AJP - Lung Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 282: L573-L584, 2002; doi:10.1152/ajplung.00117.2001
1040-0605/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (20)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Haley, K. J.
Right arrow Articles by Finn, P. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Haley, K. J.
Right arrow Articles by Finn, P. W.
Vol. 282, Issue 3, L573-L584, March 2002

Alterations in lung collectins in an adaptive allergic immune response

Kathleen J. Haley1, Alex Ciota1, Johanna P. Contreras1, Mark R. Boothby2, David L. Perkins3, and Patricia W. Finn1

1 Respiratory Division and 3 Division of Molecular Immunology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; and 2 Department of Microbiology, Vanderbilt University, Nashville, Tennessee 37235

Although surfactant apoproteins are known to be mediators of innate responses, their relationship to adaptive responses has not been examined extensively. We investigated possible links between surfactant apoproteins and responses to allergens by studying alterations in surfactant apoproteins A, B, and D in a murine model of allergic pulmonary inflammation. Three murine strains (BALB/c, C57BL/6, and 129J) demonstrated increased immunostaining of surfactant apoproteins A and D in nonciliated epithelial cells of noncartilaginous airways after aerosolized challenge. In contrast, surfactant apoprotein B immunostaining was unchanged. Immunoblotting demonstrated increased surfactant A in bronchoalveolar lavage fluid after allergen sensitization and challenge. Surfactant apoprotein A and D induction required T and/or B lymphocyte responses to allergen, since the induction was absent in recombinase-activating gene-deficient mice, which lack functional lymphocytes. We conclude that increased immunoreactivity of two collectins, surfactant apoproteins A and D, occurs within the response to allergen. Our findings support a model in which surfactant apoproteins A and D are important to both innate immunity and adaptive immune responses to allergens.

lung; T lymphocytes; murine models; innate


This article has been cited by other articles:


Home page
 Am. J. Respir. Cell Mol. Bio.Home page
N. Wang, M. Campo, L. Ting, C. Fleming, C. Terhorst, and P. W. Finn
The Costimulatory Molecule SLAM Is Critical for Pulmonary Allergic Responses
Am. J. Respir. Cell Mol. Biol., August 1, 2006; 35(2): 206 - 210.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. Takeda, N. Miyahara, Y.-H. Rha, C. Taube, E.-S. Yang, A. Joetham, T. Kodama, A. M. Balhorn, A. Dakhama, C. Duez, et al.
Surfactant Protein D Regulates Airway Function and Allergic Inflammation through Modulation of Macrophage Function
Am. J. Respir. Crit. Care Med., October 1, 2003; 168(7): 783 - 789.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
I. Y. Haddad, C. Milla, S. Yang, A. Panoskaltsis-Mortari, S. Hawgood, D. L. Lacey, and B. R. Blazar
Surfactant protein A is a required mediator of keratinocyte growth factor after experimental marrow transplantation
Am J Physiol Lung Cell Mol Physiol, September 1, 2003; 285(3): L602 - L610.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online