| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of 2 Pediatrics and 1 Obstetrics and Gynecology, Harbor-University of California Los Angeles Research and Education Institute, Torrance, California 90502
Intrauterine lung development, culminating in physiological pulmonary surfactant production by epithelial type II (TII) cells, is driven by fluid distension through unknown mechanisms. Differentiation of alveolar epithelial and mesenchymal cells is mediated by soluble factors like parathyroid hormone-related protein (PTHrP), a stretch-sensitive TII cell product. PTHrP stimulates pulmonary surfactant production by a paracrine feedback loop mediated by leptin, a soluble product of the mature lipofibroblast (LF). When LFs and TIIs are stretched in coculture, there is a fivefold increase in surfactant phospholipid synthesis that can be "neutralized" by inhibitors of PTHrP or leptin, implicating a paracrine feedback loop in this mechanism. Stretching LFs stimulates PTHrP binding (2.5-fold) and downstream stimulation of triglyceride uptake quantitatively (15-25%) due to upregulation of adipose differentiation-related protein expression. Stretching TII cells increases leptin stimulation of their surfactant phospholipid synthesis threefold, suggesting that retrograde signaling by leptin to TII cells is also stretch sensitive. We conclude that the effect of stretch on alveolar LF and TII differentiation is coordinated by PTHrP, leptin, and their receptors.
lipofibroblast; parathyroid hormone-related protein; leptin; adipose differentiation-related protein
This article has been cited by other articles:
|
|
 |
|
  V. K. Rehan, S. K. Dargan-Batra, Y. Wang, L. Cerny, R. Sakurai, J. Santos, R. Beloosesky, D. Gayle, and J. S. Torday A paradoxical temporal response of the PTHrP/PPAR{gamma} signaling pathway to lipopolysaccharide in an in vitro model of the developing rat lung Am J Physiol Lung Cell Mol Physiol, July 1, 2007; 293(1): L182 - L190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Torday and V. K. Rehan The evolutionary continuum from lung development to homeostasis and repair Am J Physiol Lung Cell Mol Physiol, March 1, 2007; 292(3): L608 - L611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. K. Rehan, Y. Wang, S. Sugano, J. Santos, S. Patel, R. Sakurai, L. W. Boros, W.-P. Lee, and J. S. Torday In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L323 - L333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Henson and V. D. Castracane Leptin in Pregnancy: An Update Biol Reprod, February 1, 2006; 74(2): 218 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Johnston, T. A. Theman, and S. A. Shore Augmented responses to ozone in obese carboxypeptidase E-deficient mice Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R126 - R133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. K. Rehan, Y. Wang, S. Sugano, S. Romero, X. Chen, J. Santos, A. Khazanchi, and J. S. Torday Mechanism of nicotine-induced pulmonary fibroblast transdifferentiation Am J Physiol Lung Cell Mol Physiol, October 1, 2005; 289(4): L667 - L676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Hammond, K. A. Bennett, M. J. Walton, and A. J. Hall Molecular cloning and expression of leptin in gray and harbor seal blubber, bone marrow, and lung and its potential role in marine mammal respiratory physiology Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R545 - R553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. E. Vlahakis and R. D. Hubmayr Cellular Stress Failure in Ventilator-injured Lungs Am. J. Respir. Crit. Care Med., June 15, 2005; 171(12): 1328 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Torday and V. K. Rehan Deconvoluting Lung Evolution Using Functional/Comparative Genomics Am. J. Respir. Cell Mol. Biol., July 1, 2004; 31(1): 8 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. M. Rivera-Sanchez, R. A. Johnston, I. N. Schwartzman, J. Valone, E. S. Silverman, J. J. Fredberg, and S. A. Shore Differential effects of ozone on airway and tissue mechanics in obese mice J Appl Physiol, June 1, 2004; 96(6): 2200 - 2206. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M C Henson, K F Swan, D E Edwards, G W Hoyle, J Purcell, and V D Castracane Leptin receptor expression in fetal lung increases in late gestation in the baboon: a model for human pregnancy Reproduction, January 1, 2004; 127(1): 87 - 94. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
