AJP - Lung Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 280: L1233-L1241, 2001;
1040-0605/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (20)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Soejima, K.
Right arrow Articles by Traber, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Soejima, K.
Right arrow Articles by Traber, D. L.
Vol. 280, Issue 6, L1233-L1241, June 2001

Pathophysiological analysis of combined burn and smoke inhalation injuries in sheep

Kazutaka Soejima1, Frank C. Schmalstieg2, Hiroyuki Sakurai1, Lillian D. Traber3, and Daniel L. Traber3

1 Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Tokyo 162-8666, Japan; and 3 Department of Anesthesiology and 2 Department of Pediatrics, University of Texas Medical Branch and Shriners Burns Institute, Galveston, Texas 77555-0591

We investigated the pathophysiological alterations seen with combined burn and smoke inhalation injuries by focusing on pulmonary vascular permeability and cardiopulmonary function compared with those seen with either burn or smoke inhalation injury alone. To estimate the effect of factors other than injury, the experiments were also performed with no injury in the same experimental setting. Lung edema was most severe in the combined injury group. Our study revealed that burn injury does not affect protein leakage from the pulmonary microvasculature, even when burn is associated with smoke inhalation injury. The severity of lung edema seen with the combined injury is mainly due to augmentation of pulmonary microvascular permeability to fluid, not to protein. Cardiac dysfunction after the combined injury consisted of at least two phases. An initial depression was mostly related to hypovolemia due to burn injury. It was improved by a large amount of fluid resuscitation. The later phase, which was indicated to be a myocardial contractile dysfunction independent of the Starling equation, seemed to be correlated with smoke inhalation injury.

pulmonary vascular permeability; lung edema formation; myocardial depression


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
M. Lange, P. Enkhbaatar, D. L. Traber, R. A. Cox, S. Jacob, B. P. Mathew, A. Hamahata, L. D. Traber, D. N. Herndon, and H. K. Hawkins
Role of calcitonin gene-related peptide (CGRP) in ovine burn and smoke inhalation injury
J Appl Physiol, July 1, 2009; 107(1): 176 - 184.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Enkhbaatar, K. Murakami, K. Shimoda, A. Mizutani, L. Traber, G. Phillips, J. Parkinson, J. R. Salsbury, N. Biondo, F. Schmalstieg, et al.
Inducible nitric oxide synthase dimerization inhibitor prevents cardiovascular and renal morbidity in sheep with combined burn and smoke inhalation injury
Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2430 - H2436.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Enkhbaatar, K. Murakami, K. Shimoda, A. Mizutani, L. Traber, G. B. Phillips, J. F. Parkinson, R. Cox, H. Hawkins, D. Herndon, et al.
The Inducible Nitric Oxide Synthase Inhibitor BBS-2 Prevents Acute Lung Injury in Sheep after Burn and Smoke Inhalation Injury
Am. J. Respir. Crit. Care Med., April 1, 2003; 167(7): 1021 - 1026.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online