AJP - Lung Columbus Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 280: L1327-L1334, 2001;
1040-0605/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (56)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kolb, M.
Right arrow Articles by Gauldie, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kolb, M.
Right arrow Articles by Gauldie, J.
Vol. 280, Issue 6, L1327-L1334, June 2001

Proteoglycans decorin and biglycan differentially modulate TGF-beta -mediated fibrotic responses in the lung

Martin Kolb1,2, Peter J. Margetts1, Patricia J. Sime3, and Jack Gauldie1

1 Department of Pathology and Molecular Medicine and Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada L8N 3Z5; 2 Medizinische Klinik, Julius-Maximilians-Universität, 97080 Würzburg, Germany; and 3 University of Rochester School of Medicine, Rochester, New York 14642-8692

Transforming growth factor (TGF)-beta is a key cytokine in the pathogenesis of pulmonary fibrosis, and pharmacological interference with TGF-beta can ameliorate the fibrotic tissue response. The small proteoglycans decorin and biglycan are able to bind and inhibit TGF-beta activity in vitro. Although decorin has anti-TGF-beta properties in vivo, little is known about the physiological role of biglycan in vivo. Adenoviral gene transfer was used to overexpress active TGF-beta , decorin, and biglycan in cell culture and in murine lungs. Both proteoglycans were able to interfere with TGF-beta bioactivity in vitro in a dose-dependant manner. In vivo, overexpression of TGF-beta resulted in marked lung fibrosis, which was significantly reduced by concomitant overexpression of decorin. Biglycan, however, had no significant effect on lung fibrosis induced by TGF-beta . The data suggest that differences in tissue distribution are responsible for the different effects on TGF-beta bioactivity in vivo, indicating that decorin, but not biglycan, has potential therapeutic value in fibrotic disorders of the lung.

pulmonary fibrosis; extracellular matrix; treatment


This article has been cited by other articles:


Home page
 Am J Clin PatholHome page
T. Gambichler, A. Kreuter, M. Skrygan, B. Burkert, P. Altmeyer, and G. Schieren
Decorin Is Significantly Overexpressed in Nephrogenic Systemic Fibrosis
Am J Clin Pathol, July 1, 2009; 132(1): 139 - 143.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Khan, E. S. Muise, P. Iyengar, Z. V. Wang, M. Chandalia, N. Abate, B. B. Zhang, P. Bonaldo, S. Chua, and P. E. Scherer
Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI
Mol. Cell. Biol., March 15, 2009; 29(6): 1575 - 1591.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. J. Scotton and R. C. Chambers
Molecular Targets in Pulmonary Fibrosis: The Myofibroblast in Focus
Chest, October 1, 2007; 132(4): 1311 - 1321.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
B. M. Zhao and F. M. Hoffmann
Inhibition of Transforming Growth Factor-beta1-induced Signaling and Epithelial-to-Mesenchymal Transition by the Smad-binding Peptide Aptamer Trx-SARA
Mol. Biol. Cell, September 1, 2006; 17(9): 3819 - 3831.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. Pini, C. Torregiani, J. G. Martin, Q. Hamid, and M. S. Ludwig
Airway remodeling in allergen-challenged Brown Norway rats: distribution of proteoglycans
Am J Physiol Lung Cell Mol Physiol, June 1, 2006; 290(6): L1052 - L1058.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
L. Todorova, E. Gurcan, A. Miller-Larsson, and G. Westergren-Thorsson
Lung Fibroblast Proteoglycan Production Induced by Serum Is Inhibited by Budesonide and Formoterol
Am. J. Respir. Cell Mol. Biol., January 1, 2006; 34(1): 92 - 100.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
C. W. Frevert and P. L. Sannes
Matrix proteoglycans as effector molecules for epithelial cell function
Eur. Respir. Rev., December 1, 2005; 14(97): 137 - 144.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. Aoki, M. Kurabayashi, Y. Hasegawa, and I. Kojima
Attenuation of Bleomycin-induced Pulmonary Fibrosis by Follistatin
Am. J. Respir. Crit. Care Med., September 15, 2005; 172(6): 713 - 720.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. A. Buczek-Thomas, E. C. Lucey, P. J. Stone, C. L. Chu, C. B. Rich, I. Carreras, R. H. Goldstein, J. A. Foster, and M. A. Nugent
Elastase Mediates the Release of Growth Factors from Lung In Vivo
Am. J. Respir. Cell Mol. Biol., September 1, 2004; 31(3): 344 - 350.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. I. Bechara, L. A. S. Brown, J. Roman, P. C. Joshi, and D. M. Guidot
Transforming Growth Factor {beta}1 Expression and Activation Is Increased in the Alcoholic Rat Lung
Am. J. Respir. Crit. Care Med., July 15, 2004; 170(2): 188 - 194.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
R. Shimizu-Hirota, H. Sasamura, M. Kuroda, E. Kobayashi, M. Hayashi, and T. Saruta
Extracellular Matrix Glycoprotein Biglycan Enhances Vascular Smooth Muscle Cell Proliferation and Migration
Circ. Res., April 30, 2004; 94(8): 1067 - 1074.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Schaefer, K.-F. Beck, I. Raslik, S. Walpen, D. Mihalik, M. Micegova, K. Macakova, E. Schonherr, D. G. Seidler, G. Varga, et al.
Biglycan, a Nitric Oxide-regulated Gene, Affects Adhesion, Growth, and Survival of Mesangial Cells
J. Biol. Chem., July 3, 2003; 278(28): 26227 - 26237.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Troup, C. Njue, E. V. Kliewer, M. Parisien, C. Roskelley, S. Chakravarti, P. J. Roughley, L. C. Murphy, and P. H. Watson
Reduced Expression of the Small Leucine-rich Proteoglycans, Lumican, and Decorin Is Associated with Poor Outcome in Node-negative Invasive Breast Cancer
Clin. Cancer Res., January 1, 2003; 9(1): 207 - 214.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Kolb, P. Bonniaud, T. Galt, P. J. Sime, M. M. Kelly, P. J. Margetts, and J. Gauldie
Differences in the Fibrogenic Response after Transfer of Active Transforming Growth Factor-{beta}1 Gene to Lungs of "Fibrosis-prone" and "Fibrosis-resistant" Mouse Strains
Am. J. Respir. Cell Mol. Biol., August 1, 2002; 27(2): 141 - 150.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
L. Schaefer, K. Macakova, I. Raslik, M. Micegova, H.-J. Grone, E. Schonherr, H. Robenek, F. G. Echtermeyer, S. Grassel, P. Bruckner, et al.
Absence of Decorin Adversely Influences Tubulointerstitial Fibrosis of the Obstructed Kidney by Enhanced Apoptosis and Increased Inflammatory Reaction
Am. J. Pathol., March 1, 2002; 160(3): 1181 - 1191.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online