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Am J Physiol Lung Cell Mol Physiol 280: L716-L723, 2001;
1040-0605/01 $5.00
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Vol. 280, Issue 4, L716-L723, April 2001

A murine model of smoke inhalation

E. Matthew1, G. Warden2, and J. Dedman1,2

1 Department of Molecular and Cellular Physiology, University of Cincinnati Medical Center, Cinncinnati 45267-0576; and 2 Shriner Burns Hospital for Children, Cincinnati, Ohio 45229

The United States has one of the world's largest per capita fire death rates. House fires alone kill >9,000 Americans annually, and smoke inhalation is the leading cause of mortality from structural fires. Animal models are needed to develop therapies to combat this problem. We have developed a murine model of smoke inhalation through the design, construction, and use of a controlled-environment smoke chamber. There is a direct relationship between the quantity of wood combusted and mortality in mice. As with human victims, the primary cause of death from smoke inhalation is an elevated blood carboxyhemoglobin level. Lethal (78%) and sublethal (50%) carboxyhemoglobin levels were obtained in mice subjected to varying amounts of smoke. Mice exposed to wood smoke demonstrated more dramatic pathology than mice exposed to cotton or polyurethane smoke. A CD-1 model of wood smoke exposure was developed, demonstrating type II cell hypertrophy, cytoplasmic blebbing, cytoplasmic vacuolization, sloughing, hemorrhage, edema, macrophage infiltration, and lymphocyte infiltration. The bronchoalveolar lavage fluid of smoke-exposed mice demonstrated a significant increase in total cell counts compared with those in control mice. These findings are comparable to the lung tissue response observed in human victims of smoke inhalation.

carboxyhemoglobin; smoke inhalation; bronchoalveolar lavage; cell count


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