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Am J Physiol Lung Cell Mol Physiol 283: L156-L162, 2002. First published February 15, 2002; doi:10.1152/ajplung.00155.2001
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Vol. 283, Issue 1, L156-L162, July 2002

Role of macrophage migration inhibitory factor in bleomycin-induced lung injury and fibrosis in mice

Yoshinori Tanino1, Hironi Makita1, Kenji Miyamoto1, Tomoko Betsuyaku1, Yoshinori Ohtsuka2, Jun Nishihira3, and Masaharu Nishimura1

1 First Department of Medicine and 3 Central Research Institute, Hokkaido University School of Medicine, Sapporo 060-8638; and 2 Department of Pulmonary Medicine, Fukushima Medical University, Fukushima 960-1295, Japan

Macrophage migration inhibitory factor (MIF) is a unique cytokine that reportedly overrides the anti-inflammatory effect of endogenous glucocorticoids. MIF has been demonstrated to be involved in a variety of inflammatory diseases. In this study, we examined the role of MIF in bleomycin (BLM)-induced lung injury and fibrosis. The levels of MIF in lung tissues and bronchoalveolar lavage fluids were significantly increased in the period 5-10 days after intratracheal administration of BLM. Treatment with the anti-MIF antibody significantly reduced the mortality at 14 days and the histopathological lung injury score at 10 days. These effects were accompanied with significant suppression of the accumulation of inflammatory cells in the alveolar space and tumor necrosis factor-alpha in the lungs at 7 days. However, the anti-MIF antibody did not affect either the content of lung hydroxyproline or the histopathological lung fibrosis score at 21 days after BLM. These data provide further evidence for the crucial role of MIF in acute lung inflammation but do not support the involvement of MIF in lung fibrosis induced by BLM in mice.

macrophage migration inhibitory factor; bleomycin; lung fibrosis; tumor necrosis factor-alpha


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