| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of 1 Cell Biology, 2 Immunology, and 4 Medicine, Duke University Medical Center, Durham, North Carolina 27710; and 3 Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106
Surfactant protein (SP) D functions as a soluble pattern recognition molecule to mediate the clearance of pathogens by phagocytes in the innate immune response. We hypothesize that SP-D may also interact with dendritic cells, the most potent antigen presenting cell, to enhance uptake and presentation of bacterial antigens. Using mouse bone marrow-derived dendritic cells, we show that SP-D binds to immature dendritic cells in a dose-, carbohydrate-, and calcium-dependent manner, whereas SP-D binding to mature dendritic cells is reduced. SP-D also binds to Escherichia coli HB101 and enhances its association with dendritic cells. Additionally, SP-D enhances the antigen presentation of an ovalbumin fusion protein expressed in E. coli HB101 to ovalbumin-specific major histocompatibility complex class II T cell hybridomas. The enhancement of antigen presentation by SP-D is dose dependent and is not shared by other collectin-like proteins tested. These studies demonstrate that SP-D augments antigen presentation by dendritic cells and suggest that innate immune molecules such as SP-D may help initiate an adaptive immune response for the purpose of resolving an infection.
antigen presenting cell; innate immune response; adaptive immune response; phagocytosis; lung
This article has been cited by other articles:
|
|
 |
|
  A. M. Guth, W. J. Janssen, C. M. Bosio, E. C. Crouch, P. M. Henson, and S. W. Dow Lung environment determines unique phenotype of alveolar macrophages Am J Physiol Lung Cell Mol Physiol, June 1, 2009; 296(6): L936 - L946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gereke, S. Jung, J. Buer, and D. Bruder Alveolar Type II Epithelial Cells Present Antigen to CD4+ T Cells and Induce Foxp3+ Regulatory T Cells Am. J. Respir. Crit. Care Med., March 1, 2009; 179(5): 344 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Mahajan, T. Madan, N. Kamal, V. K. Singh, R. B. Sim, S. D. Telang, C. N. Ramchand, P. Waters, U. Kishore, and P. U. Sarma Recombinant surfactant protein-D selectively increases apoptosis in eosinophils of allergic asthmatics and enhances uptake of apoptotic eosinophils by macrophages Int. Immunol., August 1, 2008; 20(8): 993 - 1007. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Oberley, K. L. Goss, D. S. Hoffmann, K. A. Ault, T. L. Neff, K. H. Ramsey, and J. M. Snyder Regulation of surfactant protein D in the mouse female reproductive tract in vivo Mol. Hum. Reprod., December 1, 2007; 13(12): 863 - 868. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Pastva, J. R. Wright, and K. L. Williams Immunomodulatory Roles of Surfactant Proteins A and D: Implications in Lung Disease Proceedings of the ATS, July 1, 2007; 4(3): 252 - 257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hansen, B. Lo, K. Evans, P. Neophytou, U. Holmskov, and J. R. Wright Surfactant Protein D Augments Bacterial Association but Attenuates Major Histocompatibility Complex Class II Presentation of Bacterial Antigens Am. J. Respir. Cell Mol. Biol., January 1, 2007; 36(1): 94 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Wright The "wisdom" of lung surfactant: balancing host defense and surface tension-reducing functions Am J Physiol Lung Cell Mol Physiol, November 1, 2006; 291(5): L847 - L850. [Full Text] [PDF]
|
|
|
|
|
|
D. C. Malherbe, V. J. Erpenbeck, S. N. Abraham, E. C. Crouch, J. M. Hohlfeld, and J. R. Wright Surfactant protein D decreases pollen-induced IgE-dependent mast cell degranulation Am J Physiol Lung Cell Mol Physiol, November 1, 2005; 289(5): L856 - L866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Casey, J. Kaplan, E. N. Atochina-Vasserman, A. J. Gow, H. Kadire, Y. Tomer, J. H. Fisher, S. Hawgood, R. C. Savani, and M. F. Beers Alveolar Surfactant Protein D Content Modulates Bleomycin-induced Lung Injury Am. J. Respir. Crit. Care Med., October 1, 2005; 172(7): 869 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Schaeffer, F. X. McCormack, H. Wu, and A. A. Weiss Interactions of Pulmonary Collectins with Bordetella bronchiseptica and Bordetella pertussis Lipopolysaccharide Elucidate the Structural Basis of Their Antimicrobial Activities Infect. Immun., December 1, 2004; 72(12): 7124 - 7130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. P. Hickling, H. Clark, R. Malhotra, and R. B. Sim Collectins and their role in lung immunity J. Leukoc. Biol., January 1, 2004; 75(1): 27 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. DeSilva, I. Ofek, and E. C. Crouch Interactions of Surfactant Protein D with Fatty Acids Am. J. Respir. Cell Mol. Biol., December 1, 2003; 29(6): 757 - 770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H Clark and K Reid The potential of recombinant surfactant protein D therapy to reduce inflammation in neonatal chronic lung disease, cystic fibrosis, and emphysema Arch. Dis. Child., November 1, 2003; 88(11): 981 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takeda, N. Miyahara, Y.-H. Rha, C. Taube, E.-S. Yang, A. Joetham, T. Kodama, A. M. Balhorn, A. Dakhama, C. Duez, et al. Surfactant Protein D Regulates Airway Function and Allergic Inflammation through Modulation of Macrophage Function Am. J. Respir. Crit. Care Med., October 1, 2003; 168(7): 783 - 789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. G. Brinker, H. Garner, and J. R. Wright Surfactant protein A modulates the differentiation of murine bone marrow-derived dendritic cells Am J Physiol Lung Cell Mol Physiol, January 1, 2003; 284(1): L232 - L241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Lin and J. Floros Heterogeneous allele expression of pulmonary SP-D gene in rat large intestine and other tissues Physiol Genomics, December 3, 2002; 11(3): 235 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Borron, E. A. Mostaghel, C. Doyle, E. S. Walsh, M. G. McHeyzer-Williams, and J. R. Wright Pulmonary Surfactant Proteins A and D Directly Suppress CD3+/CD4+ Cell Function: Evidence for Two Shared Mechanisms J. Immunol., November 15, 2002; 169(10): 5844 - 5850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Shepherd Pulmonary surfactant protein D: a novel link between innate and adaptive immunity Am J Physiol Lung Cell Mol Physiol, March 1, 2002; 282(3): L516 - L517. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
