| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Internal Medicine, Division of Pneumology, 4 Division of Pathology, Justus Liebig University, 35392 Giessen; 3 Medical Policlinic, University of Munich, 81366 Munich, Germany; 2 Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville 37232; and Department of Veterans Affairs, Nashville, Tennessee 37212
Intratracheal instillation of
the monocyte chemoattractant JE/monocyte chemoattractant protein
(MCP)-1 in mice was recently shown to cause increased alveolar
monocyte accumulation in the absence of lung inflammation, whereas
combined JE/MCP-1/lipopolysaccharide (LPS) challenge provoked acute
lung inflammation with early alveolar neutrophil and delayed alveolar
monocyte influx. We evaluated the role of resident alveolar
macrophages (rAM) in these leukocyte recruitment events and related
phenomena of lung inflammation. Depletion of rAM by pretreatment of
mice with liposomal clodronate did not affect the JE/MCP-1-driven
alveolar monocyte accumulation, despite the observation that rAM
constitutively expressed the JE/MCP-1 receptor CCR2, as analyzed by
flow cytometry and immunohistochemistry. In contrast, depletion of rAM
largely suppressed alveolar cytokine release as well as neutrophil and
monocyte recruitment profiles upon combined JE/MCP-1/LPS treatment.
Despite this strongly attenuated alveolar inflammatory response,
increased lung permeability was still observed in rAM-depleted mice
undergoing JE/MCP-1/LPS challenge. Lung leakage was abrogated by
codepletion of circulating neutrophils or administration of anti-CD18.
Collectively, rAM are not involved in JE/MCP-1-driven alveolar monocyte
recruitment in noninflamed lungs but largely contribute to the alveolar
cytokine response and enhanced early neutrophil and delayed monocyte
influx under inflammatory conditions (JE/MCP-1/LPS deposition). Loss of
lung barrier function observed under these conditions is rAM
independent but involves circulating neutrophils via
2-integrin engagement.
monocyte; neutrophil; vascular permeability; lung; inflammation; depletion
This article has been cited by other articles:
|
|
 |
|
  K. S. Farley, L. Wang, and S. Mehta Septic pulmonary microvascular endothelial cell injury: role of alveolar macrophage NADPH oxidase Am J Physiol Lung Cell Mol Physiol, March 1, 2009; 296(3): L480 - L488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Buntinx, B. Hermans, J. Goossens, D. Moechars, R. A. H. J. Gilissen, J. Doyon, S. Boeckx, E. Coesemans, G. Van Lommen, and J. P. Van Wauwe Pharmacological Profile of JNJ-27141491 [(S)-3-[3,4-Difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxyl Acid Methyl Ester], as a Noncompetitive and Orally Active Antagonist of the Human Chemokine Receptor CCR2 J. Pharmacol. Exp. Ther., October 1, 2008; 327(1): 1 - 9. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Bem, A. W. Farnand, V. Wong, A. Koski, M. E. Rosenfeld, N. van Rooijen, C. W. Frevert, T. R. Martin, and G. Matute-Bello Depletion of resident alveolar macrophages does not prevent Fas-mediated lung injury in mice Am J Physiol Lung Cell Mol Physiol, August 1, 2008; 295(2): L314 - L325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Semaeva, O. Tenstad, A. Bletsa, E.-A. B. Gjerde, and H. Wiig Isolation of rat trachea interstitial fluid and demonstration of local cytokine production in lipopolysaccharide-induced systemic inflammation J Appl Physiol, March 1, 2008; 104(3): 809 - 820. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Kelly, K. McNagny, D. L. Williams, N. van Rooijen, L. Maxwell, C. Gwozd, C. H. Mody, and P. Kubes The Lung Responds to Zymosan in a Unique Manner Independent of Toll-Like Receptors, Complement, and Dectin-1 Am. J. Respir. Cell Mol. Biol., February 1, 2008; 38(2): 227 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Mathew, G. Y. Park, H. Cao, A. C. Azim, X. Wang, R. B. Van Breemen, R. T. Sadikot, and J. W. Christman Inhibitory {kappa}B Kinase 2 Activates Airway Epithelial Cells to Stimulate Bone Marrow Macrophages Am. J. Respir. Cell Mol. Biol., May 1, 2007; 36(5): 562 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. A. Maus, M. Backi, C. Winter, M. Srivastava, M. K. Schwarz, T. Ruckle, J. C. Paton, D. Briles, M. Mack, T. Welte, et al. Importance of Phosphoinositide 3-Kinase {gamma} in the Host Defense against Pneumococcal Infection Am. J. Respir. Crit. Care Med., May 1, 2007; 175(9): 958 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Farley, L. F. Wang, H. M. Razavi, C. Law, M. Rohan, D. G. McCormack, and S. Mehta Effects of macrophage inducible nitric oxide synthase in murine septic lung injury Am J Physiol Lung Cell Mol Physiol, June 1, 2006; 290(6): L1164 - L1172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Meyer, L. D. Dwyer-Nield, G. Hurteau, R. L. Keith, Y. Ouyang, B. M. Freed, L. R. Kisley, M. W. Geraci, J. V. Bonventre, R. A. Nemenoff, et al. Attenuation of the pulmonary inflammatory response following butylated hydroxytoluene treatment of cytosolic phospholipase A2 null mice Am J Physiol Lung Cell Mol Physiol, June 1, 2006; 290(6): L1260 - L1266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Vlahos, S. Bozinovski, J. E. Jones, J. Powell, J. Gras, A. Lilja, M. J. Hansen, R. C. Gualano, L. Irving, and G. P. Anderson Differential protease, innate immunity, and NF-{kappa}B induction profiles during lung inflammation induced by subchronic cigarette smoke exposure in mice Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L931 - L945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Knapp, C. W. Wieland, S. Florquin, R. Pantophlet, L. Dijkshoorn, N. Tshimbalanga, S. Akira, and T. van der Poll Differential Roles of CD14 and Toll-like Receptors 4and 2 in Murine Acinetobacter Pneumonia Am. J. Respir. Crit. Care Med., January 1, 2006; 173(1): 122 - 129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Everhart, W. Han, K. S. Parman, V. V. Polosukhin, H. Zeng, R. T. Sadikot, B. Li, F. E. Yull, J. W. Christman, and T. S. Blackwell Intratracheal administration of liposomal clodronate accelerates alveolar macrophage reconstitution following fetal liver transplantation J. Leukoc. Biol., February 1, 2005; 77(2): 173 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Jennings, D. J. Linderman, B. Hu, J. Sonstein, and J. L. Curtis Monocytes Recruited to the Lungs of Mice during Immune Inflammation Ingest Apoptotic Cells Poorly Am. J. Respir. Cell Mol. Biol., February 1, 2005; 32(2): 108 - 117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Spight, B. Zhao, M. Haas, S. Wert, A. Denenberg, and T. P. Shanley Immunoregulatory effects of regulated, lung-targeted expression of IL-10 in vivo Am J Physiol Lung Cell Mol Physiol, February 1, 2005; 288(2): L251 - L265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. A. Maus, S. Wellmann, C. Hampl, W. A. Kuziel, M. Srivastava, M. Mack, M. B. Everhart, T. S. Blackwell, J. W. Christman, D. Schlondorff, et al. CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels Am J Physiol Lung Cell Mol Physiol, February 1, 2005; 288(2): L350 - L358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Puneet, S. Moochhala, and M. Bhatia Chemokines in acute respiratory distress syndrome Am J Physiol Lung Cell Mol Physiol, January 1, 2005; 288(1): L3 - L15. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Ye Leukocyte inflammatory mediators and lung pathophysiology: an update Am J Physiol Lung Cell Mol Physiol, March 1, 2004; 286(3): L461 - L462. [Full Text] [PDF]
|
|
|
|
|
|
M. A. Vozzelli, S. N. Mason, M. H. Whorton, and R. L. Auten Jr. Antimacrophage chemokine treatment prevents neutrophil and macrophage influx in hyperoxia-exposed newborn rat lung Am J Physiol Lung Cell Mol Physiol, March 1, 2004; 286(3): L488 - L493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. A. Maus, K. Waelsch, W. A. Kuziel, T. Delbeck, M. Mack, T. S. Blackwell, J. W. Christman, D. Schlondorff, W. Seeger, and J. Lohmeyer Monocytes Are Potent Facilitators of Alveolar Neutrophil Emigration During Lung Inflammation: Role of the CCL2-CCR2 Axis J. Immunol., March 15, 2003; 170(6): 3273 - 3278. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
