AJP - Lung Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 282: L501-L507, 2002. First published October 26, 2001; doi:10.1152/ajplung.00207.2001
1040-0605/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
282/3/L501    most recent
00207.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Edmonds, R. D.
Right arrow Articles by Blaisdell, C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Edmonds, R. D.
Right arrow Articles by Blaisdell, C. J.
Vol. 282, Issue 3, L501-L507, March 2002

SPECIAL TOPIC
Pre- and Postnatal Lung Development, Maturation, and Plasticity
ClC-5: ontogeny of an alternative chloride channel in respiratory epithelia

Rebecca D. Edmonds2, Ian V. Silva3, William B. Guggino2,3, Robert B. Butler1, Pamela L. Zeitlin2, and Carol J. Blaisdell1,2

1 Department of Pediatrics, University of Maryland Medical System, Baltimore 21201; and 2 Department of Pediatrics, Eudowood Division of Respiratory Sciences, 3 Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Chloride transport is critical to many functions of the lung. Molecular defects in the best-known chloride channel, cystic fibrosis transmembrane conductance regulator (CFTR), lead to impaired function of airway defensins, hydration of airway surface fluid, and mucociliary clearance leading to chronic lung disease, and premature death, but do not cause defects in lung development. We examined the expression of one member of the ClC family of volume- and voltage-regulated channels using the ribonuclease protection assay and Western blot analysis in rats. ClC-5 mRNA and protein are most strongly expressed in the fetal lung, and expression is maintained although downregulated postnatally. In addition, using immunocytochemistry, we find that ClC-5 is predominantly expressed along the luminal surface of the airway epithelium, suggesting that ClC-5 may participate in lung chloride secretion. Identifying candidate genes for critical ion transport functions is essential for understanding normal lung morphogenesis and the pathophysiology of several lung diseases. In addition, the manipulation of non-CFTR chloride channels may provide a viable approach for treating cystic fibrosis lung disease.

ion channels; developmental regulation; calcium channel family


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. J. Blaisdell, M. M. Morales, A. C. O. Andrade, P. Bamford, M. Wasicko, and P. Welling
Inhibition of CLC-2 chloride channel expression interrupts expansion of fetal lung cysts
Am J Physiol Lung Cell Mol Physiol, February 1, 2004; 286(2): L420 - L426.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
O. Devuyst and W. B. Guggino
Chloride channels in the kidney: lessons learned from knockout animals
Am J Physiol Renal Physiol, December 1, 2002; 283(6): F1176 - F1191.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
I. F. McMurtry
Editorial: Introduction: pre- and postnatal lung development, maturation, and plasticity
Am J Physiol Lung Cell Mol Physiol, March 1, 2002; 282(3): L341 - L344.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online