AJP - Lung Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 280: L286-L297, 2001;
1040-0605/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kwan, M. L.
Right arrow Articles by McDonald, D. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kwan, M. L.
Right arrow Articles by McDonald, D. M.
Vol. 280, Issue 2, L286-L297, February 2001

Airway vasculature after mycoplasma infection: chronic leakiness and selective hypersensitivity to substance P

Marilyn L. Kwan, Antonio D. Gómez, Peter Baluk, Hiroya Hashizume, and Donald M. McDonald

Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, California 94143

Angiogenesis and microvascular remodeling are features of chronic airway inflammation caused by Mycoplasma pulmonis infection in rats. As airway blood vessels undergo remodeling, they become unusually sensitive to substance P-induced plasma leakage. Here we determined whether the remodeled vessels are leaky under baseline conditions, whether their heightened sensitivity is specific to substance P, and whether the leakage is reversible. Four weeks after infection, the amount of baseline leakage of Evans blue in the tracheal mucosa was two to five times the normal level. Gaps < 1 µm in diameter were located between endothelial cells in some remodeled vessels. Substance P, but not platelet-activating factor or 5-hydroxytryptamine, produced an exaggerated leakage response. Inhalation of the beta 2-adrenergic receptor agonist salmeterol reduced the leakage by <60%. We conclude that the blood vessel remodeling after M. pulmonis infection is associated with microvascular leakiness due, in part, to the formation of endothelial gaps. This leakage is accompanied by an abnormal sensitivity to substance P but not to platelet-activating factor or 5-hydroxytryptamine and can be reduced by beta 2-agonists.

angiogenesis; beta 2-adrenoceptor agonists; endothelial cells; Evans blue; inflammation; Mycoplasma pulmonis; salmeterol; vascular permeability; Wistar rats; Fischer 344 rats


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. A. Schwarz, L. Caldwell, D. Cafasso, and H. Zheng
Emerging pulmonary vasculature lacks fate specification
Am J Physiol Lung Cell Mol Physiol, January 1, 2009; 296(1): L71 - L81.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Krebs, J. M. Tikkanen, A. I. Nykanen, J. Wood, M. Jeltsch, S. Yla-Herttuala, P. K. Koskinen, and K. B. Lemstrom
Dual Role of Vascular Endothelial Growth Factor in Experimental Obliterative Bronchiolitis
Am. J. Respir. Crit. Care Med., June 15, 2005; 171(12): 1421 - 1429.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. F. Elsawa, W. Taylor, C. C. Petty, I. Marriott, J. V. Weinstock, and K. L. Bost
Reduced CTL Response and Increased Viral Burden in Substance P Receptor-Deficient Mice Infected with Murine {gamma}-Herpesvirus 68
J. Immunol., March 1, 2003; 170(5): 2605 - 2612.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. M. MCDONALD
Angiogenesis and Remodeling of Airway Vasculature in Chronic Inflammation
Am. J. Respir. Crit. Care Med., November 15, 2001; 164(10): S39 - 45.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
T. Ezaki, P. Baluk, G. Thurston, A. La Barbara, C. Woo, and D. M. McDonald
Time Course of Endothelial Cell Proliferation and Microvascular Remodeling in Chronic Inflammation
Am. J. Pathol., June 1, 2001; 158(6): 2043 - 2055.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online