AJP - Lung Columbus Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 280: L823-L838, 2001;
1040-0605/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (118)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Costa, R. H.
Right arrow Articles by Lim, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Costa, R. H.
Right arrow Articles by Lim, L.
Vol. 280, Issue 5, L823-L838, May 2001

INVITED REVIEW
Transcription factors in mouse lung development and function

Robert H. Costa, Vladimir V. Kalinichenko, and Lorena Lim

Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607-7170

Development of the mouse lung initiates on day 9.5 postcoitum from the laryngotracheal groove and involves mesenchymal-epithelial interactions, in particular, those between the splanchnic mesoderm and epithelial cells (derived from foregut endoderm) that induce cellular proliferation, migration, and differentiation, resulting in branching morphogenesis. This developmental process mediates formation of the pulmonary bronchiole tree and integrates a terminal alveolar region with an extensive endothelial capillary bed, which facilitates efficient gas exchange with the circulatory system. The major function of the mesenchymal-epithelial signaling is to potentiate the activity or expression of cell type-specific transcription factors in the developing lung, which, in turn, cooperatively bind to distinct promoter regions and activate target gene expression. In this review, we focus on the role of transcription factors in lung morphogenesis and the maintenance of differentiated gene expression. These lung transcription factors include forkhead box A2 [also known as hepatocyte nuclear factor (HNF)-3beta ], HNF-3/forkhead homolog (HFH)-8 [also known as FoxF1 or forkhead-related activator-1], HNF-3/forkhead homolog-4 (also known as FoxJ1), thyroid transcription factor-1 (Nkx2.1), and homeodomain box A5 transcription factors, the zinc finger Gli (mouse homologs of the Drosophila cubitus interruptus) and GATA transcription factors, and the basic helix-loop-helix Pod1 transcription factor. We summarize the phenotypes of transgenic and knockout mouse models, which define important functions of these transcription factors in cellular differentiation and lung branching morphogenesis.

winged helix/forkhead box deoxyribonucleic acid binding domain; hepatocyte nuclear factor-3/forkhead homolog; homeodomain box; Nkx2.1; GATA; Gli; Pod1


This article has been cited by other articles:


Home page
 DevelopmentHome page
N. Jin, S.-N. Cho, M. G. Raso, I. Wistuba, Y. Smith, Y. Yang, J. M. Kurie, R. Yen, C. M. Evans, T. Ludwig, et al.
Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis
Development, October 1, 2009; 136(19): 3347 - 3356.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. E. Tilley, B.-G. Harvey, A. Heguy, N. R. Hackett, R. Wang, T. P. O'Connor, and R. G. Crystal
Down-regulation of the Notch Pathway in Human Airway Epithelium in Association with Smoking and Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., March 15, 2009; 179(6): 457 - 466.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
K. M. Kransler, B. P. McGarrigle, D. D. Swartz, and J. R. Olson
Lung Development in the Holtzman Rat is Adversely Affected by Gestational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin
Toxicol. Sci., February 1, 2009; 107(2): 498 - 511.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
T. V. Kalin, L. Meliton, A. Y. Meliton, X. Zhu, J. A. Whitsett, and V. V. Kalinichenko
Pulmonary Mastocytosis and Enhanced Lung Inflammation in Mice Heterozygous Null for the Foxf1 Gene
Am. J. Respir. Cell Mol. Biol., October 1, 2008; 39(4): 390 - 399.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Loscertales, A. J. Mikels, J. K.-H. Hu, P. K. Donahoe, and D. J. Roberts
Chick pulmonary Wnt5a directs airway and vascular tubulogenesis
Development, April 1, 2008; 135(7): 1365 - 1376.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
P. Minoo, L. Hu, N. Zhu, Z. Borok, S. Bellusci, J. Groffen, D. Kardassis, and C. Li
SMAD3 prevents binding of NKX2.1 and FOXA1 to the SpB promoter through its MH1 and MH2 domains
Nucleic Acids Res., January 17, 2008; 36(1): 179 - 188.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. K. Lovgren, M. Kovarova, and B. H. Koller
cPGES/p23 Is Required for Glucocorticoid Receptor Function and Embryonic Growth but Not Prostaglandin E2 Synthesis
Mol. Cell. Biol., June 15, 2007; 27(12): 4416 - 4430.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
D. Malin, I.-M. Kim, E. Boetticher, T. V. Kalin, S. Ramakrishna, L. Meliton, V. Ustiyan, X. Zhu, and V. V. Kalinichenko
Forkhead Box F1 Is Essential for Migration of Mesenchymal Cells and Directly Induces Integrin-Beta3 Expression
Mol. Cell. Biol., April 1, 2007; 27(7): 2486 - 2498.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
P. Minoo, L. Hu, Y. Xing, N. L. Zhu, H. Chen, M. Li, Z. Borok, and C. Li
Physical and Functional Interactions between Homeodomain NKX2.1 and Winged Helix/Forkhead FOXA1 in Lung Epithelial Cells
Mol. Cell. Biol., March 15, 2007; 27(6): 2155 - 2165.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
Y. Maeda, V. Dave, and J. A. Whitsett
Transcriptional Control of Lung Morphogenesis
Physiol Rev, January 1, 2007; 87(1): 219 - 244.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. J. Homer, Z. Zhu, L. Cohn, C. G. Lee, W. I. White, S. Chen, and J. A. Elias
Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation
Am J Physiol Lung Cell Mol Physiol, September 1, 2006; 291(3): L502 - L511.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. L. Mucenski, J. M. Nation, A. R. Thitoff, V. Besnard, Y. Xu, S. E. Wert, N. Harada, M. M. Taketo, M. T. Stahlman, and J. A. Whitsett
{beta}-Catenin regulates differentiation of respiratory epithelial cells in vivo
Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L971 - L979.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
V. Besnard, S. E. Wert, K. H. Kaestner, and J. A. Whitsett
Stage-specific regulation of respiratory epithelial cell differentiation by Foxa1
Am J Physiol Lung Cell Mol Physiol, November 1, 2005; 289(5): L750 - L759.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
R. Alazard, M. Blaud, S. Elbaz, C. Vossen, G. Icre, G. Joseph, L. Nieto, and M. Erard
Identification of the 'NORE' (N-Oct-3 responsive element), a novel structural motif and composite element
Nucleic Acids Res., March 14, 2005; 33(5): 1513 - 1523.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
G. Steele-Perkins, C. Plachez, K. G. Butz, G. Yang, C. J. Bachurski, S. L. Kinsman, E. D. Litwack, L. J. Richards, and R. M. Gronostajski
The Transcription Factor Gene Nfib Is Essential for both Lung Maturation and Brain Development
Mol. Cell. Biol., January 15, 2005; 25(2): 685 - 698.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B. Wang, J. Weidenfeld, M. M. Lu, S. Maika, W. A. Kuziel, E. E. Morrisey, and P. W. Tucker
Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation
Development, September 15, 2004; 131(18): 4477 - 4487.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. Halmos, D. S. Basseres, S. Monti, F. D'Alo, T. Dayaram, K. Ferenczi, B. J. Wouters, C. S. Huettner, T. R. Golub, and D. G. Tenen
A Transcriptional Profiling Study of CCAAT/Enhancer Binding Protein Targets Identifies Hepatocyte Nuclear Factor 3{beta} as a Novel Tumor Suppressor in Lung Cancer
Cancer Res., June 15, 2004; 64(12): 4137 - 4147.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
V. V. Kalinichenko, G. A. Gusarova, I.-M. Kim, B. Shin, H. M. Yoder, J. Clark, A. M. Sapozhnikov, J. A. Whitsett, and R. H. Costa
Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development
Am J Physiol Lung Cell Mol Physiol, March 1, 2004; 286(3): L521 - L530.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Q.-G. V. Nguyen, J. N. Buskin, C. L. Himeda, M. A. Shield, and S. D. Hauschka
Differences in the Function of Three Conserved E-boxes of the Muscle Creatine Kinase Gene in Cultured Myocytes and in Transgenic Mouse Skeletal and Cardiac Muscle
J. Biol. Chem., November 21, 2003; 278(47): 46494 - 46505.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. N. Cassel and M. Nord
C/EBP transcription factors in the lung epithelium
Am J Physiol Lung Cell Mol Physiol, October 1, 2003; 285(4): L773 - L781.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. V. Kalinichenko, G. A. Gusarova, Y. Tan, I-C. Wang, M. L. Major, X. Wang, H. M. Yoder, and R. H. Costal
Ubiquitous Expression of the Forkhead Box M1B Transgene Accelerates Proliferation of Distinct Pulmonary Cell Types following Lung Injury
J. Biol. Chem., September 26, 2003; 278(39): 37888 - 37894.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M-C.W. Yang, B. Wang, J.C. Weissler, L.R. Margraf, and Y-S. Yang
BR22, a 26 kDa thyroid transcription factor-1 associated protein (TAP26), is expressed in human lung cells
Eur. Respir. J., July 1, 2003; 22(1): 28 - 34.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
A E Bonner, W J Lemon, and M You
Gene expression signatures identify novel regulatory pathways during murine lung development: implications for lung tumorigenesis
J. Med. Genet., June 1, 2003; 40(6): 408 - 417.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Y. You, E. J. Richer, T. Huang, and S. L. Brody
Growth and differentiation of mouse tracheal epithelial cells: selection of a proliferative population
Am J Physiol Lung Cell Mol Physiol, December 1, 2002; 283(6): L1315 - L1321.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Wang, K. Krupczak-Hollis, Y. Tan, M. B. Dennewitz, G. R. Adami, and R. H. Costa
Increased Hepatic Forkhead Box M1B (FoxM1B) Levels in Old-aged Mice Stimulated Liver Regeneration through Diminished p27Kip1 Protein Levels and Increased Cdc25B Expression
J. Biol. Chem., November 8, 2002; 277(46): 44310 - 44316.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
R Mahadeva and S D Shapiro
Chronic obstructive pulmonary disease * 3: Experimental animal models of pulmonary emphysema
Thorax, October 1, 2002; 57(10): 908 - 914.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. V. Kalinichenko, Y. Zhou, D. Bhattacharyya, W. Kim, B. Shin, K. Bambal, and R. H. Costa
Haploinsufficiency of the Mouse Forkhead Box f1 Gene Causes Defects in Gall Bladder Development
J. Biol. Chem., March 29, 2002; 277(14): 12369 - 12374.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
I. F. McMurtry
Editorial: Introduction: pre- and postnatal lung development, maturation, and plasticity
Am J Physiol Lung Cell Mol Physiol, March 1, 2002; 282(3): L341 - L344.
[Full Text] [PDF]

Home page
 DevelopmentHome page
H. Yang, M. M. Lu, L. Zhang, J. A. Whitsett, and E. E. Morrisey
GATA6 regulates differentiation of distal lung epithelium
Development, January 5, 2002; 129(9): 2233 - 2246.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
X. Wang, E. Quail, N.-J. Hung, Y. Tan, H. Ye, and R. H. Costa
Increased levels of forkhead box M1B transcription factor in transgenic mouse hepatocytes prevent age-related proliferation defects in regenerating liver
PNAS, September 25, 2001; 98(20): 11468 - 11473.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. Lim, V. V. Kalinichenko, J. A. Whitsett, and R. H. Costa
Fusion of lung lobes and vessels in mouse embryos heterozygous for the forkhead box f1 targeted allele
Am J Physiol Lung Cell Mol Physiol, May 1, 2002; 282(5): L1012 - L1022.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
V. V. Kalinichenko, Y. Zhou, B. Shin, D. B. Stolz, S. C. Watkins, J. A. Whitsett, and R. H. Costa
Wild-type levels of the mouse Forkhead Box f1 gene are essential for lung repair
Am J Physiol Lung Cell Mol Physiol, June 1, 2002; 282(6): L1253 - L1265.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online