract] [Full Text] [PDF]

				C. Werth, D. Stuhlmann, B. Cat, H. Steinbrenner, L. Alili, H. Sies, and P. Brenneisen Stromal resistance of fibroblasts against oxidative damage: involvement of tumor cell-secreted platelet-derived growth factor (PDGF) and phosphoinositide 3-kinase (PI3K) activation Carcinogenesis, February 1, 2008; 29(2): 404 - 410. [Abstract] [Full Text] [PDF]

				S. L. Wakefield, M. Lane, S. J. Schulz, M. L. Hebart, J. G. Thompson, and M. Mitchell Maternal supply of omega-3 polyunsaturated fatty acids alter mechanisms involved in oocyte and early embryo development in the mouse Am J Physiol Endocrinol Metab, February 1, 2008; 294(2): E425 - E434. [Abstract] [Full Text] [PDF]

				K. Unfried, U. Sydlik, K. Bierhals, A. Weissenberg, and J. Abel Carbon nanoparticle-induced lung epithelial cell proliferation is mediated by receptor-dependent Akt activation Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L358 - L367. [Abstract] [Full Text] [PDF]

				T. Ishizuka, J. Cheng, H. Singh, M. D. Vitto, V. L. Manthati, J. R. Falck, and M. Laniado-Schwartzman 20-Hydroxyeicosatetraenoic Acid Stimulates Nuclear Factor-{kappa}B Activation and the Production of Inflammatory Cytokines in Human Endothelial Cells J. Pharmacol. Exp. Ther., January 1, 2008; 324(1): 103 - 110. [Abstract] [Full Text] [PDF]

				G. B. Waypa and P. T. Schumacker Oxygen sensing in hypoxic pulmonary vasoconstriction: using new tools to answer an age-old question Exp Physiol, January 1, 2008; 93(1): 133 - 138. [Abstract] [Full Text] [PDF]

				M. J. Coffey, C. H. Serezani, S. M. Phare, N. Flamand, and M. Peters-Golden NADPH oxidase deficiency results in reduced alveolar macrophage 5-lipoxygenase expression and decreased leukotriene synthesis J. Leukoc. Biol., December 1, 2007; 82(6): 1585 - 1591. [Abstract] [Full Text] [PDF]

				G. Ding, A. Zhang, S. Huang, X. Pan, G. Zhen, R. Chen, and T. Yang ANG II induces c-Jun NH2-terminal kinase activation and proliferation of human mesangial cells via redox-sensitive transactivation of the EGFR Am J Physiol Renal Physiol, December 1, 2007; 293(6): F1889 - F1897. [Abstract] [Full Text] [PDF]

				L. Geraets, H. J. J. Moonen, K. Brauers, E. F. M. Wouters, A. Bast, and G. J. Hageman Dietary Flavones and Flavonoles Are Inhibitors of Poly(ADP-ribose)polymerase-1 in Pulmonary Epithelial Cells J. Nutr., October 1, 2007; 137(10): 2190 - 2195. [Abstract] [Full Text] [PDF]

				W. Sangrar, Y. Gao, M. Scott, P. Truesdell, and P. A. Greer Fer-Mediated Cortactin Phosphorylation Is Associated with Efficient Fibroblast Migration and Is Dependent on Reactive Oxygen Species Generation during Integrin-Mediated Cell Adhesion Mol. Cell. Biol., September 1, 2007; 27(17): 6140 - 6152. [Abstract] [Full Text] [PDF]

				W. J. H. Koopman, S. Verkaart, H. J. Visch, S. van Emst-de Vries, L. G. J. Nijtmans, J. A. M. Smeitink, and P. H. G. M. Willems Human NADH:ubiquinone oxidoreductase deficiency: radical changes in mitochondrial morphology? Am J Physiol Cell Physiol, July 1, 2007; 293(1): C22 - C29. [Abstract] [Full Text] [PDF]

				B. Ding, S. G. Chi, S. H. Kim, S. Kang, J. H. Cho, D. S. Kim, and N. H. Cho Role of p53 in antioxidant defense of HPV-positive cervical carcinoma cells following H2O2 exposure J. Cell Sci., July 1, 2007; 120(13): 2284 - 2294. [Abstract] [Full Text] [PDF]

				I. H. Lambert Activation and inactivation of the volume-sensitive taurine leak pathway in NIH3T3 fibroblasts and Ehrlich Lettre ascites cells Am J Physiol Cell Physiol, July 1, 2007; 293(1): C390 - C400. [Abstract] [Full Text] [PDF]

				R. Jagadeeswaran, S. Jagadeeswaran, V. P. Bindokas, and R. Salgia Activation of HGF/c-Met pathway contributes to the reactive oxygen species generation and motility of small cell lung cancer cells Am J Physiol Lung Cell Mol Physiol, June 1, 2007; 292(6): L1488 - L1494. [Abstract] [Full Text] [PDF]

				B. J. Hawkins, M. Madesh, C. J. Kirkpatrick, and A. B. Fisher Superoxide Flux in Endothelial Cells via the Chloride Channel-3 Mediates Intracellular Signaling Mol. Biol. Cell, June 1, 2007; 18(6): 2002 - 2012. [Abstract] [Full Text] [PDF]

				R. Medeiros, R. D. S. Prediger, G. F. Passos, P. Pandolfo, F. S. Duarte, J. L. Franco, A. L. Dafre, G. Di Giunta, C. P. Figueiredo, R. N. Takahashi, et al. Connecting TNF-{alpha} Signaling Pathways to iNOS Expression in a Mouse Model of Alzheimer's Disease: Relevance for the Behavioral and Synaptic Deficits Induced by Amyloid {beta} Protein J. Neurosci., May 16, 2007; 27(20): 5394 - 5404. [Abstract] [Full Text] [PDF]

				Y. Kokusho, T. Komaru, S. Takeda, K. Takahashi, R. Koshida, K. Shirato, and H. Shimokawa Hydrogen Peroxide Derived From Beating Heart Mediates Coronary Microvascular Dilation During Tachycardia Arterioscler. Thromb. Vasc. Biol., May 1, 2007; 27(5): 1057 - 1063. [Abstract] [Full Text] [PDF]

				L. B. Michaud, J. P. Karpinski, K. L. Jones, and J. Espirito Dietary supplements in patients with cancer: Risks and key concepts, part 1 Am. J. Health Syst. Pharm., February 15, 2007; 64(4): 369 - 381. [Abstract] [Full Text] [PDF]

				C. Yu, B. B. Friday, J.-P. Lai, A. McCollum, P. Atadja, L. R. Roberts, and A. A. Adjei Abrogation of MAPK and Akt Signaling by AEE788 Synergistically Potentiates Histone Deacetylase Inhibitor-Induced Apoptosis through Reactive Oxygen Species Generation Clin. Cancer Res., February 15, 2007; 13(4): 1140 - 1148. [Abstract] [Full Text] [PDF]

				J. P. Fruehauf and F. L. Meyskens Jr. Reactive Oxygen Species: A Breath of Life or Death? Clin. Cancer Res., February 1, 2007; 13(3): 789 - 794. [Abstract] [Full Text] [PDF]

				K. Bedard and K.-H. Krause The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology Physiol Rev, January 1, 2007; 87(1): 245 - 313. [Abstract] [Full Text] [PDF]

				M. S Parihar and G. J. Brewer Mitoenergetic failure in Alzheimer disease Am J Physiol Cell Physiol, January 1, 2007; 292(1): C8 - C23. [Abstract] [Full Text] [PDF]

				S. Kurtz, K. P. McKinnon, M. S. Runge, J. P.-Y. Ting, and M. Braunstein The SecA2 Secretion Factor of Mycobacterium tuberculosis Promotes Growth in Macrophages and Inhibits the Host Immune Response Infect. Immun., December 1, 2006; 74(12): 6855 - 6864. [Abstract] [Full Text] [PDF]

				C. D. Georgiou, N. Patsoukis, I. Papapostolou, and G. Zervoudakis Sclerotial metamorphosis in filamentous fungi is induced by oxidative stress Integr. Comp. Biol., December 1, 2006; 46(6): 691 - 712. [Abstract] [Full Text] [PDF]

				J. D. Joo, M. Kim, V. D. D'Agati, and H. T. Lee Ischemic Preconditioning Provides Both Acute and Delayed Protection against Renal Ischemia and Reperfusion Injury in Mice J. Am. Soc. Nephrol., November 1, 2006; 17(11): 3115 - 3123. [Abstract] [Full Text] [PDF]

				G. B. Waypa, R. Guzy, P. T. Mungai, M. M. Mack, J. D. Marks, M. W. Roe, and P. T. Schumacker Increases in Mitochondrial Reactive Oxygen Species Trigger Hypoxia-Induced Calcium Responses in Pulmonary Artery Smooth Muscle Cells Circ. Res., October 27, 2006; 99(9): 970 - 978. [Abstract] [Full Text] [PDF]

				N. Thengchaisri, T. W. Hein, W. Wang, X. Xu, Z. Li, T. W. Fossum, and L. Kuo Upregulation of Arginase by H2O2 Impairs Endothelium-Dependent Nitric Oxide-Mediated Dilation of Coronary Arterioles Arterioscler. Thromb. Vasc. Biol., September 1, 2006; 26(9): 2035 - 2042. [Abstract] [Full Text] [PDF]

				R. M. McAdams, S. B. Mustafa, J. S. Shenberger, P. S. Dixon, B. M. Henson, and R. J. DiGeronimo Cyclic stretch attenuates effects of hyperoxia on cell proliferation and viability in human alveolar epithelial cells Am J Physiol Lung Cell Mol Physiol, August 1, 2006; 291(2): L166 - L174. [Abstract] [Full Text] [PDF]

				I. Rahman and I. M. Adcock Oxidative stress and redox regulation of lung inflammation in COPD. Eur. Respir. J., July 1, 2006; 28(1): 219 - 242. [Abstract] [Full Text] [PDF]

				B. Cat, D. Stuhlmann, H. Steinbrenner, L. Alili, O. Holtkotter, H. Sies, and P. Brenneisen Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species J. Cell Sci., July 1, 2006; 119(13): 2727 - 2738. [Abstract] [Full Text] [PDF]

				V. Thakur, M. T. Pritchard, M. R. McMullen, Q. Wang, and L. E. Nagy Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-{alpha} production J. Leukoc. Biol., June 1, 2006; 79(6): 1348 - 1356. [Abstract] [Full Text] [PDF]

				I. Rubio-Gayosso, S. H. Platts, and B. R. Duling Reactive oxygen species mediate modification of glycocalyx during ischemia-reperfusion injury Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2247 - H2256. [Abstract] [Full Text] [PDF]

				X. Wang, M. Tong, S. Chinta, J. U. Raj, and Y. Gao Hypoxia-induced reactive oxygen species downregulate ETB receptor-mediated contraction of rat pulmonary arteries Am J Physiol Lung Cell Mol Physiol, March 1, 2006; 290(3): L570 - L578. [Abstract] [Full Text] [PDF]

				L. Xia, H. Wang, H. J. Goldberg, S. Munk, I. G. Fantus, and C. I. Whiteside Mesangial cell NADPH oxidase upregulation in high glucose is protein kinase C dependent and required for collagen IV expression Am J Physiol Renal Physiol, February 1, 2006; 290(2): F345 - F356. [Abstract] [Full Text] [PDF]

				A. Cebrian, P. D. Pharoah, S. Ahmed, P. L. Smith, C. Luccarini, R. Luben, K. Redman, H. Munday, D. F. Easton, A. M. Dunning, et al. Tagging Single-Nucleotide Polymorphisms in Antioxidant Defense Enzymes and Susceptibility to Breast Cancer Cancer Res., January 15, 2006; 66(2): 1225 - 1233. [Abstract] [Full Text] [PDF]

				J.-G. Wang, S. A. Mahmud, J. A. Thompson, J.-G. Geng, N. S. Key, and A. Slungaard The principal eosinophil peroxidase product, HOSCN, is a uniquely potent phagocyte oxidant inducer of endothelial cell tissue factor activity: a potential mechanism for thrombosis in eosinophilic inflammatory states Blood, January 15, 2006; 107(2): 558 - 565. [Abstract] [Full Text] [PDF]

				G. A. Finlay, V. J. Thannickal, B. L. Fanburg, and D. J. Kwiatkowski Platelet-Derived Growth Factor-Induced p42/44 Mitogen-Activated Protein Kinase Activation and Cellular Growth Is Mediated by Reactive Oxygen Species in the Absence of TSC2/Tuberin Cancer Res., December 1, 2005; 65(23): 10881 - 10890. [Abstract] [Full Text] [PDF]

				S. Yang, K. Irani, S. E. Heffron, F. Jurnak, and F. L. Meyskens Jr. Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor Mol. Cancer Ther., December 1, 2005; 4(12): 1923 - 1935. [Abstract] [Full Text] [PDF]

				M. Edderkaoui, P. Hong, E. C. Vaquero, J. K. Lee, L. Fischer, H. Friess, M. W. Buchler, M. M. Lerch, S. J. Pandol, and A. S. Gukovskaya Extracellular matrix stimulates reactive oxygen species production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH oxidase Am J Physiol Gastrointest Liver Physiol, December 1, 2005; 289(6): G1137 - G1147. [Abstract] [Full Text] [PDF]

				P. V. Usatyuk and V. Natarajan Regulation of reactive oxygen species-induced endothelial cell-cell and cell-matrix contacts by focal adhesion kinase and adherens junction proteins Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L999 - L1010. [Abstract] [Full Text] [PDF]

				Y.-J. Surh, J. K. Kundu, H.-K. Na, and J.-S. Lee Redox-Sensitive Transcription Factors as Prime Targets for Chemoprevention with Anti-Inflammatory and Antioxidative Phytochemicals J. Nutr., December 1, 2005; 135(12): 2993S - 3001S. [Abstract] [Full Text] [PDF]

				C. A. Owen Proteinases and Oxidants as Targets in the Treatment of Chronic Obstructive Pulmonary Disease Proceedings of the ATS, November 1, 2005; 2(4): 373 - 385. [Abstract] [Full Text] [PDF]

				L. Cheng, W. Cao, C. Fiocchi, J. Behar, P. Biancani, and K. M. Harnett In vitro model of acute esophagitis in the cat Am J Physiol Gastrointest Liver Physiol, November 1, 2005; 289(5): G860 - G869. [Abstract] [Full Text] [PDF]

				P.-L. Liu, Y.-L. Chen, Y.-H. Chen, S.-J. Lin, and Y. R. Kou Wood smoke extract induces oxidative stress-mediated caspase-independent apoptosis in human lung endothelial cells: role of AIF and EndoG Am J Physiol Lung Cell Mol Physiol, November 1, 2005; 289(5): L739 - L749. [Abstract] [Full Text] [PDF]

				M. S. Attene-Ramos, K. Kitiphongspattana, K. Ishii-Schrade, and H. R. Gaskins Temporal changes of multiple redox couples from proliferation to growth arrest in IEC-6 intestinal epithelial cells Am J Physiol Cell Physiol, November 1, 2005; 289(5): C1220 - C1228. [Abstract] [Full Text] [PDF]

				C. H. C. Serezani, D. M. Aronoff, S. Jancar, and M. Peters-Golden Leukotriene B4 mediates p47phox phosphorylation and membrane translocation in polyunsaturated fatty acid-stimulated neutrophils J. Leukoc. Biol., October 1, 2005; 78(4): 976 - 984. [Abstract] [Full Text] [PDF]

				A. V. Cybulsky, R. J. Quigg, and D. J. Salant Experimental membranous nephropathy redux Am J Physiol Renal Physiol, October 1, 2005; 289(4): F660 - F671. [Abstract] [Full Text] [PDF]

				D.-b. Chen, S.-m. Li, X.-X. Qian, C. Moon, and J. Zheng Tyrosine Phosphorylation of Caveolin 1 by Oxidative Stress Is Reversible and Dependent on the c-src Tyrosine Kinase but Not Mitogen-Activated Protein Kinase Pathways in Placental Artery Endothelial Cells Biol Reprod, October 1, 2005; 73(4): 761 - 772. [Abstract] [Full Text] [PDF]

				C. Berthet, K. Raj, P. Saudan, and P. Beard How adeno-associated virus Rep78 protein arrests cells completely in S phase PNAS, September 20, 2005; 102(38): 13634 - 13639. [Abstract] [Full Text] [PDF]

				V. Fernandez, G. Tapia, P. Varela, I. Castillo, C. Mora, F. Moya, M. Orellana, and L. A Videla Redox up-regulated expression of rat liver manganese superoxide dismutase and Bcl-2 by thyroid hormone is associated with inhibitor of {kappa}B-{alpha} phosphorylation and nuclear factor-{kappa}B activation J. Endocrinol., September 1, 2005; 186(3): 539 - 547. [Abstract] [Full Text] [PDF]

				P. R. Chess, M. A. O'Reilly, F. Sachs, and J. N. Finkelstein Reactive oxidant and p42/44 MAP kinase signaling is necessary for mechanical strain-induced proliferation in pulmonary epithelial cells J Appl Physiol, September 1, 2005; 99(3): 1226 - 1232. [Abstract] [Full Text] [PDF]

				L. Wang, S. Clutter, J. Benincosa, J. Fortney, and L. F. Gibson Activation of Transforming Growth Factor-{beta}1/p38/Smad3 Signaling in Stromal Cells Requires Reactive Oxygen Species-Mediated MMP-2 Activity During Bone Marrow Damage Stem Cells, September 1, 2005; 23(8): 1122 - 1134. [Abstract] [Full Text] [PDF]

				A. M. Condliffe, K. Davidson, K. E. Anderson, C. D. Ellson, T. Crabbe, K. Okkenhaug, B. Vanhaesebroeck, M. Turner, L. Webb, M. P. Wymann, et al. Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils Blood, August 15, 2005; 106(4): 1432 - 1440. [Abstract] [Full Text] [PDF]

				A. Pines, L. Perrone, N. Bivi, M. Romanello, G. Damante, M. Gulisano, M. R. Kelley, F. Quadrifoglio, and G. Tell Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP Nucleic Acids Res., August 2, 2005; 33(14): 4379 - 4394. [Abstract] [Full Text] [PDF]

				C. O'Flaherty, E. de Lamirande, and C. Gagnon Reactive Oxygen Species and Protein Kinases Modulate the Level of Phospho-MEK-Like Proteins During Human Sperm Capacitation Biol Reprod, July 1, 2005; 73(1): 94 - 105. [Abstract] [Full Text] [PDF]

				W. Cao, K. M. Harnett, L. Cheng, M. T. Kirber, J. Behar, and P. Biancani H2O2: a mediator of esophagitis-induced damage to calcium-release mechanisms in cat lower esophageal sphincter Am J Physiol Gastrointest Liver Physiol, June 1, 2005; 288(6): G1170 - G1178. [Abstract] [Full Text] [PDF]

				J. M. Cook-Mills and T. L. Deem Active participation of endothelial cells in inflammation J. Leukoc. Biol., April 1, 2005; 77(4): 487 - 495. [Abstract] [Full Text] [PDF]

				L. Cheng, W. Cao, J. Behar, P. Biancani, and K. M. Harnett Inflammation induced changes in arachidonic acid metabolism in cat LES circular muscle Am J Physiol Gastrointest Liver Physiol, April 1, 2005; 288(4): G787 - G797. [Abstract] [Full Text] [PDF]

				M. Ruchko, O. Gorodnya, S. P. LeDoux, M. F. Alexeyev, A.-B. Al-Mehdi, and M. N. Gillespie Mitochondrial DNA damage triggers mitochondrial dysfunction and apoptosis in oxidant-challenged lung endothelial cells Am J Physiol Lung Cell Mol Physiol, March 1, 2005; 288(3): L530 - L535. [Abstract] [Full Text] [PDF]

				L. Zhu, V. Castranova, and P. He fMLP-stimulated neutrophils increase endothelial [Ca2+]i and microvessel permeability in the absence of adhesion: role of reactive oxygen species Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1331 - H1338. [Abstract] [Full Text] [PDF]

				P. Cettour-Rose, T. X. K. Nguyen, L. Serrander, M.-T. Kaufmann, J.-M. Dayer, D. Burger, and P. Roux-Lombard T cell contact-mediated activation of respiratory burst in human polymorphonuclear leukocytes is inhibited by high-density lipoproteins and involves CD18 J. Leukoc. Biol., January 1, 2005; 77(1): 52 - 58. [Abstract] [Full Text] [PDF]

				Z. Zhang, K. Rhinehart, G. Solis, J. Pittner, W. Lee-Kwon, W. J. Welch, C. S. Wilcox, and T. L. Pallone Chronic ANG II infusion increases NO generation by rat descending vasa recta Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H29 - H36. [Abstract] [Full Text] [PDF]

				J.-J. Ventura, P. Cogswell, R. A. Flavell, A. S. Baldwin Jr., and R. J. Davis JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species Genes & Dev., December 1, 2004; 18(23): 2905 - 2915. [Abstract] [Full Text] [PDF]

				K. Mori, M. Shibanuma, and K. Nose Invasive Potential Induced under Long-Term Oxidative Stress in Mammary Epithelial Cells Cancer Res., October 15, 2004; 64(20): 7464 - 7472. [Abstract] [Full Text] [PDF]

				S. Chatterjee and A. B. Fisher ROS to the rescue Am J Physiol Lung Cell Mol Physiol, October 1, 2004; 287(4): L704 - L705. [Full Text] [PDF]

				R. P. Bowler, M. Nicks, K. Tran, G. Tanner, L.-Y. Chang, S. K. Young, and G. S. Worthen Extracellular Superoxide Dismutase Attenuates Lipopolysaccharide-Induced Neutrophilic Inflammation Am. J. Respir. Cell Mol. Biol., October 1, 2004; 31(4): 432 - 439. [Abstract] [Full Text] [PDF]

				Y. Liu, Y. J. Suzuki, R. M. Day, and B. L. Fanburg Rho Kinase-Induced Nuclear Translocation of ERK1/ERK2 in Smooth Muscle Cell Mitogenesis Caused by Serotonin Circ. Res., September 17, 2004; 95(6): 579 - 586. [Abstract] [Full Text] [PDF]

				W.C.L. Ford Regulation of sperm function by reactive oxygen species Hum. Reprod. Update, September 1, 2004; 10(5): 387 - 399. [Abstract] [Full Text] [PDF]

				H. J. Forman, J. M. Fukuto, and M. Torres Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers Am J Physiol Cell Physiol, August 1, 2004; 287(2): C246 - C256. [Abstract] [Full Text] [PDF]

				Z. Zhang, K. Rhinehart, W. Kwon, E. Weinman, and T. L. Pallone ANG II signaling in vasa recta pericytes by PKC and reactive oxygen species Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H773 - H781. [Abstract] [Full Text] [PDF]

				L. Zeng, H. Xu, T.-L. Chew, R. Chisholm, M. M. Sadeghi, Y. S. Kanwar, and F. R. Danesh Simvastatin Modulates Angiotensin II Signaling Pathway by Preventing Rac1-Mediated Upregulation of p27 J. Am. Soc. Nephrol., July 1, 2004; 15(7): 1711 - 1720. [Abstract] [Full Text] [PDF]

				H. Han, H. Long, H. Wang, J. Wang, Y. Zhang, and Z. Wang Progressive apoptotic cell death triggered by transient oxidative insult in H9c2 rat ventricular cells: a novel pattern of apoptosis and the mechanisms Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2169 - H2182. [Abstract] [Full Text] [PDF]

				W. Cao, M. D. Vrees, M. T. Kirber, C. Fiocchi, and V. E. Pricolo Hydrogen peroxide contributes to motor dysfunction in ulcerative colitis Am J Physiol Gastrointest Liver Physiol, May 1, 2004; 286(5): G833 - G843. [Abstract] [Full Text] [PDF]

				C. S. Powell, M. M. Wright, and R. M. Jackson p38mapk and MEK1/2 inhibition contribute to cellular oxidant injury after hypoxia Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L826 - L833. [Abstract] [Full Text] [PDF]

				H. Xu, G. D. Fink, and J. J. Galligan Tempol Lowers Blood Pressure and Sympathetic Nerve Activity But Not Vascular O2- in DOCA-Salt Rats Hypertension, February 1, 2004; 43(2): 329 - 334. [Abstract] [Full Text] [PDF]

				N. Thengchaisri and L. Kuo Hydrogen peroxide induces endothelium-dependent and -independent coronary arteriolar dilation: role of cyclooxygenase and potassium channels Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2255 - H2263. [Abstract] [Full Text] [PDF]

				Y.-Q. Zhu, Y. Lu, and X.-D. Tan Monochloramine induces reorganization of nuclear speckles and phosphorylation of SRp30 in human colonic epithelial cells: role of protein kinase C Am J Physiol Cell Physiol, November 1, 2003; 285(5): C1294 - C1303. [Abstract] [Full Text] [PDF]

				G. Bloomfield and C. Pears Superoxide signalling required for multicellular development of Dictyostelium J. Cell Sci., August 15, 2003; 116(16): 3387 - 3397. [Abstract] [Full Text] [PDF]

				B. Lassegue and R. E. Clempus Vascular NAD(P)H oxidases: specific features, expression, and regulation Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R277 - R297. [Abstract] [Full Text] [PDF]

				T. Chabrashvili, C. Kitiyakara, J. Blau, A. Karber, S. Aslam, W. J. Welch, and C. S. Wilcox Effects of ANG II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expression Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2003; 285(1): R117 - R124. [Abstract] [Full Text] [PDF]

				X. Wang, S. A. Phelan, K. Forsman-Semb, E. F. Taylor, C. Petros, A. Brown, C. P. Lerner, and B. Paigen Mice with Targeted Mutation of Peroxiredoxin 6 Develop Normally but Are Susceptible to Oxidative Stress J. Biol. Chem., June 27, 2003; 278(27): 25179 - 25190. [Abstract] [Full Text] [PDF]

				V. L. Kinnula and J. D. Crapo Superoxide Dismutases in the Lung and Human Lung Diseases Am. J. Respir. Crit. Care Med., June 15, 2003; 167(12): 1600 - 1619. [Abstract] [Full Text] [PDF]

				Y. Zhang, T. Tazzeo, S. Hirota, and L. J. Janssen Vasodilatory and Electrophysiological Actions of 8-iso-Prostaglandin E2 in Porcine Coronary Artery J. Pharmacol. Exp. Ther., June 1, 2003; 305(3): 1054 - 1060. [Abstract] [Full Text] [PDF]

				X.-L. Chen, Q. Zhang, R. Zhao, X. Ding, P. E. Tummala, and R. M. Medford Rac1 and Superoxide Are Required for the Expression of Cell Adhesion Molecules Induced by Tumor Necrosis Factor-alpha in Endothelial Cells J. Pharmacol. Exp. Ther., May 1, 2003; 305(2): 573 - 580. [Abstract] [Full Text] [PDF]

				V. J. Thannickal The paradox of reactive oxygen species: injury, signaling, or both? Am J Physiol Lung Cell Mol Physiol, January 1, 2003; 284(1): L24 - L25. [Full Text] [PDF]

				N. L. Parinandi, M. A. Kleinberg, P. V. Usatyuk, R. J. Cummings, A. Pennathur, A. J. Cardounel, J. L. Zweier, J. G. N. Garcia, and V. Natarajan Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells Am J Physiol Lung Cell Mol Physiol, January 1, 2003; 284(1): L26 - L38. [Abstract] [Full Text] [PDF]

				G. Lebuffe, P. T. Schumacker, Z.-H. Shao, T. Anderson, H. Iwase, and T. L. Vanden Hoek ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H299 - H308. [Abstract] [Full Text] [PDF]