| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Vascular Physiology Group, Department of Cell Biology and Physiology, Health Sciences Center, University of New Mexico, Albuquerque, New Mexico 87131-5218
Female rats develop
less severe pulmonary hypertension (PH) in response to chronic hypoxia
compared with males, thus implicating a potential role for ovarian
hormones in mediating this gender difference. Considering that estrogen
upregulates endothelial nitric oxide (NO) synthase (eNOS) in systemic
vascular tissue, we hypothesized that estrogen inhibits hypoxic PH by
increasing eNOS expression and activity. To test this hypothesis, we
examined responses to the endothelium-derived NO-dependent dilator
ionomycin and the NO donors
S-nitroso-N-acetylpenicillamine and spermine NONOate in U-46619-constricted, isolated, saline-perfused lungs from
the following groups: 1) normoxic rats with intact ovaries, 2) chronic hypoxic (CH) rats with intact ovaries,
3) CH ovariectomized rats given 17
-estradiol
(E2), and 4) CH ovariectomized rats given
vehicle. Additional experiments assessed pulmonary eNOS levels in each
group by Western blotting. Our findings indicate that E2
attenuated chronic hypoxia-induced right ventricular hypertrophy,
pulmonary arterial remodeling, and polycythemia. Furthermore, although
CH augmented vasodilatory responsiveness to ionomycin and increased
pulmonary eNOS expression, these responses were not potentiated by
E2. Finally, responses to
S-nitroso-N-acetylpenicillamine and spermine
NONOate were similarly attenuated in all CH groups compared with
normoxic control groups. We conclude that the inhibitory influence of
E2 on chronic hypoxia-induced PH is not associated with
increased eNOS expression or activity.
chronic hypoxia; right ventricular hypertrophy; vascular remodeling; nitric oxide-dependent vasodilation; endothelial nitric oxide synthase
This article has been cited by other articles:
|
|
 |
|
  T. Lahm Sex differences in COPD Eur. Respir. J., July 1, 2009; 34(1): 288 - 289. [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Snow, V. Kitzis, C. E. Norton, S. N. Torres, K. D. Johnson, N. L. Kanagy, B. R. Walker, and T. C. Resta Differential effects of chronic hypoxia and intermittent hypocapnic and eucapnic hypoxia on pulmonary vasoreactivity J Appl Physiol, January 1, 2008; 104(1): 110 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. G. Chicoine, M. L. Paffett, M. R. Girton, M. J. Metropoulus, M. S. Joshi, J. A. Bauer, L. D. Nelin, T. C. Resta, and B. R. Walker Maturational changes in the regulation of pulmonary vascular tone by nitric oxide in neonatal rats Am J Physiol Lung Cell Mol Physiol, November 1, 2007; 293(5): L1261 - L1270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Lahm, K. M. Patel, P. R. Crisostomo, T. A. Markel, M. Wang, C. Herring, and D. R. Meldrum Endogenous estrogen attenuates pulmonary artery vasoreactivity and acute hypoxic pulmonary vasoconstriction: the effects of sex and menstrual cycle Am J Physiol Endocrinol Metab, September 1, 2007; 293(3): E865 - E871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Jernigan, B. R. S. Broughton, B. R. Walker, and T. C. Resta Impaired NO-dependent inhibition of store- and receptor-operated calcium entry in pulmonary vascular smooth muscle after chronic hypoxia Am J Physiol Lung Cell Mol Physiol, March 1, 2006; 290(3): L517 - L525. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-C. Chan, F.-P. Leung, X. Yao, C.-W. Lau, P. M. Vanhoutte, and Y. Huang Raloxifene Relaxes Rat Pulmonary Arteries and Veins: Roles of Gender, Endothelium, and Antagonism of Ca2+ Influx J. Pharmacol. Exp. Ther., March 1, 2005; 312(3): 1266 - 1271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Jernigan, B. R. Walker, and T. C. Resta Chronic hypoxia augments protein kinase G-mediated Ca2+ desensitization in pulmonary vascular smooth muscle through inhibition of RhoA/Rho kinase signaling Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1220 - L1229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G. Chicoine, E. Tzeng, R. Bryan, S. Saenz, M. L. Paffett, J. Jones, C. R. Lyons, T. C. Resta, L. D. Nelin, and B. R. Walker Intratracheal adenoviral-mediated delivery of iNOS decreases pulmonary vasoconstrictor responses in rats J Appl Physiol, November 1, 2004; 97(5): 1814 - 1822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Jernigan, B. R. Walker, and T. C. Resta Endothelium-derived reactive oxygen species and endothelin-1 attenuate NO-dependent pulmonary vasodilation following chronic hypoxia Am J Physiol Lung Cell Mol Physiol, October 1, 2004; 287(4): L801 - L808. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Murata, M. Hori, K. Sakamoto, H. Karaki, and H. Ozaki Dexamethasone Blocks Hypoxia-induced Endothelial Dysfunction in Organ-cultured Pulmonary Arteries Am. J. Respir. Crit. Care Med., September 15, 2004; 170(6): 647 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Jernigan, T. C. Resta, and B. R. Walker Contribution of oxygen radicals to altered NO-dependent pulmonary vasodilation in acute and chronic hypoxia Am J Physiol Lung Cell Mol Physiol, May 1, 2004; 286(5): L947 - L955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Jernigan, B. R. Walker, and T. C. Resta Pulmonary PKG-1 is upregulated following chronic hypoxia Am J Physiol Lung Cell Mol Physiol, September 1, 2003; 285(3): L634 - L642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Hampl, J. Bibova, I. Ostadalova, V. Povysilova, and J. Herget Gender differences in the long-term effects of perinatal hypoxia on pulmonary circulation in rats Am J Physiol Lung Cell Mol Physiol, August 1, 2003; 285(2): L386 - L392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. Resta, B. R. Walker, M. R. Eichinger, and M. P. Doyle Rate of NO scavenging alters effects of recombinant hemoglobin solutions on pulmonary vasoreactivity J Appl Physiol, October 1, 2002; 93(4): 1327 - 1336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Mukundan, T. C. Resta, and N. L. Kanagy 17beta -Estradiol decreases hypoxic induction of erythropoietin gene expression Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R496 - R504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G. Chicoine, J. W. Avitia, C. Deen, L. D. Nelin, S. Earley, and B. R. Walker Developmental differences in pulmonary eNOS expression in response to chronic hypoxia in the rat J Appl Physiol, July 1, 2002; 93(1): 311 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Earley and T. C. Resta Estradiol attenuates hypoxia-induced pulmonary endothelin-1 gene expression Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L86 - L93. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. Dubey, S. Oparil, B. Imthurn, and E. K. Jackson Sex hormones and hypertension Cardiovasc Res, February 15, 2002; 53(3): 688 - 708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Jernigan and T. C. Resta Chronic hypoxia attenuates cGMP-dependent pulmonary vasodilation Am J Physiol Lung Cell Mol Physiol, June 1, 2002; 282(6): L1366 - L1375. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
