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Am J Physiol Lung Cell Mol Physiol 283: L275-L287, 2002. First published February 8, 2002; doi:10.1152/ajplung.00423.2001
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Vol. 283, Issue 2, L275-L287, August 2002

Dexamethasone-induced changes in lung function are not prevented by concomitant treatment with retinoic acid

Ganesh Srinivasan1, Eugene N. Bruce2, Pamela K. Houtz2, and Margaret C. Bruce1

1 Department of Pediatrics and 2 Center for Biomedical Engineering, University of Kentucky Medical School, Lexington, Kentucky 40536

Alveolarization is impaired in rats treated with dexamethasone (Dex) on postnatal days 4-13, but concomitant treatment with all-trans retinoic acid (RA) increases alveolar number. To determine whether morphological changes induced by Dex and/or RA predict changes in lung function at 1 mo, we assessed resting breathing parameters, dynamic compliance, ventilation required to maintain O2 saturation at >= 90%, and pressure-volume curves of air-filled lungs. During resting breathing, mean tidal volume per gram was greater in Dex + RA-treated rats than in controls (P < 0.05). Dynamic compliance was also greater in Dex- and Dex + RA-treated rats than in controls or RA-treated rats (P < 0.02). In Dex- and Dex + RA-treated rats, we observed increased hysteresis ratios (P <=  0.006), air trapping (P < 0.05), and lung volumes at 5 and 13.5 cmH2O pressure (P < 0.001) and decreased elastic recoil (P < 0.007). The effect of Dex on elastic recoil was greater in female than in male rats (P = 0.006). Despite impaired septation, O2 saturation was not compromised in Dex- or Dex + RA-treated rats. Thus lung function changes induced by Dex treatment during alveolarization were not prevented by concomitant treatment with RA.

gender effects of dexamethasone; dynamic compliance; oxygen saturation; hysteresis; lung recoil


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