AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 280: L1040-L1048, 2001;
1040-0605/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (29)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ivy, D. D.
Right arrow Articles by Abman, S. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ivy, D. D.
Right arrow Articles by Abman, S. H.
Vol. 280, Issue 5, L1040-L1048, May 2001

Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction

D. Dunbar Ivy1,2, Ivan F. McMurtry3, Masashi Yanagisawa4, Cheryl E. Gariepy4, Timothy D. Le Cras1,5, Sarah A. Gebb1,5, Kenneth G. Morris3, Richard C. Wiseman4, and Steven H. Abman1,3

1 Pediatric Heart Lung Center and Sections of 2 Pediatric Cardiology, 5 Pediatric Pulmonary Medicine, and 3 Cardiovascular Pulmonary Research Laboratory, University of Colorado School of Medicine and The Children's Hospital, Denver, Colorado 80218; and 4 Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390

Endothelin (ET)-1 contributes to the regulation of pulmonary vascular tone by stimulation of the ETA and ETB receptors. Although activation of the ETA receptor causes vasoconstriction, stimulation of the ETB receptors can elicit either vasodilation or vasoconstriction. To examine the physiological role of the ETB receptor in the pulmonary circulation, we studied a genetic rat model of ETB receptor deficiency [transgenic(sl/sl)]. We hypothesized that deficiency of the ETB receptor would predispose the transgenic(sl/sl) rat lung circulation to enhanced pulmonary vasoconstriction. We found that the lungs of transgenic(sl/sl) rats are ETB deficient because they lack ETB mRNA in the pulmonary vasculature, have minimal ETB receptors as determined with an ET-1 radioligand binding assay, and lack ET-1-mediated pulmonary vasodilation. The transgenic(sl/sl) rats have higher basal pulmonary arterial pressure and vasopressor responses to brief hypoxia or ET-1 infusion. Plasma ET-1 levels are elevated and endothelial nitric oxide synthase protein content and nitric oxide production are diminished in the transgenic(sl/sl) rat lung. These findings suggest that the ETB receptor plays a major physiological role in modulating resting pulmonary vascular tone and reactivity to acute hypoxia. We speculate that impaired ETB receptor activity can contribute to the pathogenesis of pulmonary hypertension.

hypoxia; pulmonary circulation; nitric oxide


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
X. Wang, M. Tong, S. Chinta, J. U. Raj, and Y. Gao
Hypoxia-induced reactive oxygen species downregulate ETB receptor-mediated contraction of rat pulmonary arteries
Am J Physiol Lung Cell Mol Physiol, March 1, 2006; 290(3): L570 - L578.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. M. Berger, C. Hesse, C. Dehnert, H. Siedler, P. Kleinbongard, H. J. Bardenheuer, M. Kelm, P. Bartsch, and W. E. Haefeli
Hypoxia Impairs Systemic Endothelial Function in Individuals Prone to High-Altitude Pulmonary Edema
Am. J. Respir. Crit. Care Med., September 15, 2005; 172(6): 763 - 767.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
T. Carpenter, S. Schomberg, W. Steudel, J. Ozimek, K. Colvin, K. Stenmark, and D. D. Ivy
Endothelin B Receptor Deficiency Predisposes to Pulmonary Edema Formation via Increased Lung Vascular Endothelial Cell Growth Factor Expression
Circ. Res., September 5, 2003; 93(5): 456 - 463.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. C. Blumberg, K. Wolf, M. Arzt, C. Lorenz, G. A. J. Riegger, and M. Pfeifer
Effects of ET-A receptor blockade on eNOS gene expression in chronic hypoxic rat lungs
J Appl Physiol, February 1, 2003; 94(2): 446 - 452.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
S. Granchi, G.B. Vannelli, L. Vignozzi, C. Crescioli, P. Ferruzzi, R. Mancina, M.C. Vinci, G. Forti, S. Filippi, M. Luconi, et al.
Expression and regulation of endothelin-1 and its receptors in human penile smooth muscle cells
Mol. Hum. Reprod., December 1, 2002; 8(12): 1053 - 1064.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
Y. Coe, S. J. Haleen, K. M. Welch, Y.-A. Liu, and F. Coceani
The Endothelin A Receptor Antagonists PD 156707 (CI-1020) and PD 180988 (CI-1034) Reverse the Hypoxic Pulmonary Vasoconstriction in the Perinatal Lamb
J. Pharmacol. Exp. Ther., August 1, 2002; 302(2): 672 - 680.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. G. Bianciotti and A. J. de Bold
Natriuretic peptide gene expression in DOCA-salt hypertension after blockade of type B endothelin receptor
Am J Physiol Heart Circ Physiol, March 1, 2002; 282(3): H1127 - H1134.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. G. Perry, M. M. Molero, A. D. Giulumian, P. V. G. Katakam, J. S. Pollock, D. M. Pollock, and L. C. Fuchs
ETB receptor-deficient rats exhibit reduced contraction to ET-1 despite an increase in ETA receptors
Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2680 - H2686.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. D. Ivy, M. Yanagisawa, C. E. Gariepy, S. A. Gebb, K. L. Colvin, and I. F. McMurtry
Exaggerated hypoxic pulmonary hypertension in endothelin B receptor-deficient rats
Am J Physiol Lung Cell Mol Physiol, April 1, 2002; 282(4): L703 - L712.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online