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-mediated fibrotic responses in the lung
1 Department of Pathology and Molecular Medicine and Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada L8N 3Z5; 2 Medizinische Klinik, Julius-Maximilians-Universität, 97080 Würzburg, Germany; and 3 University of Rochester School of Medicine, Rochester, New York 14642-8692
Transforming growth factor (TGF)-
is a key cytokine in
the pathogenesis of pulmonary fibrosis, and pharmacological
interference with TGF- can ameliorate the fibrotic tissue response.
The small proteoglycans decorin and biglycan are able to bind and
inhibit TGF- activity in vitro. Although decorin has anti-TGF-
properties in vivo, little is known about the physiological role of
biglycan in vivo. Adenoviral gene transfer was used to overexpress
active TGF-, decorin, and biglycan in cell culture and in murine
lungs. Both proteoglycans were able to interfere with TGF-
bioactivity in vitro in a dose-dependant manner. In vivo,
overexpression of TGF- resulted in marked lung fibrosis, which was
significantly reduced by concomitant overexpression of decorin.
Biglycan, however, had no significant effect on lung fibrosis induced
by TGF-. The data suggest that differences in tissue distribution
are responsible for the different effects on TGF- bioactivity in
vivo, indicating that decorin, but not biglycan, has potential
therapeutic value in fibrotic disorders of the lung.
pulmonary fibrosis; extracellular matrix; treatment
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