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1 Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, California 94143-0130; 2 Lung Biology Laboratory, Columbia University, New York, New York 10019; 3 Biomedical Engineering, Tulane University, New Orleans, Louisiana 70118; 4 Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee 37232; 5 Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224; 6 Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114; 7 Department of Pediatrics, University of South Alabama, Mobile, Alabama 36604; and 8 Pulmonary and Critical Care Division, Mayo Clinic, Rochester, Minnesota 55905
A lung-protective ventilator strategy significantly reduces mortality in patients with acute lung injury. Substantial progress has been made in understanding how mechanical stress can injure the lung, both in terms of alterations in barrier properties of the pulmonary endothelium and epithelium as well as in stimulating proinflammatory responses of macrophages and neutrophils.
acute lung injury; macrophages; neutrophils
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