AJP - Lung Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 282: L3-L11, 2002; doi:10.1152/ajplung.00157.2001
1040-0605/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (17)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bodega, F.
Right arrow Articles by Agostoni, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bodega, F.
Right arrow Articles by Agostoni, E.
Vol. 282, Issue 1, L3-L11, January 2002

EDITORIAL FOCUS
Albumin transcytosis in mesothelium

Francesca Bodega, Luciano Zocchi, and Emilio Agostoni

Istituto di Fisiologia Umana I, Università di Milano, 20133 Milano, Italy

Apparent permeability to albumin (Palb) was measured with 125I-albumin in specimens of rabbit parietal pericardium from lumen to interstitium (L-I) and from interstitium to lumen (I-L). With albumin concentration (Calb) 0.5%, Palb (× 10-5 cm/s) L-I at 37°C was 0.172 ± 0.019 SE; it decreased to 0.092 ± 0.022 I-L at 37°C, 0.089 ± 0.021 L-I at 12°C, and 0.084 ± 0.018 I-L at 12°C. These findings provide evidence for an active transport L-I, likely transcytosis. With Calb 2.5%, 0.05%, and 0.005%, Palb L-I at 37°C was 0.188 ± 0.023, 0.156 ± 0.021, and 0.090 ± 0.021, respectively; at 12°C it was 0.089 ± 0.017, 0.083 ± 0.019, and 0.087 ± 0.026, respectively. Hence, active albumin transport ceases with Calb 0.005%; Palb values I-L at 12°C and with Calb 0.005% are similar and provide diffusional permeability. With physiological Calb (~1%), active albumin flux was ~5 × 10-4 µmol · h-1 · cm-2. Apparent permeability to FITC-dextran 70 (Pdx) was also measured. Pdx (× 10-5 cm/s) L-I at 37°C with Calb 0.5% was 0.095 ± 0.018; it decreased to 0.026 ± 0.004 I-L (37°C, Calb 0.5%), 0.038 ± 0.007 at 12°C (L-I, Calb 0.5%), 0.030 ± 0.009 with Calb 0.005% (L-I, 37°C), and 0.032 ± 0.011 with nocodazole (L-I, 37°C, Calb 0.5%). These findings provide evidence for transcytosis and confirm conclusions drawn from Palb. Vesicular liquid flow, computed from vesicular dextran flux (fluid-phase only), was ~3.5 µl · h-1 · cm-2. Transcytosis seems a relevant mechanism, removing protein and liquid from serous cavities.

albumin concentration and transcytosis; dextran; diffusional permeability; vesicular albumin flux; vesicular liquid flow


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
S. J. Lai-Fook, P. K. Houtz, and P. D. Jones
Transdiaphragmatic transport of tracer albumin from peritoneal to pleural liquid measured in rats
J Appl Physiol, December 1, 2005; 99(6): 2212 - 2221.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. Monks and M. C Neville
Albumin transcytosis across the epithelium of the lactating mouse mammary gland
J. Physiol., October 1, 2004; 560(1): 267 - 280.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. J. LAI-FOOK
Pleural Mechanics and Fluid Exchange
Physiol Rev, April 1, 2004; 84(2): 385 - 410.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
L. Zocchi
Physiology and pathophysiology of pleural fluid turnover
Eur. Respir. J., December 1, 2002; 20(6): 1545 - 1558.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. Agostoni, F. Bodega, and L. Zocchi
Albumin transcytosis from the pleural space
J Appl Physiol, November 1, 2002; 93(5): 1806 - 1812.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. M. Vogel and A. B. Malik
Albumin transcytosis in mesothelium: further evidence of a transcellular pathway in polarized cells
Am J Physiol Lung Cell Mol Physiol, January 1, 2002; 282(1): L1 - L2.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online