AJP - Lung AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 280: L1348-L1358, 2001;
1040-0605/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (4)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Haley, K. J.
Right arrow Articles by Lilly, C. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Haley, K. J.
Right arrow Articles by Lilly, C. M.
Vol. 280, Issue 6, L1348-L1358, June 2001

Developmental expression of neurokinin A and functional neurokinin-2 receptors in lung

Kathleen J. Haley1, Mary E. Sunday2, Rapin Osathanondh3, Juan Du1, Charie Vathanaprida2, Vladimir V. Karpitsky4, James E. Krause4, and Craig M. Lilly1

Departments of 1 Medicine, 2 Pathology, and 3 Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts 02115; and 4 Department of Pathology, Washington University at St. Louis, St. Louis, Missouri 63110

Peribronchial smooth muscle constriction causes airway stretch, an important mechanical force in developing lung. Little is known about factors influencing these spontaneously active muscle elements. We measured contractile activity of neurokinin (NK) receptors on fetal intrapulmonary smooth muscle by tracheal perfusion assay (n = 11). Injecting either capsaicin or the NK2 receptor agonist [NLE10]NKA resulted in significant (P < 0.05) bronchoconstriction. A specific NK2 receptor antagonist inhibited constriction caused by endogenous tachykinins released by capsaicin. We then examined NK2 receptor (n = 44) and NKA (n = 23) ontogeny in human lung. NKA immunostaining was identified in peribronchial nerves in samples with gestational age >12 wk. NK2 receptor protein was identified in peribronchial and perivascular smooth muscle. These results indicate that endogenous tachykinins released by the developing lung act via NK2 receptors to cause smooth muscle constriction. We speculate that tachykinins could modulate lung development.

tachykinins; mechanical transduction; immunohistochemistry


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. J. Haley, M. E. Sunday, Y. Porrata, C. Kelley, A. Twomey, A. Shahsafaei, B. Galper, L. A. Sonna, and C. M. Lilly
Ontogeny of the eotaxins in human lung
Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L214 - L224.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. M. Lilly, H. Tateno, T. Oguma, E. Israel, and L. A. Sonna
Effects of Allergen Challenge on Airway Epithelial Cell Gene Expression
Am. J. Respir. Crit. Care Med., March 15, 2005; 171(6): 579 - 586.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online