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Department of Physiology, University of South Alabama, Mobile, Alabama 36688
The response of segmental filtration
coefficients (Kf) to high peak inflation
pressure (PIP) injury was determined in isolated perfused rat lungs.
Total (Kf,t), arterial
(Kf,a), and venous (Kf,v)
filtration coefficients were measured under baseline conditions and
after ventilation with 40-45 cmH2O PIP.
Kf,a and Kf,v were measured under zone I conditions by increasing airway
pressure to 25-27 cmH2O. The microvascular segment
Kf (Kf,mv) was then calculated by: Kf,mv = Kf,t 
Kf,a Kf,v. The baseline Kf,t
was 0.090 ± 0.022 ml · min
1 · cmH2O1 · 100 g1 and segmentally distributed 18% arterial, 41%
venous, and 41% microvascular. After high PIP injury,
Kf,t increased by 680%, whereas
Kf,a, Kf,v, and
Kf,mv increased by 398, 589, and 975%, respectively. Pretreatment with 50 µM gadolinium chloride prevented the high PIP-induced increase in Kf in all
vascular segments. These data imply a lower hydraulic conductance for
microvascular endothelium due to its large surface area and a
gadolinium-sensitive high-PIP injury, produced in both alveolar and
extra-alveolar vessel segments.
barotrauma; mechanical ventilation; capillary permeability; gadolinium; filtration coefficient
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