| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Animal Physiology, Lund University, SE-223 62 Lund, Sweden; and 2 Department of Physiology, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272-0095
We tested the hypothesis
that labor-induced epinephrine release would stimulate alveolar fluid
clearance in preterm fetuses. Preterm fetuses were obtained by cesarean
section from timed-pregnant guinea pigs at 61-69 days
postconception. Fetal guinea pigs were euthanized and placed on
continuous positive airway pressure oxygenation, and an isosmolar 5%
albumin solution was instilled. Alveolar fluid clearance was measured
over 1 h. The fetal lung began to absorb fluid at 64-66 days
postconception, and at birth, alveolar fluid clearance quadrupled.
Baseline alveolar fluid clearance when present was sensitive to
propranolol inhibition and depended on 
-adrenergic stimulation.
Measurements of plasma epinephrine in fetal animals confirmed high
epinephrine levels in 66- to 69-day postconception fetuses.
Prenatal alveolar fluid clearance when present was highly amiloride
sensitive, suggesting that amiloride-sensitive Na+ channels
were critical. Oxytocin-induced labor initiated an amiloride- and
propranolol-sensitive net alveolar fluid clearance in 61-day-gestation animals. Moreover, oxytocin induced significant epinephrine release in
all fetuses. These results have clinical implications for infants delivered by cesarean section before the onset of labor. Use of pharmacological agents to induce labor may reduce the occurrence and
severity of perinatal respiratory distress.
alveolar epithelium; -adrenergic stimulation; infant respiratory
distress syndrome; prenatal development; epinephrine; sodium
transport
This article has been cited by other articles:
|
|
 |
|
  T. Li, S. Koshy, and H. G. Folkesson IL-1{beta}-induced cortisol stimulates lung fluid absorption in fetal guinea pigs via SGK-mediated Nedd4-2 inhibition Am J Physiol Lung Cell Mol Physiol, March 1, 2009; 296(3): L527 - L533. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Greene Making Small Risks Even Smaller N. Engl. J. Med., January 8, 2009; 360(2): 183 - 184. [Full Text] [PDF]
|
|
|
|
|
|
H. G. Folkesson, C. J. Chapin, L. L. Beard, R. Ertsey, M. A. Matthay, and J. A. Kitterman Congenital diaphragmatic hernia prevents absorption of distal air space fluid in late-gestation rat fetuses Am J Physiol Lung Cell Mol Physiol, March 1, 2006; 290(3): L478 - L484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. Nair, T. Li, R. Bhattacharjee, X. Ye, and H. G. Folkesson Oxytocin-induced labor augments IL-1{beta}-stimulated lung fluid absorption in fetal guinea pig lungs Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L1029 - L1038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Mutlu and J. I. Sznajder Mechanisms of pulmonary edema clearance Am J Physiol Lung Cell Mol Physiol, November 1, 2005; 289(5): L685 - L695. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Matthay, L. Robriquet, and X. Fang Alveolar Epithelium: Role in Lung Fluid Balance and Acute Lung Injury Proceedings of the ATS, October 1, 2005; 2(3): 206 - 213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Ye, R. Acharya, J. B. Herbert, S. E. Hamilton, and H. G. Folkesson IL-1{beta} stimulates alveolar fluid absorption in fetal guinea pig lungs via the hypothalamus-pituitary-adrenal gland axis Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L756 - L766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Sheldon, M. B. Escobedo, D. S. Cole, A. K. Dayal, C. Chazotte, H. Minkoff, and F. A. Chervenak Elective Primary Cesarean Delivery N. Engl. J. Med., June 5, 2003; 348(23): 2364 - 2365. [Full Text] [PDF]
|
|
|
|
|
|
I. Tillie-Leblond, B. P. H. Guery, A. Janin, R. Leberre, N. Just, J.-F. Pittet, A.-B. Tonnel, and P. Gosset Chronic bronchial allergic inflammation increases alveolar liquid clearance by TNF-alpha -dependent mechanism Am J Physiol Lung Cell Mol Physiol, December 1, 2002; 283(6): L1303 - L1309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Matthay, H. G. Folkesson, and C. Clerici Lung Epithelial Fluid Transport and the Resolution of Pulmonary Edema Physiol Rev, July 1, 2002; 82(3): 569 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Norlin and H. G. Folkesson Alveolar Epithelial Ion and Fluid Transport: Ca2+-dependent stimulation of alveolar fluid clearance in near-term fetal guinea pigs Am J Physiol Lung Cell Mol Physiol, April 1, 2002; 282(4): L642 - L649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Bland Loss of liquid from the lung lumen in labor: more than a simple "squeeze" Am J Physiol Lung Cell Mol Physiol, April 1, 2001; 280(4): L602 - L605. [Full Text] [PDF]
|
|
|
|
|
|
H. G. Folkesson, M. A. Matthay, C. J. Chapin, N. F. M. Porta, and J. A. Kitterman Pre- and Postnatal Lung Development, Maturation, and Plasticity: Distal air space epithelial fluid clearance in near-term rat fetuses is fast and requires endogenous catecholamines Am J Physiol Lung Cell Mol Physiol, March 1, 2002; 282(3): L508 - L515. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
