AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 281: L677-L684, 2001;
1040-0605/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (25)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Song, Y.
Right arrow Articles by Meng, X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Song, Y.
Right arrow Articles by Meng, X.
Vol. 281, Issue 3, L677-L684, September 2001

A low level of TNF-alpha mediates hemorrhage-induced acute lung injury via p55 TNF receptor

Yong Song1, Lihua Ao1, Christopher D. Raeburn1, Casey M. Calkins1, Edward Abraham2, Alden H. Harken1, and Xianzhong Meng1

1 Department of Surgery and 2 Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262

Acute lung injury after hemorrhagic shock (HS) is associated with the expression of tumor necrosis factor (TNF)-alpha in the lung. However, the role of TNF-alpha and its receptors in this pulmonary disorder remains obscure. This study examined the temporal relationship of pulmonary TNF-alpha production to neutrophil accumulation during HS and determined the role of TNF-alpha in neutrophil accumulation and lung leak. HS was induced in mice by removal of 30% of total blood volume. Lung TNF-alpha was measured by ELISA. Neutrophil accumulation was detected by immunofluorescent staining, and microvascular permeability was assessed using Evans blue dye. Although HS induced a slight and transient increase in lung TNF-alpha , neutrophil accumulation preceded the increase in TNF-alpha . However, lung neutrophil accumulation and lung leak were abrogated in TNF-alpha knockout mice, and both were restored by administration of recombinant TNF-alpha to TNF-alpha knockout mice before HS. Neutrophil accumulation and lung leak were abrogated in mice lacking the p55 TNF-alpha receptor, but neither was influenced by p75 TNF-alpha receptor knockout. This study demonstrates that a low level of pulmonary TNF-alpha is sufficient to mediate HS-induced acute lung injury during HS and that the p55 TNF-alpha receptor plays a dominant role in regulating the pulmonary inflammatory response to HS.

gene knockout; neutrophils; microvascular permeability; mouse; tumor necrosis factor-alpha


This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
A. N. Babu, X. Meng, N. Zou, X. Yang, M. Wang, Y. Song, J. C. Cleveland, M. Weyant, A. Banerjee, and D. A. Fullerton
Lipopolysaccharide stimulation of human aortic valve interstitial cells activates inflammation and osteogenesis.
Ann. Thorac. Surg., July 1, 2008; 86(1): 71 - 76.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
X. Meng, L. Ao, Y. Song, A. Babu, X. Yang, M. Wang, M. J. Weyant, C. A. Dinarello, J. C. Cleveland Jr., and D. A. Fullerton
Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis
Am J Physiol Cell Physiol, January 1, 2008; 294(1): C29 - C35.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. G. Kiang, P. D. Bowman, X. Lu, Y. Li, B. W. Wu, H. H. Loh, K. T. Tsen, and G. C. Tsokos
Geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity: role of inducible nitric oxide synthase
J Appl Physiol, September 1, 2007; 103(3): 1045 - 1055.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. R. Wilson, M. E. Goddard, K. P. O'Dea, S. Choudhury, and M. Takata
Differential roles of p55 and p75 tumor necrosis factor receptors on stretch-induced pulmonary edema in mice
Am J Physiol Lung Cell Mol Physiol, July 1, 2007; 293(1): L60 - L68.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Y.-C. Hsieh, M. Frink, C.-H. Hsieh, M. A. Choudhry, M. G. Schwacha, K. I. Bland, and I. H. Chaudry
Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhage
Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1227 - L1232.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H.-P. Yu, S. Yang, Y.-C. Hsieh, M. A. Choudhry, K. I. Bland, and I. H. Chaudry
Maintenance of lung myeloperoxidase activity in proestrus females after trauma-hemorrhage: upregulation of heme oxygenase-1
Am J Physiol Lung Cell Mol Physiol, September 1, 2006; 291(3): L400 - L406.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. Crimi, H. Zhang, R. N. N. Han, L. D. Sorbo, V.M. Ranieri, and A. S. Slutsky
Ischemia and Reperfusion Increases Susceptibility to Ventilator-induced Lung Injury in Rats
Am. J. Respir. Crit. Care Med., July 15, 2006; 174(2): 178 - 186.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. G. Kiang, P. D. Bowman, X. Lu, Y. Li, X. Z. Ding, B. Zhao, Y.-T. Juang, J. L. Atkins, and G. C. Tsokos
Geldanamycin prevents hemorrhage-induced ATP loss by overexpressing inducible HSP70 and activating pyruvate dehydrogenase
Am J Physiol Gastrointest Liver Physiol, July 1, 2006; 291(1): G117 - G127.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H.-P. Yu, Y.-C. Hsieh, T. Suzuki, T. Shimizu, M. A. Choudhry, M. G. Schwacha, and I. H. Chaudry
Salutary effects of estrogen receptor-beta agonist on lung injury after trauma-hemorrhage
Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L1004 - L1009.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. J. Levine, B. Adamik, F. I. Hawari, A. Islam, Z.-X. Yu, D.-W. Liao, J. Zhang, X. Cui, and F. N. Rouhani
Proteasome inhibition induces TNFR1 shedding from human airway epithelial (NCI-H292) cells
Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L233 - L243.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
X. Meng, L. Ao, Y. Song, C. D. Raeburn, D. A. Fullerton, and A. H. Harken
Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-{alpha} receptor
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2005; 288(3): R600 - R606.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. Ramani, M. Mathier, P. Wang, G. Gibson, S. Togel, J. Dawson, A. Bauer, S. Alber, S. C. Watkins, C. F. McTiernan, et al.
Inhibition of tumor necrosis factor receptor-1-mediated pathways has beneficial effects in a murine model of postischemic remodeling
Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1369 - H1377.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. A. Barsness, J. Arcaroli, A. H. Harken, E. Abraham, A. Banerjee, L. Reznikov, and R. C. McIntyre
Hemorrhage-induced acute lung injury is TLR-4 dependent
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2004; 287(3): R592 - R599.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. G. Kiang, P. D. Bowman, B. W. Wu, N. Hampton, A. G. Kiang, B. Zhao, Y.-T. Juang, J. L. Atkins, and G. C. Tsokos
Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70
J Appl Physiol, August 1, 2004; 97(2): 564 - 569.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. D. Raeburn, C. M. Calkins, M. A. Zimmerman, Y. Song, L. Ao, A. Banerjee, A. H. Harken, and X. Meng
ICAM-1 and VCAM-1 mediate endotoxemic myocardial dysfunction independent of neutrophil accumulation
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R477 - R486.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. D. Raeburn, C. A. Dinarello, M. A. Zimmerman, C. M. Calkins, B. J. Pomerantz, R. C. McIntyre Jr., A. H. Harken, and X. Meng
Neutralization of IL-18 attenuates lipopolysaccharide-induced myocardial dysfunction
Am J Physiol Heart Circ Physiol, August 1, 2002; 283(2): H650 - H657.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
T. R. Bernik, S. G. Friedman, M. Ochani, R. DiRaimo, L. Ulloa, H. Yang, S. Sudan, C. J. Czura, S. M. Ivanova, and K. J. Tracey
Pharmacological Stimulation of the Cholinergic Antiinflammatory Pathway
J. Exp. Med., March 18, 2002; 195(6): 781 - 788.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online