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2-agonists to increase alveolar liquid clearance
Department of Physiology, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272-0095
We determined if prolonged
isoproterenol (Iso) infusion in rats impaired the ability of the
2-adrenergic agonist terbutaline to increase alveolar
liquid clearance (ALC). We infused rats with Iso (at rates of
4, 40, or 400 µg · kg
1 · h1) or vehicle
(0.001 N HCl) for 48 h using subcutaneously implanted miniosmotic
pumps. After this time, the rats were anesthetized, and ALC was
determined (by mass-balance after instillation of Ringer lactate
containing albumin into the lungs) under baseline conditions and after
terbutaline administration. Baseline and terbutaline-stimulated ALC in
vehicle-infused rats averaged, respectively, 19.6 ± 1.2% (SE)
and 44.7 ± 1.5%/h. The ability of terbutaline to increase
ALC was eliminated at 400 µg · kg1 · h1 Iso,
inhibited by 26% at 40 µg · kg1 · h1 Iso, and
was not affected by 4 µg · kg1 · h1 Iso.
-adrenergic receptor (AR) density of freshly isolated alveolar
epithelial type II (ATII) cells from Iso-infused rats was reduced by
the 40 and 400 µg · kg1 · h1 infusion
rates. These data demonstrate that prolonged exposure to -agonists
can impair the ability of 2-agonists to stimulate ALC
and produce ATII cell AR downregulation.
lung fluid balance; pulmonary edema; -adrenergic receptor; receptor downregulation; alveolar epithelial type II cell
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