AJP - Lung Columbus Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 280: L248-L257, 2001;
1040-0605/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (22)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jamaluddin, M.
Right arrow Articles by Brasier, A. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jamaluddin, M.
Right arrow Articles by Brasier, A. R.
Vol. 280, Issue 2, L248-L257, February 2001

IFN-beta mediates coordinate expression of antigen-processing genes in RSV-infected pulmonary epithelial cells

Mohammad Jamaluddin1, Shaofei Wang1, Roberto P. Garofalo2,3, Todd Elliott2, Antonella Casola2, Samuel Baron3, and Allan R. Brasier1,4

Departments of 1 Medicine, 2 Pediatrics, and 3 Microbiology and Immunology and 4 Sealy Center for Molecular Science, The University of Texas Medical Branch, Galveston, Texas 77555-1060

Major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTLs) clear respiratory tract infections caused by the pneumovirus respiratory syncytial virus (RSV) and also mediate vaccine-induced pulmonary injury. Herein we examined the mechanism for RSV-induced MHC class I presentation. Like infectious viruses, conditioned medium from RSV-infected cells (RSV-CM) induces naive cells to coordinately express a gene cluster encoding the transporter associated with antigen presentation 1 (TAP1) and low molecular mass protein (LMP) 2 and LMP7. Neutralization of RSV-CM with antibodies to interferon (IFN)-beta largely blocked TAP1/LMP2/LMP7 expression, whereas anti-interleukin-1 antibodies were without effect, and recombinant IFN-beta increased TAP1/LMP2/LMP7 expression to levels produced by RSV-CM. LMP2, LMP7, and TAP1 expression were required for MHC class I upregulation because the irreversible proteasome inhibitor lactacystin or transfection with a competitive TAP1 inhibitor blocked inducible class I expression. We conclude that RSV infection coordinately increases MHC class I expression and proteasome activity through the paracrine action of IFN-beta to induce expression of the TAP1/LMP2/LMP7 locus, an event that may be important in the initiation of CTL-mediated lung injury.

respiratory syncytial virus; pulmonary inflammation; major histocompatibility complex class II locus; ABC transporter; 26S proteasome; interferon-beta


This article has been cited by other articles:


Home page
 J. Virol.Home page
M. Jamaluddin, B. Tian, I. Boldogh, R. P. Garofalo, and A. R. Brasier
Respiratory Syncytial Virus Infection Induces a Reactive Oxygen Species-MSK1-Phospho-Ser-276 RelA Pathway Required for Cytokine Expression
J. Virol., October 15, 2009; 83(20): 10605 - 10615.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
J. Smieja, M. Jamaluddin, A. R. Brasier, and M. Kimmel
Model-based analysis of interferon-{beta} induced signaling pathway
Bioinformatics, October 15, 2008; 24(20): 2363 - 2369.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
L. M. Pletneva, O. Haller, D. D. Porter, G. A. Prince, and J. C. G. Blanco
Induction of type I interferons and interferon-inducible Mx genes during respiratory syncytial virus infection and reinfection in cotton rats
J. Gen. Virol., January 1, 2008; 89(1): 261 - 270.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
P. T. Morrison, L. H. Thomas, M. Sharland, and J. S. Friedland
RSV-infected airway epithelial cells cause biphasic up-regulation of CCR1 expression on human monocytes
J. Leukoc. Biol., June 1, 2007; 81(6): 1487 - 1495.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
I. Martinez, L. Lombardia, B. Garcia-Barreno, O. Dominguez, and J. A. Melero
Distinct gene subsets are induced at different time points after human respiratory syncytial virus infection of A549 cells
J. Gen. Virol., February 1, 2007; 88(2): 570 - 581.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
P. Liu, M. Jamaluddin, K. Li, R. P. Garofalo, A. Casola, and A. R. Brasier
Retinoic Acid-Inducible Gene I Mediates Early Antiviral Response and Toll-Like Receptor 3 Expression in Respiratory Syncytial Virus-Infected Airway Epithelial Cells
J. Virol., February 1, 2007; 81(3): 1401 - 1411.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
T. Peng, S. Kotla, R. E. Bumgarner, and K. E. Gustin
Human rhinovirus attenuates the type I interferon response by disrupting activation of interferon regulatory factor 3.
J. Virol., May 1, 2006; 80(10): 5021 - 5031.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
B. D. Rudd, E. Burstein, C. S. Duckett, X. Li, and N. W. Lukacs
Differential Role for TLR3 in Respiratory Syncytial Virus-Induced Chemokine Expression
J. Virol., March 15, 2005; 79(6): 3350 - 3357.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Ramaswamy, L. Shi, M. M. Monick, G. W. Hunninghake, and D. C. Look
Specific Inhibition of Type I Interferon Signal Transduction by Respiratory Syncytial Virus
Am. J. Respir. Cell Mol. Biol., June 1, 2004; 30(6): 893 - 900.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
K. M. Spann, K.-C. Tran, B. Chi, R. L. Rabin, and P. L. Collins
Suppression of the Induction of Alpha, Beta, and Gamma Interferons by the NS1 and NS2 Proteins of Human Respiratory Syncytial Virus in Human Epithelial Cells and Macrophages
J. Virol., April 15, 2004; 78(8): 4363 - 4369.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
A. J. Easton, J. B. Domachowske, and H. F. Rosenberg
Animal Pneumoviruses: Molecular Genetics and Pathogenesis
Clin. Microbiol. Rev., April 1, 2004; 17(2): 390 - 412.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. Schwarze, D. R. O'Donnell, A. Rohwedder, and P. J. M. Openshaw
Latency and Persistence of Respiratory Syncytial Virus Despite T Cell Immunity
Am. J. Respir. Crit. Care Med., April 1, 2004; 169(7): 801 - 805.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
Y. Zhang, M. Jamaluddin, S. Wang, B. Tian, R. P. Garofalo, A. Casola, and A. R. Brasier
Ribavirin Treatment Up-Regulates Antiviral Gene Expression via the Interferon-Stimulated Response Element in Respiratory Syncytial Virus-Infected Epithelial Cells
J. Virol., May 15, 2003; 77(10): 5933 - 5947.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
E. K. Wansley and G. D. Parks
Naturally Occurring Substitutions in the P/V Gene Convert the Noncytopathic Paramyxovirus Simian Virus 5 into a Virus That Induces Alpha/Beta Interferon Synthesis and Cell Death
J. Virol., September 11, 2002; 76(20): 10109 - 10121.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. J. Cho, T. Hayashi, S. K. Datta, K. Takabayashi, J. H. Van Uden, A. Horner, M. Corr, and E. Raz
IFN-{alpha}{beta} Promote Priming of Antigen-Specific CD8+ and CD4+ T Lymphocytes by Immunostimulatory DNA-Based Vaccines
J. Immunol., May 15, 2002; 168(10): 4907 - 4913.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
Y. Zhang, B. A. Luxon, A. Casola, R. P. Garofalo, M. Jamaluddin, and A. R. Brasier
Expression of Respiratory Syncytial Virus-Induced Chemokine Gene Networks in Lower Airway Epithelial Cells Revealed by cDNA Microarrays
J. Virol., October 1, 2001; 75(19): 9044 - 9058.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online