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Am J Physiol Lung Cell Mol Physiol 281: L749-L761, 2001;
1040-0605/01 $5.00
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Vol. 281, Issue 4, L749-L761, October 2001

INVITED REVIEW
Regulation of apoptosis by vasoactive peptides

Gerasimos S. Filippatos1, Nupur Gangopadhyay2, Omosalewa Lalude3, Narayanan Parameswaran2, Sami I. Said4,5, William Spielman2, and Bruce D. Uhal2

1 Second Division of Cardiology, Evangelismos General Hospital, GR-11526 Athens, Greece; 2 Department of Physiology, Michigan State University, East Lansing, Michigan 48824; 3 Division of Cardiology, MetroHealth Medical Center/Case Western Reserve University, Cleveland, Ohio 44106; 4 Department of Medicine, University Medical Center, Stony Brook 11794; and 5 Veterans Affairs Medical Center, Northport, New York 11772

Although originally discovered because of their ability to affect hemodynamics, vasoactive peptides have been found to function in a variety of capacities including neurotransmission, endocrine functions, and the regulation of cell proliferation. A growing body of evidence describes the ability of vasoactive peptides to regulate cell death by apoptosis in either a positive or negative fashion depending on the peptide and the type of target cell. The available evidence to date is strongest for the peptides endothelin, angiotensin II, vasoactive intestinal peptide, atrial natriuretic peptide, and adrenomedullin. Each of these peptides is discussed, with specific regard to apoptosis, in terms of regulatory activity, target cell specificity, and potential role in pulmonary physiology.

programmed cell death; blood pressure; pulmonary pathophysiology; hypertension; lung fibrosis


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