AJP - Lung AJP: Lung Cellular and Molecular Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 284: L360-L367, 2003. First published October 11, 2002; doi:10.1152/ajplung.00158.2002
1040-0605/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/2/L360    most recent
00158.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (25)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Madjdpour, C.
Right arrow Articles by Beck-Schimmer, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Madjdpour, C.
Right arrow Articles by Beck-Schimmer, B.
Vol. 284, Issue 2, L360-L367, February 2003

Decreased alveolar oxygen induces lung inflammation

C. Madjdpour1,2, U. R. Jewell1, S. Kneller1,2, U. Ziegler3, R. Schwendener4, C. Booy1, L. Kläusli3, T. Pasch2, R. C. Schimmer5, and B. Beck-Schimmer1,2

Institutes of 1 Physiology, 2 Anesthesiology, and 3 Anatomy, and 5 Department of Surgery, University of Zurich, 8057 Zurich; and 4 Paul Scherrer Institute, 5232 Villigen, Switzerland

Molecular mechanisms of the inflammatory reaction in hypoxia-induced lung injury are not well defined. Therefore, effects of alveolar hypoxia were studied in rat lungs, exposing rats to 10% oxygen over periods of 1, 2, 4, 6, and 8 h. An increase in the number of macrophages in bronchoalveolar lavage fluid of hypoxic animals was shown between 1 and 8 h. Extravasation of albumin was enhanced after 1 h and remained increased throughout the study period. NF-kappa B-binding activity as well as mRNA for TNF-alpha , macrophage inflammatory protein (MIP)-1beta , and monocyte chemoattractant protein (MCP)-1 were increased within the first 2 h of exposure to hypoxia. Hypoxia-inducible factor (HIF)-1alpha and intercellular adhesion molecule (ICAM)-1 mRNA were upregulated between 1 and 6 h. Elimination of alveolar macrophages by intratracheal application of liposome-encapsulated clodronate led to a decreased expression of NF-kappa B binding activity, HIF-1alpha , TNF-alpha , ICAM-1, and MIP-1beta . In summary, alveolar hypoxia induced macrophage recruitment, an increase in albumin leakage, and enhanced expression of inflammatory mediators, which were mainly macrophage dependent. Alveolar macrophages appear to have a prominent role in the inflammatory response in hypoxia-induced lung injury and the related upregulation of inflammatory mediators.

hypoxia; inflammatory mediators; lung injury


This article has been cited by other articles:


Home page
 BloodHome page
R. Kiefmann, J. M. Rifkind, E. Nagababu, and J. Bhattacharya
Red blood cells induce hypoxic lung inflammation
Blood, May 15, 2008; 111(10): 5205 - 5214.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. M. Otto, K. Markstaller, O. Kajikawa, J. Karmrodt, R. S. Syring, B. Pfeiffer, V. P. Good, C. W. Frevert, and J. E. Baumgardner
Spatial and temporal heterogeneity of ventilator-associated lung injury after surfactant depletion
J Appl Physiol, May 1, 2008; 104(5): 1485 - 1494.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Tzouvelekis, V. Harokopos, T. Paparountas, N. Oikonomou, A. Chatziioannou, G. Vilaras, E. Tsiambas, A. Karameris, D. Bouros, and V. Aidinis
Comparative Expression Profiling in Pulmonary Fibrosis Suggests a Role of Hypoxia-inducible Factor-1{alpha} in Disease Pathogenesis
Am. J. Respir. Crit. Care Med., December 1, 2007; 176(11): 1108 - 1119.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. C. Gonzalez, J. Allen, V. G. Blanco, E. J. Schmidt, N. van Rooijen, and J. G. Wood
Alveolar macrophages are necessary for the systemic inflammation of acute alveolar hypoxia
J Appl Physiol, October 1, 2007; 103(4): 1386 - 1394.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
L. M. Gazoni, C. G. Tribble, M. Q. Zhao, E. B. Unger, R. A. Farrar, P. I. Ellman, L. G. Fernandez, V. E. Laubach, and I. L. Kron
Pulmonary Macrophage Inhibition and Inhaled Nitric Oxide Attenuate Lung Ischemia-Reperfusion Injury
Ann. Thorac. Surg., July 1, 2007; 84(1): 247 - 253.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. Nowak, S. Weih, R. Metzger, R. F. Albrecht II, S. Post, P. Hohenberger, M.-M. Gebhard, and S. M. Danilov
Immunotargeting of catalase to lung endothelium via anti-angiotensin-converting enzyme antibodies attenuates ischemia-reperfusion injury of the lung in vivo
Am J Physiol Lung Cell Mol Physiol, July 1, 2007; 293(1): L162 - L169.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
D. Suter, D. R. Spahn, S. Blumenthal, L. Reyes, C. Booy, B. R. Z'graggen, and B. Beck-Schimmer
The Immunomodulatory Effect of Sevoflurane in Endotoxin-Injured Alveolar Epithelial Cells
Anesth. Analg., March 1, 2007; 104(3): 638 - 645.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Hinton, A. Gutsol, and S. Dakshinamurti
Thromboxane hypersensitivity in hypoxic pulmonary artery myocytes: altered TP receptor localization and kinetics
Am J Physiol Lung Cell Mol Physiol, March 1, 2007; 292(3): L654 - L663.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Zhao, L. G. Fernandez, A. Doctor, A. K. Sharma, A. Zarbock, C. G. Tribble, I. L. Kron, and V. E. Laubach
Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury
Am J Physiol Lung Cell Mol Physiol, November 1, 2006; 291(5): L1018 - L1026.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
K. R. Stenmark, K. A. Fagan, and M. G. Frid
Hypoxia-Induced Pulmonary Vascular Remodeling: Cellular and Molecular Mechanisms
Circ. Res., September 29, 2006; 99(7): 675 - 691.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. D. Zee, S. Schomberg, and T. C. Carpenter
Hypoxia upregulates lung microvascular neurokinin-1 receptor expression
Am J Physiol Lung Cell Mol Physiol, July 1, 2006; 291(1): L102 - L110.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Dehler, E. Zessin, P. Bartsch, and H. Mairbaurl
Hypoxia causes permeability oedema in the constant-pressure perfused rat lung.
Eur. Respir. J., March 1, 2006; 27(3): 600 - 606.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. M. Mercken, G. J. Hageman, A. M. W. J. Schols, M. A. Akkermans, A. Bast, and E. F. M. Wouters
Rehabilitation Decreases Exercise-induced Oxidative Stress in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., October 15, 2005; 172(8): 994 - 1001.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. M. Stapleton, M. Jaradat, D. Dixon, H. S. Kang, S.-C. Kim, G. Liao, M. A. Carey, J. Cristiano, M. P. Moorman, and A. M. Jetten
Enhanced susceptibility of staggerer (ROR{alpha}sg/sg) mice to lipopolysaccharide-induced lung inflammation
Am J Physiol Lung Cell Mol Physiol, July 1, 2005; 289(1): L144 - L152.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
E. F. M. Wouters
Local and Systemic Inflammation in Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, April 1, 2005; 2(1): 26 - 33.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. R. Stenmark, N. J. Davie, J. T. Reeves, and M. G. Frid
Hypoxia, leukocytes, and the pulmonary circulation
J Appl Physiol, February 1, 2005; 98(2): 715 - 721.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
B. Beck-Schimmer, R.C. Schimmer, and T. Pasch
The Airway Compartment: Chambers of Secrets
Physiology, June 1, 2004; 19(3): 129 - 132.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Duggan, C. L. McCaul, P. J. McNamara, D. Engelberts, C. Ackerley, and B. P. Kavanagh
Atelectasis Causes Vascular Leak and Lethal Right Ventricular Failure in Uninjured Rat Lungs
Am. J. Respir. Crit. Care Med., June 15, 2003; 167(12): 1633 - 1640.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online